Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

Luridiana, Sebastiano; Mura, Maria Consuelo; Veronica, Di Stefano Maria; Pulinas, Luisa; Cosso, Giovanni; Nehme, Michella; Carcangiu, Vincenzo

doi:10.1016/j.vas.2019.100084

Cited by 13 publications

(16 citation statements)

References 31 publications

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“…And (Deng et al, 2010) in a study on two breeds of Chinese goats (Guanzhong and Xinony saanen), with a higher percentage of GG genotype (0.64%) than AG genotype (0.36%). This is what was observed by (Sebastiano et al, 2020) in a study on Sarda sheep, where the percentage of genotypes CC 0.85 was the highest for the rest of the structures CG and GG (0.11, 0.4), respectively. And (Di Stefano., 2017) in a study on the Sarda sheep breed, the genotypes GG, AG and AA were (0.89, 0.10,0.01), respectively, while the frequency of the G allele was (0.94) and the frequency of the A allele was (0.06), and these percentages were identical to the allele ratios G and A in this study.…”

Section: Distribution Of Genotypes and Alleles Frequencies Of The Stu...supporting

confidence: 86%

“…As these results were consistent with several studies that recorded a significant superiority of genotypes in milk production, as (Di Stefano., 2017) indicated a significant superiority (p <0.05) in 5-UTR for the daily milk production trait , as the composition outperformed The genotype GG (1.99 ± 0.52) on the GC and CC genotypes (1.64 ± 0.3, 1.58 ± 0.05) respectively in Sarda sheep. (Sebastiano et al, 2020) indicated the presence of three genotypes for the 5-UTR region (CC, CG, GG), which were significantly (P < 0.05) superior to the individuals carrying the CC genotype in three stages of daily milk production (1800, 1580 (1990) compared to the carrier individuals). This was contrary to what was observed by (Deng et al, 2010) on two Chinese goats (Guanzhong and Xinony saanen), as there were no significant differences in both genotypes GG and AG for the same region 5-UTR.…”

Section: Relationship Of the Polymorphism Of 5-utr Of Igf-1 Gene To D...mentioning

confidence: 96%

“…In another study, two genotypes (GG and AG) were found in the region same (5-UTR) in two breeds of Chinese goats (Guanzhong and Xinony saanen)(Deng et al, 2010). In Sarda sheep, it was found that there are three Genotypes: GG, GA, and AA at position 857(Di Stefano., 2017 andSebastiano et al, 2020). Figure(3) shows the target segment sequence for the 5-UTR, where we find a change wild allele (A) to mutant allele (G) at sequence 182 (shaded in blue) from the beginning of the forward initiator (in yellow) and represents a homozygous substitution mutation of the purine base substitution A to the base of the purine G.…”

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confidence: 99%

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Relationship of polymorphism of untranslated region (5-UTR) of the insulin-like growth factor (IGF-1) gene with milk production and growth traits in local black goats

Ali

Mahdi

2022

ijhs

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The study was conducted on a sample of 34 local goats in a private field of a breeder in Canaan sub-district / Diyala governorate. Laboratory work was conducted in the laboratory of the College of Agriculture - University of Diyala and the Office of Scientific Advancement - Al-Harithiya – Baghdad- Iraq for the period from 13/11/2021 to 1/5/ 2022 with aim of studying the genetic polymprphism of the untranslated region (5-UTR) of the IGF-1 gene and its relationship to milk traits (daily milk production - DMY and total milk production - TMY) and growth traits (birth weight -BWT, weaning weight -WWT and weight gain pre-weaning-WG). The results of the study showed a highly significant (P < 0.01) between the genotypes, as two genotypes of 5-UTR were observed, namely, GG and AG, with frequency distribution ratios of 91% and 9%, respectively, while the frequency of the G allele was more) 94%) compared frequency A allele (6%) in the studied sample.

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Section: Distribution Of Genotypes and Alleles Frequencies Of The Stu...supporting

confidence: 86%

Section: Relationship Of the Polymorphism Of 5-utr Of Igf-1 Gene To D...mentioning

confidence: 96%

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confidence: 99%

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Relationship of polymorphism of untranslated region (5-UTR) of the insulin-like growth factor (IGF-1) gene with milk production and growth traits in local black goats

Ali

Mahdi

2022

ijhs

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“…A similar type of polymorphism at the IGF-1 locus was discovered using the RFLP method in Egyptian small ruminant breeds, where the genotype frequencies were 53.66%, 30.49%, and 15.85% for GG, CG, and CC with allele frequencies of G (68.9%) and C (31.1%). Sebastiano et al (2020) identified allele and genotype frequencies with the SNPs method in the Sarda sheep breed at position g184028491. The result showed C and G allele frequencies were 90 and 10%, and the genotype frequencies of CC, CG, and GG were 85%, 11%, and 4%, respectively.…”

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confidence: 99%

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

Malewa

Awaluddin

2022

Trop. Anim. Sci. J.

