Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer

Khan, Iliyas; Kumar, Hitesh; Mishra, Gaurav; Gothwal, Avinash; Kesharwani, Prashant; Gupta, Umesh

doi:10.2174/1381612823666170829164828

Cited by 14 publications

(8 citation statements)

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“…To address the low permeability of the drug across the cell membrane, incorporation of the hydrophilic drug (MT) into lipophilic carrier system, like liposomes, polymeric mixed micelles, nanoparticles such as NLCs, SLNs, Nano-diamond NPs, gold NPs, Albumin NPs, graphene oxide NPs, iron NPs etc. have been extensively reported [98][99][100][101].…”

Section: Nano Formulation Development Strategy Of Mitoxantronementioning

confidence: 99%

Overview of Mitoxantrone-a Potential Candidate for Treatment of Breast Cancer

et al. 2022

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Anthraquinones are one of the popular classes of aromatic compounds which possess potential anticancer properties by suppressing the nucleic acid formation and proteins essential to the survival of cancerous cells. Mitoxantrone (MT) is an antibiotic and antineoplastic agent belonging to the anthracycline class of compounds which exhibit minimal incident of drug resistance. It is a synthetic anticancer drug, bound to enzyme topoisomerase IIα inhibitor, and intercalates DNA topoisomerase IIα, preventing re-ligations in DNA strands fragmentation and disruption of DNA repair. The expression of this enzyme was used tumor cells marker because of its key function in cell proliferation. The cleavable complex of topoisomerase IIα is hypothesized to damage the DNA and may enhance apoptosis in tumor cell proliferation. The susceptibility of cells to mitoxantrone is associated with cell topoisomerase II α protein and lowered resistance in breast cancer line cell lines to topoisomerase IIα inhibitors. MT is an ABC-transporter in breast cancer, also designated to be associated with “Breast cancer resistance protein” (BCRP) and it is also a cell cycle non-specific anti-cancer drug and P-glycoprotein substrate. Multiple drug resistance is one of the major drawbacks of this drug which can be avoided by reducing the efflux of the drug from cancer cells by formulating drug by using lipophilic carriers. This manuscript discusses about MT's source, chemistry, physicochemical properties, anti-cancer effects of mitoxantrone and possible pathways, Mitoxantrone targeting topoisomerase II inhibitor for cancer therapy and its mechanism, Various Nano formulation development strategy, toxicity profile, and a few patents related information.

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Section: Nano Formulation Development Strategy Of Mitoxantronementioning

confidence: 99%

Overview of Mitoxantrone-a Potential Candidate for Treatment of Breast Cancer

et al. 2022

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“…Polymeric nanoparticles include solid colloidal nanoparticles sized from 10 to 1,000 nm consisting of either synthetic or natural polymers (Crucho and Barros, 2017;Khan et al, 2017). These nanostructures are believed to have improved performance in energy storage compared to the bulk conducting polymers due to their high electrical conductivity, high electrochemical activity, large surface area, and short path lengths for the transport of ions (Pan et al, 2010).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

140

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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“…One might find it interesting that even the most recent reference reviews [ 171 , 172 ] on the specific theme of nanocarriers suitable for lung cancer treatment recognize the great number of doubts and burdens that are still to be considered in this niched research area. At the moment, only a few experiments have apparently been conducted with the specific aim of targeting lung cancer via nanoparticles, with the great majority of them focusing rather on the usage of these nano-sized carriers in oncology therapies [ 173 ].…”

Section: Nanocarriers Suitable For Lung Cancer Treatmentmentioning

confidence: 99%

The Nanosystems Involved in Treating Lung Cancer

Crintea

Duţu

Samaşcă

et al. 2021

Life

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Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

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Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer

Abstract: The present review is focused on recent developments regarding polymeric nanocarriers, such as polymeric micelles, polymeric nanoparticles, dendrimers, liposomes, nanoshells, fullerenes, carbon nanotubes (CNT) and quantum dots, etc. for their recent advancements in breast cancer therapy.

Cited by 14 publications

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Overview of Mitoxantrone-a Potential Candidate for Treatment of Breast Cancer

Overview of Mitoxantrone-a Potential Candidate for Treatment of Breast Cancer

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

The Nanosystems Involved in Treating Lung Cancer

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