Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature‐induced periodontitis

Camacho-Alonso, Fabio; Davia-Peña, R. S.; Vilaplana-Vivo, Carlos; Tudela-Mulero, M R; Merino, Joaquin; Beneyto, Yolanda Martínez

doi:10.1111/jre.12515

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Camacho‐Alfonso et al . evaluated their potential synergistic effect in a murine model (82). The combined approach therapy of PDT and alendronate (0.25 mg kg −1 ) demonstrated a significant protective effect on reducing bone loss.…”

Section: Osseointegration and Bone Repairmentioning

confidence: 99%

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Choe

Balhaddad

Fisher

et al. 2021

Photochem & Photobiology

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Dental implants are the most common rehabilitation and restorative treatment used to replace missing teeth. Biofilms adhere to implant surfaces to trigger implant‐associated infection and inflammatory response. Clinically, the biofilm induces a local host response with the infiltration of phagocytic immune cells. The pro‐inflammatory surroundings set off osteoclastogenesis, which leads to the septic loosening of the implant. The standard of dental care for implant‐associated infection relies on a combination of surgery and antimicrobial therapy. Antimicrobial photodynamic therapy is a noninvasive and photochemistry‐based approach capable of reducing bacterial load and modulating inflammatory responses. In this review, we explore the photobiomodulation and disinfection outcomes promoted by photodynamic therapy for implant infections, highlighting the quality of evidence on the most up‐to‐date studies, and discuss the major challenges on the advance of these therapeutic strategies.

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Section: Osseointegration and Bone Repairmentioning

confidence: 99%

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Choe

Balhaddad

Fisher

et al. 2021

Photochem & Photobiology

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“…As an explanation of the results of the present study, it should be highlighted that the dysfunctional damage at the endothelium level found in patients with periodontitis and with CVD can be determined by a specific inflammatory and immune pathway in which MPO modulates a response towards pathogenic bacteria of the oral biofilm which are exacerbated during the active phases of periodontal damage. It has also been shown that MPO, during periodontal disease, mediates the immune response at the endothelial level through specific heat shock proteins which has been shown to be useful for stimulating the production of cross-reactive T cells [47][48][49][50][51][52]. In this regard, this process which sees MPO as a key modulator [53][54][55][56][57][58], has also been shown to influence the host defense mechanism that determines a subsequent activation of endothelial cell production [55,[58][59][60][61][62][63] which leads to an increased risk of future tissue damage effects due to periodontal pathogens bacteria in several oral diseases [43,[64][65][66][67][68].…”

Section: Discussionmentioning

confidence: 99%

Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study

et al. 2020

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In this trial, we evaluated the influence on plasma and salivary myeloperoxidase (MPO) levels of periodontal health, coronary heart disease (CHD), periodontitis, or both periodontitis and CHD. Clinical and periodontal parameters were collected from periodontitis patients (n = 31), CHD patients (n = 31), patients with both periodontitis and CHD (n = 31), and from healthy patients (n = 31) together with saliva and plasma samples. The median concentrations of salivary and plasma MPO were statistically higher in the CHD patients [plasma: 26.2 (18.2–34.4) ng/mg; saliva 83.2 (77.4–101.5) ng/mL, p < 0.01] and in the periodontitis plus CHD patients [plasma: 27.8 (22.5–35.7) ng/mg; saliva 85.6 (76.5–106.7) ng/mL, p < 0.001] with respect to periodontitis and control patients. Through a univariate regression analysis, c-reactive protein (CRP) and CHD (both p < 0.001) and periodontitis (p = 0.024) were statistically correlated with MPO in plasma. The multivariate regression analysis demonstrated that only CRP was statistically the predictor of MPO in plasma (p < 0.001). The multivariate regression analysis in saliva demonstrated that, regarding MPO levels the only predictors were CRP (p < 0.001) and total cholesterol (p = 0.035). The present study evidenced that subjects with CHD and periodontitis plus CHD had higher plasma and salivary levels of MPO compared to subjects with periodontitis and healthy controls.

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“…To the best of our knowledge, this is the first study to evaluate combination of topical use of ALN and aPDT. Camacho‐Alonso et al 48 also evaluated the synergistic effect of aPDT and ALN on alveolar bone loss in rats with ligature‐induced periodontitis, but with systemic use of alendronate. They also evaluated whether different ALN dosages had different results and concluded that a combined approach of aPDT plus ALN 0.25 mg/kg demonstrated a protective effect on alveolar bone loss.…”

Section: Discussionmentioning

confidence: 99%

Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats

Santinoni

Silveira

Caldeira

et al. 2020

J of Periodontal Research

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Objective: The purpose of this study was to evaluate influence of topical sodium alendronate (ALN), photodynamic therapy (aPDT), or a combination thereof as adjuvant to scaling and root planing (SRP) in the treatment of experimental periodontitis in rats. Background: Therapeutic protocols to control periodontitis progression that aim to equalize bacterial action and load with tissue immune response are well addressed in current scientific research. Methods: Experimental periodontitis was induced in 96 rats with a ligature around the mandibular left first molar. After 7 days, ligature was removed and animals were treated according to the following experimental groups (n = 8): control-SRP plus saline solution; ALN-SRP plus ALN; aPDT-SRP plus methylene blue irrigation, followed by low-level laser therapy (LLLT); and ALN/aPDT-SRP plus ALN and methylene blue irrigation followed by LLLT. The animals were euthanized at 7, 15, and 30 days after treatments. Collagen maturation (picrosirius red staining) and immunohistochemical analyses (TRAP, RANKL and osteoprotegerin [OPG]) were performed. Data were submitted to statistical analysis (P < .05). Results: At 7 days, group ALN presented a significantly higher number of TRAPpositive cells and percentage of immature collagen fibers than group ALN/aPDT, while group ALN/aPDT presented a significantly higher percentage of mature collagen fibers than group ALN. At 30 days, group ALN presented significantly lower percentage of immature collagen fibers and higher percentage of mature collagen fibers than control. Conclusion: It can be concluded that topical use of ALN coadjutant to SRP, alone or combined with aPDT, enhanced collagen maturation and reduced osteoclastogenesis during the healing of experimental periodontitis. K E Y W O R D S collagen, osteoclast, periodontal therapy, photochemotherapy | 851 SANTINONI eT Al. How to cite this article: Santinoni CS, Silveira FM, Caldeira ML, et al. Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats.

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Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature‐induced periodontitis

Abstract: Combined approach therapy of PDT + ALN 0.25 mg/kg demonstrated a protective effect on alveolar bone loss.

Cited by 14 publications

References 42 publications

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study

Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats

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