Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review

Chen, Yung Chia; Chen, Ying Hui; Pan, Bo; Chang, Ming‐Chih; Huang, Bu Miin

doi:10.1016/j.jfda.2016.10.020

Cited by 58 publications

(39 citation statements)

References 74 publications

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“…Membranes were then washed three times with TBST and incubated for 1 h with the appropriate HRP conjugated secondary antibodies. Bands were detected using ECL substrate and the UVP EC3 BioImaging system (UVP, LLC, Phoenix, AZ, USA) (32)(33)(34). Quantification of the western blotting data was performed using ImageJ version 1.50 software (National Institutes of Health, Bethesda, MD, USA).…”

Section: Chemicalsmentioning

confidence: 99%

Arsenic compounds induce apoptosis through caspase pathway activation in MA‑10 Leydig tumor cells

Chen

Chang

et al. 2019

Oncol Lett

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The incidence of testicular cancer is increasing worldwide. Leydig cell tumors represent one type of sex cord-stromal testis malignancy, which tend to respond unfavorably to chemotherapies. Identifying more efficient treatment strategies is therefore crucial for patients. The present study aimed to investigate the apoptotic effects of arsenic compounds and their underlying mechanisms. The results indicated that sodium arsenite and dimethylarsenic acid induced apoptosis of the murine Leydig tumor cell line, MA-10. These apoptotic effects were characterized morphologically by membrane blebbing and cell detachment assays, biochemically using a cell viability assay, and cytologically by flow cytometry analysis. Western blotting demonstrated that caspases-3,-8 and-9, and poly(ADP-ribose) polymerase protein levels were increased compared with untreated MA-10 cells; however, the caspase inhibitor, Z-VAD-fmk, reversed these effects. In conclusion, the present study has shown that sodium arsenite and dimethylarsenic acid may activate the intrinsic and extrinsic caspase pathways, and induce MA-10 cell apoptosis. These results suggest that sodium arsenite and dimethylarsenic acid may represent novel approaches to treat clinically unmanageable forms of testicular cancer.

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Section: Chemicalsmentioning

confidence: 99%

Arsenic compounds induce apoptosis through caspase pathway activation in MA‑10 Leydig tumor cells

Chen

Chang

et al. 2019

Oncol Lett

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“…7 Kısaca, Cordyceps preparatları ve bileşiklerinin antikanser, antioksidan, antiinflamatuar ve antimikrobiyal aktivitelerinin yanı sıra hepatik, renal, kardiyovasküler, solunum, sinir, cinsel ve immünolojik sistemlere etkisi dikkate değer bulunmaktadır. 17…”

