Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Population of North-West Croatia Aged 40 and Over

Pavičić-Astaloš, Jasna; Koluder, Ana; Knežević, Lana; Geber, Mia Zorić; Novak-Lauš, Katia; Csik, Tigrena; Knežević, Tamara; Milošević, Milan

doi:10.20471/acc.2016.55.03.19

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…Among Mediterranean countries, the prevalence rate we calculated was comparable to those of Croatia (3.6%) [18], Salnés Eye Study (6.5%) [19], Central Anatolia (5.7%) [20], Eskisehir of Turkey (5.0%) [21], and Eastern Mediterranean of Turkey (7.2%) [22]. However, higher prevalence rates were detected in Greece [23,24] with the highest reported rate of 24.3% among the northwest population of Epirus [25], northeast and northwest regions of Spain (13.2 and 18.9%, respectively) [26,27], Tunisia (12.5%) [28], and Black Sea region of Turkey (12.2%) [29].…”

Section: Discussionsupporting

confidence: 62%

Exfoliation Syndrome in Egypt: Prevalence and Association with Cataract in a Large Cohort

et al. 2021

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Introduction: Exfoliation syndrome is an agerelated disease leading to ocular and systemic complications. We aimed to evaluate the prevalence of exfoliation syndrome (XFS) in Egypt and its association with cataract as one of its comorbidities. Methods: In a retrospective, hospital-based study, 155,032 Egyptians aged over 40 years from all 27 Egyptian governorates were evaluated for the prevalence of XFS and cataract in the period between January 2015 and June 2020. Results: A total of 2448 (1.6%) of the studied subjects had XFS. Their mean age was 71.2 ± 9.62 years which was significantly higher than those of subjects with no XFS. Men comprised 1348 (55.1%) of those diagnosed with XFS and this association was statistically significant (OR 1.57, 95% CI 1.45-1.70).Considering the ratio between subjects in our cohort from each region and its real population, the overall corrected prevalence in Egypt was 4.49% (Territorial regions 6.89%, Upper Egypt 5.51%, Lower Egypt 4.38%, and Greater Cairo 3.29%). Among all subjects with XFS, cataract was found in 2150 subjects (87.8%) and XFS represented 6.4% of all subjects diagnosed with cataract in our cohort (n = 33,610). Among subjects with no cataract (n = 121,422), 298 subjects had XFS (OR 0.04, 95% CI 0.03-0.04). Conclusion: Egypt has a moderate XFS prevalence compared to other countries. There is a strong association between XFS and cataract, and XFS was more common in elderly males. The results can be explained by differences in diet, ethnicity, climate, and maybe other factors.

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Section: Discussionsupporting

confidence: 62%

Exfoliation Syndrome in Egypt: Prevalence and Association with Cataract in a Large Cohort

et al. 2021

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“…In the current study the prevalence of PEG was 110(37.2%), and the prevalence of advanced glaucoma cases from them was 84(28.4%), and although showed statistically insignificant relationship with age and with sex, there was an increase in prevalence of PEG and advanced glaucoma with increasing age and slightly more in males, this result was comparable to results of Jasna Pavičić-Astaloš, et al (Pavičić-Astaloš et al, 2016) who showed the prevalence of PEG to be 23.6% with no sex difference, also the result of Seng Lee (2015) in Singapore ( Lee, Wong, & Ho, 2015) showed that the mean age for PEX patients with or without PEG had no statistically significant difference, and there were statistically significant more males having PEG than females, on the other hand, Jonas, et al, (Jonas et al, 2013) reported that after age adjustment for a multivariate analysis; PEX was not related to open-angle glaucoma. Another study was done by Tanushree and Gowda, (2014) in India, they examined 100 patients diagnosed with PEX and screened them for glaucoma, 17.0% of them had PEG, 10 (58.8%) was male and 7(41.2%) were females, who also reported that, although the prevalence of PEX was higher in females, PEG was more in male.…”

