Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study

Polizzi, Alessandro; Torrisi, Salvatore; Santonocito, Simona; Stefano, Mattia Di; Indelicato, Francesco; Giudice, Antonino Lo

doi:10.3390/app10031037

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…Therefore, saliva thus appears as an excellent candidate matrix for evaluating the general redox status (balance between oxidants and antioxidants) of an individual. It is important to note, however, that results may be affected by dental hygiene or local oral infection [94]. In our study, the majority of individual PAOT-Saliva Scores were low as compared to the reference interval (Figure S3).…”

Section: (C) Paot ® -Scores and Correlations With Os Plasma Biomarkersmentioning

confidence: 58%

A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity

Pincemaïl

Rousseau

Kaux³

et al. 2023

Biomedicines

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Background: Oxidative stress (OS) could cause various COVID-19 complications. Recently, we have developed the Pouvoir AntiOxydant Total (PAOT®) technology for reflecting the total antioxidant capacity (TAC) of biological samples. We aimed to investigate systemic oxidative stress status (OSS) and to evaluate the utility of PAOT® for assessing TAC during the recovery phase in critical COVID-19 patients in a rehabilitation facility. Materials and Methods: In a total of 12 critical COVID-19 patients in rehabilitation, 19 plasma OSS biomarkers were measured: antioxidants, TAC, trace elements, oxidative damage to lipids, and inflammatory biomarkers. TAC level was measured in plasma, saliva, skin, and urine, using PAOT and expressed as PAOT-Plasma, -Saliva, -Skin, and -Urine scores, respectively. Plasma OSS biomarker levels were compared with levels from previous studies on hospitalized COVID-19 patients and with the reference population. Correlations between four PAOT scores and plasma OSS biomarker levels were analyzed. Results: During the recovery phase, plasma levels in antioxidants (γ-tocopherol, β-carotene, total glutathione, vitamin C and thiol proteins) were significantly lower than reference intervals, whereas total hydroperoxides and myeloperoxidase (a marker of inflammation) were significantly higher. Copper negatively correlated with total hydroperoxides (r = 0.95, p = 0.001). A similar, deeply modified OSS was already observed in COVID-19 patients hospitalized in an intensive care unit. TAC evaluated in saliva, urine, and skin correlated negatively with copper and with plasma total hydroperoxides. To conclude, the systemic OSS, determined using a large number of biomarkers, was always significantly increased in cured COVID-19 patients during their recovery phase. The less costly evaluation of TAC using an electrochemical method could potentially represent a good alternative to the individual analysis of biomarkers linked to pro-oxidants.

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Section: (C) Paot ® -Scores and Correlations With Os Plasma Biomarkersmentioning

confidence: 58%

A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity

Pincemaïl

Rousseau

Kaux³

et al. 2023

Biomedicines

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“…The authors found that there was no statistically significant association between facial typology and gingival biotype. Polizzi et al, in their report, have underlined the fundamental role of Myeloperoxidase in the alveolar bone loss during periodontitis [13], while Byun et al have shown the role exerted of periodontitis in patients that undergo tonsillectomy [14].…”

Section: Periodontal Diseasementioning

confidence: 99%

Oral Health and Related Factors Associated with General Health and Quality of Life

Isola

2020

Applied Sciences

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Oral well-being is an integral part of individual general health. The mouth and teeth are, in fact, part of our body, increasingly characterizing personal identity. Oral diseases are a public health problem that has a growing prevalence. Oral pathologies can occur in childhood, and as they have a chronic and progressive course, if not properly treated, they can affect the relational, psychological, and social skills of an individual. The population most affected are those with a low socio-economic level, so much so that the presence of diseases of the oral cavity is considered a marker of social disadvantage. In this regard, much effort is needed from scientists, and their applied sciences, in order to give the knowledge required for public health personal to take note of the seriousness of the situation and to start changing the way we deal with the problem.

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“…The study by Polizzi et al [35] presented that patients with coronary heart disease demonstrated significantly elevated salivary and plasma levels of MPO, regardless of periodontal status. Based on the multivariate regression analysis, in these patients, salivary MPO concentrations could be predicted by CRP and total cholesterol levels.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review

Nijakowski

Jankowski

Gruszczyński

et al. 2023

IJMS

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Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises H2O2 to generate molecules with high bactericidal activity. While MPO determination in plasma is quite common, the use of saliva is still rare. Our systematic review was designed to answer the question “Are salivary levels of myeloperoxidase altered in patients with systemic diseases?”. Following the inclusion and exclusion criteria, we included twenty-six studies. Altered MPO levels in saliva were most commonly found in patients with cardiovascular and gastrointestinal diseases. Most studies concerned unstimulated whole saliva, and only a few of them stimulated, mainly by chewing paraffin. Enzyme-linked immunosorbent assay (ELISA) was the most common method for determination of MPO concentrations in saliva. Increased salivary MPO levels were more often observed for inflammatory diseases, except patients with inflammatory bowel diseases who were eligible for biologic therapy. In conclusion, MPO could be altered in the saliva of patients with systematic diseases, especially cardiovascular or gastrointestinal diseases. However, further investigations are recommended to validate these outcomes.

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Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study

Cited by 7 publications

References 66 publications

A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity

A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity

Oral Health and Related Factors Associated with General Health and Quality of Life

Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review

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