Scalp melanoma after antihair loss mesotherapy

Arenberger, Petr; Gkalpakiotis, Spyridon; Dahmen, Robert Artur; Sticová, Eva; Fialová, Alena

doi:10.1111/jdv.14690

Cited by 7 publications

(15 citation statements)

References 9 publications

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“…Finally, a potentially life‐threatening complication was recently reported by Arenbergerova et al, who described the development of a nodular melanoma on a congenital naevus on the scalp of a 49‐year‐old patient, after treatment of a mild telogen effluvium, with a mesotherapeutic cocktail containing IGF‐1, bFGF, VEGF, copper tripeptide‐1, as well as adipose‐derived stem cell extract . Although the authors do not exclude the possibility of a coincidental event, a potential acceleration of the melanoma development due to the effect of all the injected growth factors must be definitely taken into consideration . More studies on the safety profile of such substances on the aspect of oncogenesis should be conducted in order to draw clear conclusions .…”

Section: Resultsmentioning

confidence: 98%

“…Although the authors do not exclude the possibility of a coincidental event, a potential acceleration of the melanoma development due to the effect of all the injected growth factors must be definitely taken into consideration . More studies on the safety profile of such substances on the aspect of oncogenesis should be conducted in order to draw clear conclusions . Furthermore, it is advisable to examine carefully the area to be treated, with an emphasis on melanocytic nevi …”

Section: Resultsmentioning

confidence: 99%

“…5 More studies on the safety profile of such substances on the aspect of oncogenesis should be conducted in order to draw clear conclusions. 5 Furthermore, it is advisable to examine carefully the area to be treated, with an emphasis on melanocytic nevi. 5…”

Section: Granulomatous Foreign Body Reactions Have Been Reported Tomentioning

confidence: 99%

“…Mesotherapy has gained massive popularity over the last years, due to the fact that it offers an inexpensive direct drug delivery in the area of interest and it requires minimal training for the physicians . The development of various mesotherapeutic protocols for numerous indications makes the cumulative safety evaluation difficult and no larger cohort studies for risk assessment on mesotherapy have been conducted up to this point . This report aims to present all the mesotherapy‐associated complications reported in the literature so far and to provide an insight into as far as their management is concerned.…”

Section: Introductionmentioning

confidence: 99%

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Mesotherapy: Safety profile and management of complications

Plachouri

Georgiou

2019

J of Cosmetic Dermatology

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Background Mesotherapy is a procedure that involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes. Objectives The aim of this paper is to summarize all the mesotherapy‐related complications published so far, and to provide an insight into their management. Patient/Methods Articles derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines. Results In this literature, there is a number of case series and isolated case reports describing various side effects of different severities. The therapeutic management of these complications is—in most cases—individualized. Conclusions Larger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardized therapy parameters, so as to minimize the risk of potential adverse reactions.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Granulomatous Foreign Body Reactions Have Been Reported Tomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesotherapy: Safety profile and management of complications

Plachouri

Georgiou

2019

J of Cosmetic Dermatology

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“…In this last case, the authors did not define whether the relationship was causal or casual. 5,14 In a previous case report of frontal edema, Güngör et al implied the topical minoxidil application after mesotherapy caused the adverse event, since mesotherapy with biotin, when done alone, was not associated with any side effects. 15 In our patients, the edema mostly arose in the first two sessions and lasted between 1 and 4 days, with a favorable outcome after a local cold compress.…”

mentioning

confidence: 99%

Frontal edema due to mesotherapy for androgenetic alopecia: A case series

Melo

Saceda‐Corralo

Tosti

et al. 2021

Dermatologic Therapy

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Androgenetic alopecia (AGA) is the most common form of non-cicatricial alopecia in both genders. Currently approved drugs for the treatment of AGA include topical minoxidil in women and topical minoxidil and oral finasteride in men. Other routes of administration of approved drugs have been proposed to enhance therapeutic results for AGA, including intradermal injections, known as mesotherapy. Mesotherapy-or intradermotherapy-is a non-surgical procedure, consisting of multiple intradermal injections of pharmacological substances diluted in small doses. Although minimally invasive, mesotherapy may be related to mild side effects like burning, erythema and headaches, as a few reports indicate. Among the most serious adverse events, subcutaneous necrosis, scalp abscesses, and angioedema have been described. This multicenter retrospective, descriptive study aims to report 14 cases of frontal edema resulting from mesotherapy for AGA treatment. In our patients, the edema mostly arose in the first two sessions and lasted between 1 and 4 days, with a favorable outcome after a local cold compress. In all our cases of edema, lidocaine was the anesthetic used. Minoxidil and dutasteride might also play a role as causative agents. To the best of our knowledge, this is the largest case series focused on frontal edema after mesotherapy for AGA and gives clinicians helpful information for when performing this technique. Dermatologists should already consider and be conscious of this possible mesotherapy side effect, as it can be remarkably disruptive to affected patients.

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