Effect of Bariatric Surgery on the Circulating Level of Adiponectin,
                    Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A
                    Systematic Review and Meta-Analysis

Askarpour, Moein; Alizadeh, Shahab; Hadi, Amir; Symonds, Michael; Miraghajani, Maryam; Sheikhi, Ali; Ghaedi, Ehsan

doi:10.1055/a-1129-6785

Cited by 41 publications

(26 citation statements)

References 133 publications

(105 reference statements)

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“…24,25 Similar results have been found in subjects after gastric bypass surgery. 9,10 Why do obese women have higher levels of inflammatory markers compared to men? Several theoretical explanations may be offered.…”

Section: Discussionmentioning

confidence: 99%

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Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort

Cohen¹,

Margalit²,

Shochat³

et al. 2021

JIR

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Objective During the last decade, obesity has become an epidemic. As obesity is now considered a state of low-grade inflammation, the purpose of this study was to assess the prevalence of four common elements of inflammation, in individuals with increased BMI. These findings were compared to those of subjects with normal BMI. The effect of gender was also noted. Methods Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000–2014. Cross-sectional analysis was carried out on 7526 men and 3219 women. White blood cell count (WBC); platelet (PLT) count; erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed in four BMI categories: normal, overweight, obese and morbidly obese. Results Mean (SD) age of the study sample was 47.5 (9.7) and 46.7 (9.8) years for men and women, respectively. The prevalence of each inflammatory marker increased significantly when comparing abnormal to normal BMI (p<0.0001). The odds ratio (OR) of the prevalence of increased inflammatory markers was compared between subjects with overweight, obese and morbid obesity and subjects with normal BMI. This study showed that the higher the BMI, the higher the OR. For those in the morbid obesity group, the OR for the different inflammatory markers adjusting for age, diabetes mellitus hypertension and kidney function were as follows: WBC levels, 5.1 (2.9–8.7) and 4.7 (2.4–9.1) for men and women, respectively; PLT levels, 1.7 (0.3–8.5) and 2.0 (0.6–7.2) for men and women, respectively; ESR levels, 4.2 (3.2–5.4) and 4.6 (3.2–6.6) for men and women, respectively, and CRP levels, 13.4 (10.0–18.2) and 19.2 (12.9–28.6) for men and women, respectively. Conclusion Inflammatory markers are significantly higher in subjects with abnormal compared to normal BMI. This difference was found to be greater in women than in men.

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Section: Discussionmentioning

confidence: 99%

“…[6][7][8] Interestingly, recent studies have shown that bariatric surgery decreases the levels of many of the inflammatory factors. 9,10 The relationship between inflammatory markers and obesity may be influenced by gender. This is attributed to different fat disposition among men and women and to the influence of sex hormones.…”

Section: Introductionmentioning

confidence: 99%

Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort

Cohen¹,

Margalit²,

Shochat³

et al. 2021

JIR

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“…Moreover, recent studies have reported that bariatric surgery is associated with a reduction in specific adipokines including leptin, chemerin, and PAI-1, whereas Adiponectin is raised; adaptations that could be indicative of improved fat mass and function [ 56 , 57 ]. After bariatric surgery, obese subjects have an increase in Adiponectin serum levels.…”

Section: Effects Of Bariatric Surgery On Adiponectin and Orexin-amentioning

confidence: 99%

The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

Valenzano

Tartaglia

Ambrosi

et al. 2020

JCM

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The accumulation of adipose tissue represents one of the characteristics of obesity, increasing the risk of developing correlated obesity diseases such as cardiovascular disease, type 2 diabetes, cancer, and immune diseases. Visceral adipose tissue accumulation leads to chronic low inflammation inducing an imbalanced adipokine secretion. Among these adipokines, Adiponectin is an important metabolic and inflammatory mediator. It is also known that adipose tissue is influenced by Orexin-A levels, a neuropeptide produced in the lateral hypothalamus. Adiponectin and Orexin-A are strongly decreased in obesity and are associated with metabolic and inflammatory pathways. The aim of this review was to investigate the involvement of the autonomic nervous system focusing on Adiponectin and Orexin-A after bariatric surgery. After bariatric surgery, Adiponectin and Orexin-A levels are strongly increased independently of weight loss showing that hormone increases are also attributable to a rearrangement of metabolic and inflammatory mediators. The restriction of food intake and malabsorption are not sufficient to clarify the clinical effects of bariatric surgery suggesting the involvement of neuro-hormonal feedback loops and also of mediators such as Adiponectin and Orexin-A.

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“…Moreover, the circulating level of this hormone correlates with the amount of fat [ 39 ]. Weight loss after bariatric surgery decreased the level of circulating leptin [ 41 ]. It was revealed that the production of leptin by adipose tissue can induce the hepatic expression of C-reactive protein (CRP).…”

Section: Leptinmentioning

confidence: 99%

Melanoma Progression under Obesity: Focus on Adipokines

Olszańska

Pietraszek-Gremplewicz

Nowak

2021

Cancers

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Obesity is a growing problem in the world and is one of the risk factors of various cancers. Among these cancers is melanoma, which accounts for the majority of skin tumor deaths. Current studies are looking for a correlation between obesity and melanoma. They suspect that a potential cause of its development is connected to the biology of adipokines, active molecules secreted by adipose tissue. Under physiological conditions, adipokines control many processes, including lipid and glucose homeostasis, insulin sensitivity, angiogenesis, and inflammations. However, when there is an increased amount of fat in the body, their secretion is dysregulated. This article reviews the current knowledge of the effect of adipokines on melanoma growth. This work focuses on the molecular pathways by which adipose tissue secreted molecules modify the angiogenesis, migration, invasion, proliferation, and death of melanoma cells. We also discuss the role of these factors as markers of incidence, metastasis, and melanoma patient survival. Understanding the functions of adipokines will lead to knowledge of whether and how obesity promotes melanoma growth. Further studies may contribute to the innovations of therapies and the use of adipokines as predictive and/or prognostic biomarkers.

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Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

Cited by 41 publications

References 133 publications

Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort

Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort

The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

Melanoma Progression under Obesity: Focus on Adipokines

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