Section: Discussionsupporting

confidence: 79%

Clinical Survey of Pseudoexfoliation Syndrome

Mansoor¹,

Fawzi²

2019

GJHS

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OBJECTIVE: Assess the prevalence &lrm;of PEX and identify the associated glaucoma and &lrm;cataract.&lrm; STUDY DESIGN & METHODOLOGY: A sample of 6,650 patients (age ≥40 years) that attended the single &lrm;ophthalmic private clinic for &lrm;different complaints, for five years (January 2013 until January 2018), those diagnosed with &lrm;PEX &rlm;enrolled in this study, with a total number of 296 &lrm;patients.&lrm; RESULTS: &lrm;14 (4.7%) patients with age from 40-49 years, 54(18.2%) from 50-&lrm;&lrm;59 years, 102 (34.5%) from &lrm;&lrm;60-69 years, and 126(42.6%) equal or older &lrm;than 70 years. Close sex frequencies were observed, &lrm;with 153(51.7%) &lrm;males, and 143(48.3%) females. In the current study, the prevalence of &lrm;PEX &lrm;was 4.45% (95% confidence interval (CI), &lrm;&lrm;3.98-4.97). There was a statistically insignificant &lrm;relationship between PEG &lrm;or advanced glaucoma with age or sex, but cataract was &lrm;significantly &lrm;associated with older age and male sex.&lrm; CONCLUSION: The prevalence of Pseudoexfoliation syndrome was 4.45%, with a sharp increase after the &lrm;age &lrm;of 50 years. Although the &lrm;prevalence of PEG and advanced glaucoma increased with age, it &lrm;was &lrm;neither statistically associated with it, nor with sex&rlm;.&rlm;&lrm; Cataract prevalence &lrm;was associated &lrm;with increased age and male sex.&lrm;

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“…Literature review of positive risk factors for XFS in general [Tables 5 - 7 ][ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 ] and XFS in young subjects [ Table 8 ][ 82 83 84 85 86 87 88 89 90 91 …”

Section: Resultsmentioning

confidence: 99%

“…In the Lebanese cohort under investigation, XFS was associated with advanced age, glaucoma, habitual ocular rubbing, and longer time for cataract surgery. While advanced age [ Table 6 ],[ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] glaucoma [ Table 5 ],[ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 ] and longer surgery duration[ 100 ] are well established risk factors for XFS [ Table 5 ],[ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 <...>…”

Section: Discussionmentioning

confidence: 99%

“…Asthma and abnormal pulmonary function tests (obstructive airway disease) have been associated with XFS [ Table 6 ]. [ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] Batur et al . [ 66 ] in 60 patients with XFS without pulmonary disease detected a significant decline in pulmonary function tests versus 52 controls matched for age, gender, and smoking history.…”

Section: Discussionmentioning

confidence: 99%

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A case–cohort study of exfoliation risk factors and literature review

Mansour

Konstas

Mansour

et al. 2021

Middle East Afr J Ophthalmol

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The purpose of the study is to evaluate the risk factors associated with exfoliation in a case-cohort setting and literature review. This single-center, prospective, case-cohort study was carried out from January 2010 to April 2020 on patients operated for cataract surgery by a single surgeon in Lebanon. Forty-nine consecutive patients with exfoliation syndrome (XFS) and 62 consecutive control patients were identified and further investigated for selected systemic (diabetes mellitus, systemic hypertension, asthma, or atopy) and ocular variables (baseline vision, severity of nuclear sclerosis, glaucoma, eye rubbing, history of dry eye, or allergic eye disease). The mean baseline Snellen visual acuity was 20/283 in XFS versus 20/145 in control cases ( P = 0.012). XFS also demonstrated significantly denser nuclear sclerosis than controls ( P = 0.00958). By univariate analysis, allergic conjunctivitis (15 [30.6%] vs. 2 [3.2%]; P < 0.001), dry eye (20 [40.8%] vs. 13 [21.0%]; P = 0.0133), and habitual rubbing of the eyes (33 [67.3%] vs. 19 [30.6%]; P < 0.001) were associated with the presence of XFS. Habitual ocular rubbing was closely associated with allergic conjunctivitis (odds ratio [OR] = 13.0; 95% confidence interval [CI]: 2.8–58.8; P = 0.032). After multivariable analysis, the following variables showed significant results: glaucoma (OR = 34.5; 95% CI: 4.4–250; P = 0.010), duration of surgery (OR = 5.6; 95% CI 2.43–12.9; P < 0.001), and habitual ocular rubbing (OR = 4.42; 95% CI: 1.97–9.90; P = 0.029). This study shows a novel potential correlation between eye rubbing and XFS in a Lebanese cohort. Chronic eye rubbing induces or may exacerbate preexistent zonular damage in subjects with XFS, hence the need to better manage concurrent ocular surface disorder in these patients.

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Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Population of North-West Croatia Aged 40 and Over

Cited by 7 publications

References 34 publications

Exfoliation Syndrome in Egypt: Prevalence and Association with Cataract in a Large Cohort

Exfoliation Syndrome in Egypt: Prevalence and Association with Cataract in a Large Cohort

Clinical Survey of Pseudoexfoliation Syndrome

A case–cohort study of exfoliation risk factors and literature review

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