Producing a lycopene nanodispersion: Formulation development and the effects of high pressure homogenization

Shariffa, Y. N.; Tan, Tai Boon; Uthumporn, U.; Abas, Faridah; Mirhosseini, Hamed; Nehdi, Imededdine Arbi; Wang, Y.-H.; Tan, Chin Ping

doi:10.1016/j.foodres.2017.09.005

Cited by 42 publications

(17 citation statements)

References 38 publications

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“…Homogenization pressure of 500 bar reduced the particle size and lycopene concentration significantly, while homogenization pressure of 700-900 bar resulted in large particle sizes with high dispersibility. Homogenization pressure also effected zeta potential and turbidity of the lycopene nanodispersion (Shariffa et al, 2017). High pressure homogenization of 50-300 MPa was used to obtain stable lentil nanoemulsions.…”

Section: High Pressure Valve Homogenization Methodsmentioning

confidence: 99%

Nanoemulsions and Their Potential Applications in Food Industry

Aswathanarayan

Vittal

2019

Front. Sustain. Food Syst.

315

157

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Nanoemulsions have small droplet size and are kinetically stable colloidal systems. They have enhanced functional properties in comparison to conventional emulsions. The composition and structure of the nanoemulsions can be controlled for the encapsulation and effective delivery of bioactive lipophilic compounds. Nanoemulsions have potential application in the food industry for the delivery of nutraceuticals, coloring and flavoring agents, and antimicrobials. The nanoemulsion formulations of active ingredients can be used for developing biodegradable coating and packaging films to enhance the quality, functional properties, nutritional value, and shelf life of foods. This review focuses on preparation of food grade nanoemulsions using high-energy methods and low-energy approaches and their characterization for physical properties, stability, and microstructure. The application of nanoemulsion formulations for sustainable food processing and improving the delivery of functional compounds, such as colorants, flavoring agents, nutraceuticals, and preservatives or antimicrobial agents in foods has been discussed.

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Section: High Pressure Valve Homogenization Methodsmentioning

confidence: 99%

Nanoemulsions and Their Potential Applications in Food Industry

Aswathanarayan

Vittal

2019

Front. Sustain. Food Syst.

315

157

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“…Instead, Tween 80 and gum arabic, were less capable to confer stability against lycopene degradation and droplet aggregation. Therefore, an emulsion-based system with the smallest particle size is not always the most stable, especially in the case of lycopene [46]. This finding has been confirmed by a recent paper that studied the physicochemical stability of lycopene-loaded emulsions stabilized by plant or dairy proteins.…”

Section: Stability Of Lycopene In Emulsions: Formulation and Processimentioning

confidence: 73%

Lycopene in Beverage Emulsions: Optimizing Formulation Design and Processing Effects for Enhanced Delivery

Meroni

Raikos

2018

Beverages

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Abstract:Lycopene is a desired ingredient in food formulations, yet its beneficial effects on human health remain largely underexploited due to its poor chemical stability and bioavailability. Oil-in-water emulsions may offer multiple advantages for the incorporation and delivery of this carotenoid species. Engineering and processing aspects for the development of emulsion-based delivery systems are of paramount importance for maintaining the structural integrity of lycopene. The selection of emulsifiers, pH, temperature, oil phase, particle size, homogenization conditions and presence of other antioxidants are major determinants for enhancing lycopene stability and delivery from a food emulsion. Process and formulation optimization of the delivery system is product-specific and should be tailored accordingly. Further research is required to better understand the underlying mechanisms of lycopene absorption by the human digestive system.

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“…Preparation of EGCG-chitosan EGCG-chitosan solution was prepared by a nanoemulsi cation method [30,31]. Brie y, 8 mg of ascorbic acid was dissolved in 8 ml of deionized water and 100 mg low molecular weight chitosan was added with continuously stirring for 15 min to get a clear, transparent solution.…”

Section: Preparation Of Different Nano Formulations Encapsulating Egcgmentioning

confidence: 99%

“…Nano 2 Solid Lipid Nanoparticles (SLNPs) EGCG/lycopene nanoformulation SLNPs were prepared using a nano emulsi cation method [26,30,31] with modi cation (Fig. 1B).…”

Section: Preparation Of Different Nano Formulations Encapsulating Egcgmentioning

confidence: 99%

Enhanced Anti-Angiogenic and Anticancer Efficacy of Nanoformulated Catechin in the Chemoprevention of Skin Cancer

Sudha

Salaheldin

Darwish

et al. 2021

Preprint

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Aim: Nontoxic epigallocatechin gallate (EGCG) from green tea significantly inhibits tumors in many cancers, including melanoma. Despite the benefits, EGCG has poor stability therefore, to enhance bioavailability and anticancer efficiency, we synthesized 3 nanoformulations. Methods: In Nano 1, ZnO nanoparticles were used for encapsulating EGCG. For Nano 2, EGCG nanoformulation was prepared with co-polymeric nanoparticle-encapsulated formulations of lycopene. Olive oil nano emulsion was used in EGCG Nano 3. Evaluated physical characteristics and anticancer efficacy in chick chorioallantoic membrane tumor model. Results: Nanoformulations were stable with high EGCG encapsulation efficiency and loading. They inhibited melanoma growth effectively than free EGCG. Conclusion: Nanoformulations preparation methods efficiently prevented the loss of EGCG activity and is a favorable approach for the treatment of melanoma.

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Producing a lycopene nanodispersion: Formulation development and the effects of high pressure homogenization

Cited by 42 publications

References 38 publications

Nanoemulsions and Their Potential Applications in Food Industry

Nanoemulsions and Their Potential Applications in Food Industry

Lycopene in Beverage Emulsions: Optimizing Formulation Design and Processing Effects for Enhanced Delivery

Enhanced Anti-Angiogenic and Anticancer Efficacy of Nanoformulated Catechin in the Chemoprevention of Skin Cancer

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