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This study aims to examine the polymorphisms of the IGF-1 gene associated with body weight and size. A total of 60 sheep from different farm locations in Palu City (Villages of Taipa, Poboya, Kawatuna, and Petobo), Central Sulawesi, Indonesia, were used. The variables observed were adult body weight and measurements, such as shoulder height, body length, humerus length, radiusulna length, metacarpus length, hip height, femur length, tibial length, and metatarsus length as phenotypic characteristics. IGF-1 gene polymorphisms were analyzed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) with Bsp143|| as a restriction enzyme. These gene polymorphisms were calculated using the allele and genotype frequency approach, as well as the Polymorphic Informative Content (PIC). Genotype associations with body weight and bone size were analyzed using the General Linear Model analysis method. The PCR-RFLP analysis results showed the presence of polymorphisms with the frequency and genotypes of GG (21.7%), GC (68.3%), and CC (10%). Furthermore, the frequencies of G (55.8%) and C (44.2%) genes with a 49.32% polymorphism rate (PIC) were not in the Hardy-Weinberg equilibrium (p<0.05).In conclusion, the IGF-1 gene polymorphism was detected in Palu sheep with an insignificant effect on body weight and bone size.

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“…Recently, Lestari et al (2020) identi ed SNP (g5752G→C) at intron 4 of IGF-I gene in Kejobong goats, where two genotypes GG and CC found to be signi cantly associated with body weight. In addition, Sebastiano et al (2020) found two SNPs at 5' UTR and exon 3 of IGF-1gene showed a signi cant association with reproductive traits and milk production in Sarda dairy sheep.…”

Section: Introductionmentioning

confidence: 92%

Association of PRLR, IGF1 and LEP genes polymorphism with milk production and litter size in Egyptian Zaraibi goat

El-Shorbagy

Abdel-Aal

Mohamed

et al. 2022

Preprint

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This study aimed to detect specific nucleotide polymorphisms in Prolactin receptor (PRLR), Insulin like growth factor (IGF1) and Leptin (LEP) genes and their correlation with milk production (MP) and litter size (LS) traits in Zaraibi goat. PCR-SSCP products of different patterns of each gene were sequenced and aligned to reveal two single nucleotide polymorphisms (SNPs) (T>C) and (G>A) in 3’UTR of PRLR gene and registered with accession numbers OM418863 for TT and OM418864 for CT, while (G>A) SNP was registered as OM418861 for GG and OM418862 for AG in exon 10. TT, CT, AG and GG genotypes were distributed in the studied animals with frequencies 0.43, 0.57, 0.65 and 0.35, respectively. While alleles C, T, A and G frequencies were 0.28, 0.72, 0.32 and 0.68, respectively. CT and AG genotypes associated significantly (P<0.05) with higher MP and LS respectively. By studying the haplotypes of PRLR, C-A and T-A were associated with the highest and the lowest level of MP respectively. For LS, T-A and C-G showed significant correlation with the highest and the lowest rate respectively. Regarding IGF1 gene, two SNPs were detected; T74C at exon 4 which registered as (OM418860), and combined SNPs as ins. G470, A531G and T534C (PP genotype) at 5’ flanking region that registered as (OM418859). For LEP, only one SNP was found in intron 2 (G281A) which submitted to GenBank as (OM418855). All detected SNPs have shown to be involved in regulating the MP or LS as reproductive traits in goat.

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Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

Cited by 13 publications

References 31 publications

Relationship of polymorphism of untranslated region (5-UTR) of the insulin-like growth factor (IGF-1) gene with milk production and growth traits in local black goats

Relationship of polymorphism of untranslated region (5-UTR) of the insulin-like growth factor (IGF-1) gene with milk production and growth traits in local black goats

Polymorphisms of Palu Sheep IGF-1 Gene and Their Relationship with Skeletal Growth

Association of PRLR, IGF1 and LEP genes polymorphism with milk production and litter size in Egyptian Zaraibi goat

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