Section: Farmakoloji̇k Etki̇lerunclassified

Cordyceps Sinensis (Berk.) Sacc. and Its Pharmacological Importance

Önder¹,

Çınar²,

Canatan³

2019

J Lit Pharm Sci

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Cordyceps sinensis (Berk.) Sacc. ve Farmakolojik Açıdan Önemi Ö ÖZ ZE ET T Cordyceps sinensis, Uzak Doğu'da özellikle Çin, Nepal ve Tibet'in yüksek platolarında yetişen çok değerli ve nadir bulunan tıbbi bir mantardır. Çin'de MS 620'ye kadar uzanan yazılı literatürde; büyülü bir yaratık, hayvan ve bitki olarak tanımlanan tür, Geleneksel Çin Tıbbında yüzyıllardan beri ilaç olarak kullanılmaktadır. Caterpillar fungus, Dong Chong Xia Cao, Çin tırtıl mantarı veya Yarsagumba olarak da bilinen Cordyceps sinensis, taksonomik olarak Ascomycota (keseli mantarlar) sınıfı, Clavicipitaceae familyasında yer alan entomopatojen bir canlı türüdür. Meyveli gövdenin morfolojik özellikleri; hafif silindirik, çubuk şeklinde, renk olarak da sarımsı-turuncu veya kırmızımsı-turuncu renge sahip olarak tanımlanmaktadır. Bu mantar geleneksel olarak ishal, baş ağrısı, öksürük, romatizma, karaciğer ve böbrek hastalıkları, diyabet, yorgunluk gibi hastalıklar için binlerce yıldan beri kullanılmaktadır. Kimyasal içeriğinde bulunan nükleozitler, polisakkaritler, steroller, proteinler, vitaminler, mineraller sayesinde tıbbi olarak antitümör, immünomodülatör, antioksidan, antidiyabetik, cinsel gücü artırıcı, yorgunluk giderici, böbrek ve karaciğer fonksiyonlarını iyileştirici etkiler göstermesinin yanı sıra besin değeri olarak da önemli bir tıbbi mantardır. Kimyasal içeriğine bakıldığında, sahip olduğu nükleozit grubuna ait olan kordisepin ve kordisepik asit başlıca bileşenler olarak öne çıkmaktadır. Cordyceps sinensis, son yıllarda tüm dünyada popüler doğal ürünler arasında yerini almıştır. Özellikle antioksidan ve immünomodülatör etkileri nedeniyle, antitümör olarak kullanımı göze çarpmaktadır. Bu nedenle bu çalışmada, önemli farmakolojik etkilere sahip olan ve tıbbi olarak da kullanılan Cordyceps sinensis hakkında daha detaylı bilgi verilmesi, üzerine yapılmış olan araştırmaların sunulması amaçlanmıştır.

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“…[15][16][17] Cordycepin (3'-deoxyadenosine; C 10 H 13 N 5 O 3 ) ( Figure 1A), a major bioactive compound of Cordyceps sinensis, has a wide range of biological effects regulating steroidogenesis, inflammation, and platelet aggregation. [18][19][20][21] Besides, studies have shown that cordycepin exerts a large variety of antitumor abilities. 22,23 However, it is rare on the investigation of antitumor effect of cordycepin on testicular tumor.…”

Section: Introductionmentioning

confidence: 99%

Cordycepin‐induced unfolded protein response‐dependent cell death, and AKT/MAPK‐mediated drug resistance in mouse testicular tumor cells

et al. 2019

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Testicular cancer is the most commonly diagnosed cancer in men at 15‐44 years of age, and radical orchidectomy combined with chemotherapy is currently considered as the standard treatment. However, drugs resistance and side effects that impact the quality of life for patients with testicular cancer have not been markedly improved in recent decades. In this study, we characterized the pharmacological exacerbation of the unfolded protein response (UPR), which is an effective approach to kill testicular cancer cells, by carrying out a clustering analysis of mRNA expression profiles and the immunobloting examination of cordycepin‐treated MA‐10 cells. The UPR is executed in response to endoplasmic reticulum stress to complement by an apoptotic response if the defect cannot be resolved. Results showed that cordycepin significantly modulated FoxO/P15/P27, PERK‐eIF2α (apoptotic), and the IRE1‐XBP1 (adaptive) UPR pathways. Interestingly, a fraction of MA‐10 cells survived after cordycepin treatment, the AKT, LC3 I/II, and MAPK signaling pathways were highly induced in attached cells as compared to the suspended cells, illustrating the drug resistance to cordycepin via activating AKT and MAPK pathways in MA‐10 cells. In summary, PERK‐eIF2α signaling pathway is required for pro‐apoptotic UPR in MA‐10 cell death following cordycepin treatment, suggesting a potential therapeutic application in treating testicular cancer. However, activation of AKT and MAPK pathways could possibly result in drug resistance to cordycepin in MA‐10 cells.

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Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review

Cited by 58 publications

References 74 publications

Arsenic compounds induce apoptosis through caspase pathway activation in MA‑10 Leydig tumor cells

Arsenic compounds induce apoptosis through caspase pathway activation in MA‑10 Leydig tumor cells

Cordyceps Sinensis (Berk.) Sacc. and Its Pharmacological Importance

Cordycepin‐induced unfolded protein response‐dependent cell death, and AKT/MAPK‐mediated drug resistance in mouse testicular tumor cells

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