Mesotherapy: Safety profile and management of complications

Abstract

Background Mesotherapy is a procedure that involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes. Objectives The aim of this paper is to summarize all the mesotherapy‐related complications published so far, and to provide an insight into their management. Patient/Methods Articles derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines. Results In this literature, there is a number of case series and isolated case reports describing various side effects of different severities. The therapeutic management of these complications is—in most cases—individualized. Conclusions Larger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardized therapy parameters, so as to minimize the risk of potential adverse reactions.

Two Cases of Paradoxical Nonscarring Alopecia after Mesotherapy with Dutasteride

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Post-treatment physiological effects, adverse effects and complications after the selected aesthetic treatments. Review of the literature

“…A dangerous reaction to an allergen that may occur during the procedure is anaphylactic shock, which is results in an ambulance call, doctor's intervention and first aid by a cosmetologist. Complications after needle mesotherapy also include discoloration resulting from unauthorized sun exposure [25][26][27].…”

Mesococktails and mesoproducts in aesthetic dermatology

“…Microbotox may be used for the following indications, although it is particularly effective in treating neck and lower face rhytids 07,20,21 …”

“…Lately, mesobotox has also been used for relaxation of the muscle fibers in the scalp, thereby resulting in dilation of the blood vessels in the scalp region promoting better nutrient supply to the hair follicles.7 Microbotox may be used for the following indications, although it is particularly effective in treating neck and lower face rhytids. 07,20,21 (f) Dynamic forehead lines (g) Glabellar lines (h) Lateral canthal lines (i) Lower face (j) Neck lines (Platysmal bands) ways of preparing microbotox solutions and this may depend on injector preference and the area being treated. 1.…”