The efficacy of Internet‐based cognitive behavioral therapy for severely fatigued survivors of breast cancer compared with care as usual: A randomized controlled trial

Abrahams, H.J.G.; Gielissen, Marieke; Donders, Rogier; Goedendorp, Martine M.; Wouw, Agnes J. van der; Verhagen, C.A.H.H.V.M.; Knoop, Hans

doi:10.1002/cncr.30815

Cited by 115 publications

(211 citation statements)

References 32 publications

(97 reference statements)

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“…Our experience of using self‐referral recruitment in 2 RCTs8, 9 has resulted in relatively short inclusion periods, attainment of target recruitment, and high participation rates relative to our other RCTs not using self‐referral as a recruitment strategy6, 10, 11, 12 (see Table 1). This provides preliminary support for the feasibility of self‐referral in POI RCTs.…”

Section: Is Self‐referral Feasible In Poi Rcts?mentioning

confidence: 99%

One way or another: The opportunities and pitfalls of self‐referral and consecutive sampling as recruitment strategies for psycho‐oncology intervention trials

Thewes¹,

Rietjens

Berg

et al. 2018

Psycho-Oncology

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Section: Is Self‐referral Feasible In Poi Rcts?mentioning

confidence: 99%

One way or another: The opportunities and pitfalls of self‐referral and consecutive sampling as recruitment strategies for psycho‐oncology intervention trials

Thewes¹,

Rietjens

Berg

et al. 2018

Psycho-Oncology

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“…Remote delivery of CBT‐TTF is consistent with the increasing use of telemedicine in cancer care delivery and suggests a high dissemination potential for the intervention. Recent work by Abrahams et al suggests that CBT for fatigue in cancer survivors is efficacious when the intervention content is delivered via a website with minimal counselor support, further highlighting the dissemination potential of CBT for fatigue.…”

Section: Discussionmentioning

confidence: 99%

“…Cognitive behavioral therapy (CBT) has been shown to significantly reduce fatigue in disease‐free cancer survivors after treatment . CBT is recommended as an evidence‐based treatment for cancer‐related fatigue by the American Society of Clinical Oncology and the National Comprehensive Cancer Network .…”

Section: Introductionmentioning

confidence: 99%

Internet‐assisted cognitive behavioral intervention for targeted therapy–related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial

Jim

Hyland

Nelson

et al. 2019

Cancer

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Background Fatigue is a common and disabling side effect of targeted therapies such as tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukemia (CML). The goal of the current study was to conduct a pilot randomized trial of the first cognitive behavioral intervention developed for fatigue due to targeted therapy. Methods Patients with CML treated with a TKI who were reporting moderate to severe fatigue were recruited and randomized 2:1 to cognitive behavioral therapy for targeted therapy–related fatigue (CBT‐TTF) delivered via FaceTime for the iPad or to a waitlist control (WLC) group. The outcomes were acceptability, feasibility, and preliminary efficacy for fatigue (Functional Assessment of Chronic Illness Therapy–Fatigue; primary outcome) and quality of life (Functional Assessment of Cancer Therapy–General; secondary outcome). Participants were assessed before randomization and after treatment (ie, approximately 18 weeks later). Results A total of 44 patients (mean age, 55 years; 48% female) were assigned to CBT‐TTF (n = 29) or WLC (n = 15). The study participation rate was 59%. Among the patients assigned to CBT‐TTF, 79% completed the intervention. Intent‐to‐treat analyses indicated that patients assigned to CBT‐TTF demonstrated greater improvements in fatigue (d = 1.06; P < .001) and overall quality of life (d = 1.15; P = .005) than those assigned to WLC. More patients randomized to CBT‐TTF than WLC demonstrated clinically significant improvements in fatigue (85% vs 29%) and quality of life (88% vs 54%; P values ≤ .016). Conclusions CBT‐TTF displays preliminary efficacy in improving fatigue and quality of life among fatigued patients with CML treated with TKIs. The findings suggest that a larger randomized study is warranted.

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“…Such online interventions, with a therapist in the background, are effective in reducing fatigue [1, 3] and show potential for unguided interventions.…”

Section: Current Carementioning

confidence: 99%

Untire: an all-embracing self-management eHealth program to cope with cancer-related fatigue

Kuiper¹,

Wolvers²,

Vonk³

et al. 2018

ecancer

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Cancer-related fatigue (CRF) is a frequent and invalidating problem in (former) cancer patients. If there are no medical causes, relief of fatigue can be attained by means of non-pharmacological interventions. Guidelines prescribe a multimodal approach with a focus on mental processes, physical activity and sleep. Online interventions have been shown to be effective in reducing CRF. These results inspired the creation of an all-embracing app on the various behavioural and physical activity modification themes that are recommended in oncological guidelines.This basis for the ‘Untire’ app is the Daily Program, consisting of 4 components.In 2018, the ‘Untire’ app will be launched in several languages throughout the European Union and some other countries outside Europe, such as the USA. Its effectiveness will be studied by means of a randomized controlled trial.

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The efficacy of Internet‐based cognitive behavioral therapy for severely fatigued survivors of breast cancer compared with care as usual: A randomized controlled trial

Abstract: ICBT appears to be effective in reducing severe fatigue and related symptoms and meets the current need for easy accessible and more efficient evidence-based treatment options for severely fatigued survivors of breast cancer. Cancer 2017;123:3825-34. © 2017 American Cancer Society.

Cited by 115 publications

References 32 publications

One way or another: The opportunities and pitfalls of self‐referral and consecutive sampling as recruitment strategies for psycho‐oncology intervention trials

One way or another: The opportunities and pitfalls of self‐referral and consecutive sampling as recruitment strategies for psycho‐oncology intervention trials

Internet‐assisted cognitive behavioral intervention for targeted therapy–related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial

Untire: an all-embracing self-management eHealth program to cope with cancer-related fatigue

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