The Effects on Obesity Related Peptides of Laparoscopic Gastric Band Applications in Morbidly Obese Patients

Aydın, Seval; Zengin, Ulgen; Kocael, Ahmet; Orhan, Anıl; Zengin, Kağan; Gelışgen, Remise; Taşkın, Mustafa; Uzun, Hafize

doi:10.1080/08941939.2017.1280564

Cited by 12 publications

(7 citation statements)

References 37 publications

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“…Consistently, high resistin levels also correlate with increased risk of all-cause and cardiovascular death [80]. It is also remarkable that the excess of resistin is among the cytokines that define the metabolic unhealthy state, associated with obesity, as demonstrated by the decrease of circulating resistin levels after bariatric surgery [81,82].…”

Section: Specific Adipokinesmentioning

confidence: 99%

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Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

et al. 2019

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Obesity, which is a worldwide epidemic, confers increased risk for multiple serious conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Adipose tissue is considered one of the largest endocrine organs in the body as well as an active tissue for cellular reactions and metabolic homeostasis rather than an inert tissue only for energy storage. The functional pleiotropism of adipose tissue relies on its ability to synthesize and release a large number of hormones, cytokines, extracellular matrix proteins, and growth and vasoactive factors, which are collectively called adipokines known to influence a variety of physiological and pathophysiological processes. In the obese state, excessive visceral fat accumulation causes adipose tissue dysfunctionality that strongly contributes to the onset of obesity-related comorbidities. The mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. This review describes the relevance of specific adipokines in the obesity-associated cardiovascular disease.

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Section: Specific Adipokinesmentioning

confidence: 99%

“…It is tempting to hypothesize that this adipokine could contribute to the inflammatory state and increased risk for cardiovascular events characterizing patients with type 2 diabetes in a direct way rather than with diabetes itself. Plasma levels of visfatin are gradually reduced after bariatric surgery-related weight loss [82].…”

Section: Specific Adipokinesmentioning

confidence: 99%

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

et al. 2019

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“…Weight loss after bariatric surgery is mainly due to the loss of visceral fat [21], but whether the secretion of adipokines is then modulated remains to be fully established as the response varies [22][23][24] and is not always significant [25][26][27][28][29][30]. We, therefore, conducted a meta-analysis and systematic review to investigate the effect of different types of bariatric surgeries on these adipokines.…”

Section: Introductionmentioning

confidence: 99%

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

et al. 2020

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Different adipokines secreted from adipose tissue, exert a range of physiological effects. The aim of present systematic review and meta-analysis was to critically investigate the consequence of bariatric surgery on circulating adipokines, that is, adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor, and chemerin. After systematically checking the following electronic databases: ISI web of Science, Scopus and PubMed without limitation in time and language up to February 2019, a pool based on a random effect model was established. Eighty-five eligible studies were entered for quantitative analysis. Our meta-analysis revealed that circulating adiponectin increased significantly after bariatric surgery [Standardized mean difference (SMD)=1.401, 95% CI: 1.101, 1.701, p<0.001]; whilst leptin (SMD=–2.178, 95% CI: –2.433, –1.923, p<0.001), PAI-1 (–14.928 ng/ml 95% CI: –21.794, –8.063, p<0.001), and chemerin (–50.238 ng/ml 95% CI: –85.708, –14.768, p<0.001) decreased. However, serum visfatin (2.05 ng/ml, 95% CI: –5.07, 9.17, p=0.573) and resistin (–2.080 ng/ml, 95% CI: –5.352, 1.192, p=0.21) were unchanged. In conclusion, bariatric surgery is associated with a reduction in specific adipokines including leptin, chemerin, and PAI-1, whereas adiponectin is raised, adaptations that could be indicative of improved fat mass and function.

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“…Plasma apelin in obese animals and humans has a high concentration (Arica et al, 2018;Boucher et al, 2005). In 2005, Boucher et al showed that apelin was synthesized and secreted in adipocytes and that there was a close relationship between apelin and insulin in in vivo and in vitro conditions (Boucher et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

L‐carnitine improves metabolic disorders and regulates apelin and apelin receptor genes expression in adipose tissue in diabetic rats

et al. 2020

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The Effects on Obesity Related Peptides of Laparoscopic Gastric Band Applications in Morbidly Obese Patients

Cited by 12 publications

References 37 publications

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

L‐carnitine improves metabolic disorders and regulates apelin and apelin receptor genes expression in adipose tissue in diabetic rats

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