Proposed anti-HSV compounds isolated from <i>Simira</i> species

Cavalcanti, Jéssica F.; Araújo, Marcelo Francisco de; Gonçalves, Priscila Baltazar; Romeiro, Nelilma C.; Romanos, Maria Teresa Villela; Vieira, Ivo José Curcino; Braz‐Filho, Raimundo; Carvalho, Mário Geraldo de; Sanches, Mirza Nalesso Gomes

doi:10.1080/14786419.2017.1375914

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…On the other hand, Harmane was shown to elucidate its capacity to counteract both seasonal human A/H1N1 virus and avian influenza A/H5N1 virus. In addition to the diverse range of Harmane, the purified Harmane from two different Simira plants, a genus of plants in the family Rubiaceae, showed antiviral potential against two different types of herpes simplex viruses (HSV-1 and HSV-2) with EC 50 (half maximal effective concentration) values of 4.90 µg/ml for HSV-1 and 71.8 µg/ml for HSV-2 35 . Regarding the influenza viruses, no evident proof of the anti-influenza properties of pure Harmane was found in the literature.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

Hegazy

Mahmoud

Elshaier

et al. 2023

Sci Rep

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The persistent evolution of drug-resistant influenza strains represents a global concern. The innovation of new treatment approaches through drug screening strategies and investigating the antiviral potential of bioactive natural-based chemicals may address the issue. Herein, we screened the anti-influenza efficacy of some biologically active indole and β-carboline (βC) indole alkaloids against two different influenza A viruses (IAV) with varied host range ranges; seasonal influenza A/Egypt/NRC098/2019(H1N1) and avian influenza A/chicken/Egypt/N12640A/2016(H5N1). All compounds were first assessed for their half-maximal cytotoxic concentration (CC50) in MDCK cells and half-maximal inhibitory concentrations (IC50) against influenza A/H5N1. Intriguingly, Strychnine sulfate, Harmalol, Harmane, and Harmaline showed robust anti-H5N1 activities with IC50 values of 11.85, 0.02, 0.023, and 3.42 µg/ml, respectively, as compared to zanamivir and amantadine as control drugs (IC50 = 0.079 µg/ml and 17.59 µg/ml, respectively). The efficacy of the predefined phytochemicals was further confirmed against influenza A/H1N1 and they displayed potent anti-H1N1 activities compared to reference drugs. Based on SI values, the highly promising compounds were then evaluated for antiviral efficacy through plaque reduction assay and consistently they revealed high viral inhibition percentages at non-toxic concentrations. By studying the modes of antiviral action, Harmane and Harmalol could suppress viral infection via interfering mainly with the viral replication of the influenza A/H5N1 virus, whilst Harmaline exhibited a viricidal effect against the influenza A/H5N1 virus. Whereas, Strychnine sulfate elucidated its anti-influenza potency by interfering with viral adsorption into MDCK cells. Consistently, chemoinformatic studies showed that all studied phytochemicals illustrated HB formations with essential peptide cleft through the NH of indole moiety. Among active alkaloids, harmalol displayed the best lipophilicity metrics including ligand efficiency (LE) and ligand lipophilic efficiency (LLE) for both viruses. Compounds geometry and their ability to participate in HB formation are very crucial.

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Section: Discussionmentioning

confidence: 99%

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

Hegazy

Mahmoud

Elshaier

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…As an example, chebulagic acid (40) and chebulinic acid (41) were observed to prevent the attachment and penetration of HSV-2 into Vero cells [43]. Curcumin (56) was detected to inhibit HSV adsorption and replication [51], while houttuynoid A (21) was noted to block viral membrane fusion [32]. Another good example is the research on prenylated phenol kuwanon X (51) [50].…”

Section: Discussionmentioning

confidence: 99%

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Treml

Gazdová

Šmejkal

et al. 2020

Viruses

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Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.

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“…harmine) oraz aptamina (ang. aptamine) [16,17]. Na przykład, harmina zaburza proces wnikania wirusa HSV do komórki i możliwość uwalniania jego cząstek potomnych, hamuje także aktywność komórkowych kinaz DYRK (ang.…”

Section: Alkaloidyunclassified

Przeciwwirusowe związki izolowane z roślin

et al. 2021

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Wirusy są wewnątrzkomórkowymi patogenami, które wykorzystują liczne procesy komórkowe oraz białka i czynniki wirusowe do swojej replikacji. Obecnie nie ma odpowiednich środków umożliwiających zwalczanie licznych zakażeń wirusowych. Skuteczny lek przeciwwirusowy nie powinien uszkadzać komórkowych procesów metabolicznych w zakażonej komórce, jak również w komórkach niezainfekowanych. Rośliny stanowią potencjalne źródło czynników przeciwwirusowych, takich jak: alkaloidy, flawonoidy, kwasy fenolowe, fenylopropanoidy, ligniny, terpenoidy, chininy, taniny, tiofeny, poliacetyleny czy białka. Niektóre z tych czynników wykazują szerokie spektrum aktywności przeciwwirusowej.

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Proposed anti-HSV compounds isolated from Simira species

Cited by 6 publications

References 15 publications

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Przeciwwirusowe związki izolowane z roślin

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