Investigation of the 5′ flanking region and exon 3 polymorphisms of IGF-1 gene showed moderate association with semen quality in Sanjabi breed rams

Bakhtiar, Roya; Abdolmohammadi, Alireza; Hajarian, Hadi; Nikousefat, Zahra; Kalantar-Neyestanaki, Davood

doi:10.1016/j.theriogenology.2017.08.023

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…(2012 ) in Chinese and European breeds found different genotypic and allelic frequency for the two polymorphisms at the 5′ UTR region. In Texel and Dorset breed indeed a similar frequency than in this study was reported, while Chinese breeds have shown a lower G frequency, i.e., in agreement with observation reported by Darwish, El-Shorbagy, Abou-Eisha, El-Din and Farag (2017 ) and by Bakhtiar et al. (2017 ) in Egyptian and Iranian sheep, respectively.…”

Section: Discussionsupporting

confidence: 93%

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Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

Luridiana

Mura

Veronica

et al. 2020

Veterinary and Animal Science

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Highlights IGF-1 gene plays an important role in regulating reproduction in ruminants. Here three SNPs were found in the IGF-I gene in Sarda sheep. The found SNPs were related to reproductive performance and milk yield. This results could be used to improve the reproductive performances and milk yield in Sarda sheep.

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Section: Discussionsupporting

confidence: 93%

“…(2010 ) in Italian breeds. Instead, Bakhtiar et al. (2017 ) in Iranian sheep found an allelic and genotypic frequency different from Italian sheep.…”

Section: Discussionmentioning

confidence: 71%

Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

Luridiana

Mura

Veronica

et al. 2020

Veterinary and Animal Science

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“…The allele frequency was 0.94 for the G and 0.06 for the C allele in Sarda sheep [24]. Bakhtiar and coauthors [25] estimated A and B allele frequencies in the Sanjabi sheep as 0.52 and 0.48, respectively. The allele frequency of the A and B Kivircik sheep was 0.915 and 0.085, respectively [26].…”

Section: Igf-i Locus Polymorphismmentioning

confidence: 99%

Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

Bayraktar

Shoshin

2021

Braz. arch. biol. technol.

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IGF-I and IGFALS play a vital stimulator role in skeletal growth, cell differentiation, metabolism, and other physiological processes. A total of 65 (male and female) animals were used in the study. Animals were measured for growth traits at birth weight, weaning weight, and weights at 6 months. The average daily gain (ADG) was calculated from birth to weaning (ADG1) and from birth to 6th month (ADG2). PCR-RFLP analysis was used to detect IGF-I polymorphism at the 5' regulatory region and IGFALS at Exon 1. Three genotypes (AA, AB and BB) were observed for IGF-I/BfoI locus with allele and genotype frequency 0.79(A) and 0.21(B); 0.71(AA), 0.15(AB) and 0.14(BB). Also, three genotypes (AA, AB and BB) were found for IGFALS/HinfI site with allele and genotype frequency as 0.22(A) and 0.78(B); 0.11(AA), 0.23(AB) and 0.66(BB). The genes were in agreement with Hardy-Weinberg equilibrium (p>0.05). Association analysis suggested that IGF-I and IGFALS significantly affected the growth traits (P<0.05). In terms of birth weight, The AA genotypes of IGF-I were higher than AB and BB. The AB genotype in terms of IGF-I had higher ADG2 compared with other genotypes. The AA genotype of the IGFALS gene was higher in terms of birth weight than other genotypes. In addition, the BB genotype was higher ADG1 than AA and BB. It is suggested that polymorphism of the IGF-I and IGFALS genes may be a potential molecular marker for growth traits in Hamdani sheep.

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“…An 18-bp indel in the 5′ untranslated region (5′ UTR) of pig SRY-box transcription factor 9 ( SOX9 ) gene was significantly associated with boar testis weight ( p < 0.05) and controlled the expression of SOX9 [10]. Additionally, a single nucleotide polymorphism (SNP) locus within Exon3 of the insulin-like growth factor 1 ( IGF-1 ) gene significantly affected the semen quality ( p < 0.05) in Sanjabi rams [11].…”

Section: Introductionmentioning

confidence: 99%

Genetic Effects of Single Nucleotide Polymorphisms in the Goat GDF9 Gene on Prolificacy: True or False Positive?

Wang

Yang

Zhang

et al. 2019

Animals

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Simple SummaryAs an important regulator factor, which was secreted by female oocytes, the growth differentiation factor 9 (GDF9) plays an essential role during the growth and differentiation of ovarian follicles. Single nucleotide polymorphisms (SNPs) within the GDF9 gene have been found to be involved in reproductive traits in livestock, and some of these mutations have been used as the effective makers in animal molecular breeding. However, it is remarkable that the SNPs of the goat GDF9 gene have not been systematically sorted and analyzed from the reported studies, which leads to an inability to find effective loci that could be applied in improving the prolificacy of goats via the molecular breeding method. In this study, we gathered and sorted 45 SNPs of the goat GDF9 gene from all relevant studies and the National Center for Biotechnology Information Search database (NCBI), and especially analyzed and discussed the relationship between part controversial and potentially effective SNPs and the reproductive traits. The results indicated that non-synonymous SNPs A240V, Q320P, and V397I and synonymous SNPs L61L, N121N, and L141L were six “true” positive SNPs in improving goat fertility. Nevertheless, the regulation pathways and the specific mechanism of these six SNPs on goat fecundity are not clear, which still need further study in more goat breeds and a large sample size. These results provided an effective tool for follow-up research studies on the molecular genetic breeding of goats’ reproductive traits.AbstractGoat reproductive traits are complex quantitative traits controlled by polygenes and multipoint. To date, some high-fertility candidate genes in livestock have been unearthed and the growth differentiation factor 9 (GDF9) gene is one of them, which plays a crucial role in early folliculogenesis. According to the relevant previous studies and the National Center for Biotechnology Information Search database (NCBI), a total of 45 single nucleotide polymorphisms (SNPs) have been detected in the goat GDF9 gene, but which one or which ones have important effects on goat fecundity is still uncertain. Hence, in order to find effective molecular markers for goat genetic breeding and accelerate the goat improvement, this study summarized and classified the above 45 SNPs into four kinds, as well as compared and analyzed the same SNP effects and the different SNPs linkage effects on the reproductive traits in different goat breeds. Since there were many SNPs in the goat GDF9 gene, only 15 SNPs have been identified in more than 30 goat breeds worldwide and they showed different effects on the litter size. Therefore, this study mainly chose these 15 SNPs and discussed their relationship with goat productivity. Results showed that three non-synonymous SNPs A240V, Q320P, and V397I and three synonymous ones L61L, N121N, and L141L played a “true” role in the litter size trait in many goat breeds around the world. However, the regulatory mechanisms still need further research. These results provide an effective tool ...

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Investigation of the 5′ flanking region and exon 3 polymorphisms of IGF-1 gene showed moderate association with semen quality in Sanjabi breed rams

Cited by 9 publications

References 38 publications

Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

Genetic Effects of Single Nucleotide Polymorphisms in the Goat GDF9 Gene on Prolificacy: True or False Positive?

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