Chemical characterization, toxicology and mechanism of gastric antiulcer action of essential oil from Gallesia integrifolia (Spreng.) Harms in the in vitro and in vivo experimental models

Arunachalam, Karuppusamy; Balogun, Sikiru Olaitan; Pavan, Eduarda; Almeida, Guilherme Vieira Botelho de; Oliveira, Ruberlei Godinho de; Wagner, Theodoro Marcel; Filho, Valdir Cechinel; Martins, Domingos Tabajara de Oliveira

doi:10.1016/j.biopha.2017.07.064

Cited by 35 publications

(22 citation statements)

References 86 publications

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“…These results were different of the values already found in others studies [26][27][28]. We hypothesized that the corn oil and other vegetable oil may be altering liver physiology by alteration of triglycerides synthesis and hepatic lipid peroxidation in some conditions [29][30][31][32][33]. Thus, these ndings showed that the CAP presented neither hepatotoxic effect nor renal toxicity, since that there is no signi cant change in urea and creatinine.…”

Section: Biochemical Changes Upon Chloramidaphen Exposurecontrasting

confidence: 72%

Regioisomerism and 5-substitution as promising approaches for molecular design of safer acetaminophen derivatives

Gustavo¹,

Morais²,

Ferreira³

et al. 2021

Preprint

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Acetaminophen is a widely used over-the-counter analgesic and antipyretic drug, but in large doses can produce hepatic and/or renal injury. Based on its human toxicity by N-acetyl-p- benzoquinone imine formation as reactive toxic intermediate, an acetaminophen regioisomer substituted on 5-position, named chloraminophen, was proposed. The electron and hydrogen transfers were related to the ionization potential and bond dissociation energies on phenol and acetamide moieties. These calculations were performed by using quantum chemical calculations at the density functional theory (DFT/B3LYP) with the 6-311 + + G(d,p) basis set. For acute toxicity study was performed using a single dose test of 300 or 2000 mg/kg. No differences were found in the biochemical parameters except for aspartate aminotransferase levels, probably due to corn oil used as dilution solvent. The second energy of hydrogen abstraction may have great impact on amino-phenols toxicity. The regioisomerism can be a useful strategy in drug design for safer acetaminophen derivatives.

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Section: Biochemical Changes Upon Chloramidaphen Exposurecontrasting

confidence: 72%

Regioisomerism and 5-substitution as promising approaches for molecular design of safer acetaminophen derivatives

Gustavo¹,

Morais²,

Ferreira³

et al. 2021

Preprint

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“…Despite its long clinical success, growing evidence has shown that PM can produce adverse effects on the stomach, liver, and kidney. Besides its nonselective-inhibitory effect on COX enzymes, a considerable amount of literature has suggested that the toxicity of PM works through oxidative stress to produce its damaging effects on the stomach, liver, and kidney [ 1 , 5 , 7 , [31] , [32] , [33] , [34] , [35] ]. Oxidative stress is a process that is initiated through well-known ROS (superoxide anion, O2 • − ; hydrogen peroxide, H 2 O 2 ; hydroxyl radical, OH • ) and reactive nitrogen species, RNS (nitric oxide, NO and peroxynitrite, ONOO − ), which are up-regulated due to exhaustion of endogenous antioxidant molecules.…”

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Abdeen¹,

Abdelkader²,

Elgazzar³

et al. 2020

Biomedicine & Pharmacotherapy

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Highlights PM produced oxidative stress in gastric, liver, and kidney tissue. PM-induced toxicity was mediated by ROS and mitochondrial dysfunction. PM enhanced the activated caspase-3 expression. CoQ10 alleviates PM-induced gastropathy and hepato-renal damage. CoQ10 might be effective in COVID-19 treatment regimen.

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“…Ulcer inhibition of 100 mg/kg Cedrus deodara and 20 mg/kg of rabeprazole was, respectively, 41.5% and 67.7% [ 179 ]. α-Santalene rich essential oil of Gallesia integrifolia evidenced potent gastroprotective and curative effects in vivo and in vitro experimental models, which is probably due to its antioxidant, nitrergic, mucogenic, anti-secretory and anti-inflammatory effects [ 161 ]. On the other hand, the essential oil of Croton rhamnifolioides with major components spathulenol (22.5%) and 1,8-cineole (18.3%) exhibited antiulcer activity by modulation of opioid receptors and nitric oxide [ 163 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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Chemical characterization, toxicology and mechanism of gastric antiulcer action of essential oil from Gallesia integrifolia (Spreng.) Harms in the in vitro and in vivo experimental models

Cited by 35 publications

References 86 publications

Regioisomerism and 5-substitution as promising approaches for molecular design of safer acetaminophen derivatives

Regioisomerism and 5-substitution as promising approaches for molecular design of safer acetaminophen derivatives

Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

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