Internet‐assisted cognitive behavioral intervention for targeted therapy–related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial

Jim, Heather; Hyland, Kelly A.; Nelson, Ashley M.; Pinilla‐Ibarz, Javier; Sweet, Kendra; Gielissen, Marieke; Bulls, Hailey W.; Hoogland, Aasha I.; Jacobsen, Paul B.; Knoop, Hans

doi:10.1002/cncr.32521

Cited by 27 publications

(27 citation statements)

References 22 publications

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“…Twenty‐three studies (Abrahams et al, 2017; Bantum et al, 2014; Boele et al, 2018; Foster et al, 2016; Freeman et al, 2015; Huberty et al, 2019; Jim et al, 2020; Kearney et al, 2009; Kubo et al, 2019; Ligibel et al, 2012; Ream et al, 2015; Ritterband et al, 2012; Shi et al, 2015; Smith et al, 2019; Somers et al, 2018; Spahrkas et al, 2020; Steel et al, 2016; Vallerand et al, 2018; van den Berg et al, 2015; Willems et al, 2017; Yun et al, 2012; Zachariae et al, 2018; Zhou et al, 2020) evaluated the effectiveness of eHealth interventions on CRF. The pooled result showed a small effect of eHealth interventions on CRF, and the improvement was not statistically significant (SMD = −0.16, 95% CI: −0.33 to 0.01, p = 0.07; I 2 = 79%, p < 0.00001) (Figure S8).…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of eHealth interventions for cancer‐related pain, fatigue, and sleep disorders in cancer survivors: A systematic review and meta‐analysis of randomized controlled trials

Zhu

Liu

et al. 2021

J of Nursing Scholarship

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According to the International Agency for Research on Cancer (IARC), the global cancer burden is estimated to rise to 28.4 million new cancer cases in 2040, which is a 47% increase compared with 19.3 million in 2020. Fortunately, cancer survivors' life expectancy has improved significantly due to advances in prevention, diagnosis, and treatment (Harris et al., 2018). Globally, the total number of people who are alive within 5 years of a cancer diagnosis is estimated to be 50.6 million (IARC).Cancer survivors usually suffer from a variety of cancer-related symptoms. Previous studies have demonstrated that cancer-related

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Section: Resultsmentioning

confidence: 99%

Effectiveness of eHealth interventions for cancer‐related pain, fatigue, and sleep disorders in cancer survivors: A systematic review and meta‐analysis of randomized controlled trials

Zhu

Liu

et al. 2021

J of Nursing Scholarship

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“…The online delivery of CBT has several advantages over face-to-face delivery: (1) it ensures therapy continuation despite preventive public health measures, (2) the intervention is easily accessible, (3) it reduces patient burden as it saves time and costs to travel to the treatment centre and (4) for therapists, less time investment is needed which increases treatment capacity [ 27 , 29 ]. It has been shown that CBT interventions for severe fatigue can be successfully implemented in other countries and health care systems [ 88 , 89 ]. These advantages would ensure that the intervention can be readily implemented, reaching a large group of patients.…”

Section: Discussionmentioning

confidence: 99%

A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocol

Kuut

Müller

Aldenkamp

et al. 2021

Trials

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Background Coronavirus disease 2019 (COVID-19) results in debilitating long-term symptoms, often referred to as Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), in a substantial subgroup of patients. One of the most prevalent symptoms following COVID-19 is severe fatigue. Prompt delivery of cognitive behavioural therapy (CBT), an evidence-based treatment that has shown benefit in reducing severe fatigue in other conditions, may reduce post-COVID-19 fatigue. Based on an existing CBT protocol, a blended intervention of 17 weeks, Fit after COVID, was developed to treat severe fatigue after the acute phase of infection with SARS-CoV-2. Method The ReCOVer study is a multicentre 2-arm randomised controlled trial (RCT) to test the efficacy of Fit after COVID on severe post-infectious fatigue. Participants are eligible if they report severe fatigue 3 up to and including 12 months following COVID-19. One hundred and fourteen participants will be randomised to either Fit after COVID or care as usual (ratio 1:1). The primary outcome, the fatigue severity subscale of the Checklist Individual Strength (CIS-fatigue), is assessed in both groups before randomisation (T0), directly post CBT or following care as usual (T1), and at follow-up 6 months after the second assessment (T2). In addition, a long-term follow-up (T3), 12 months after the second assessment, is performed in the CBT group only. The primary objective is to investigate whether CBT will lead to a significantly lower mean fatigue severity score measured with the CIS-fatigue across the first two follow-up assessments (T1 and T2) as compared to care as usual. Secondary objectives are to determine the proportion of participants no longer being severely fatigued (operationalised in different ways) at T1 and T2 and to investigate changes in physical and social functioning, in the number and severity of somatic symptoms and in problems concentrating across T1 and T2. Discussion This is the first trial testing a cognitive behavioural intervention targeting severe fatigue after COVID-19. If Fit after COVID is effective in reducing fatigue severity following COVID-19, this intervention could contribute to alleviating the long-term health consequences of COVID-19 by relieving one of its most prevalent and distressing long-term symptoms. Trial registration Netherlands Trial Register NL8947. Registered on 14 October 2020.

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“…For metastatic GIST patients in a stable phase who are being treated with TKI inhibitors, such an app-based tool might be of interest if psychosocial face-to-face intervention is not feasible. In addition, two studies in chronic myeloid leukemia patients on TKIs showed that cognitive behavioural therapy improved qualitative level of functioning and coping with treatment-related fatigue [ 43 , 44 ]. The translational value for GIST patients warrants further studies.…”

Section: Discussionmentioning

confidence: 99%

Striving towards Normality in Daily Life: A Qualitative Study of Patients Living with Metastatic Gastrointestinal Stromal Tumour in Long-Term Clinical Remission

Fauske

Hompland

Lorem

et al. 2020

Sarcoma

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Background. This study explored how patients with metastatic gastrointestinal stromal tumour (GIST) experience the psychosocial challenges associated with their disease and its treatment, as well as how that experience influenced their practical, relational, vocational, and existential life. Methods. This qualitative study has an explorative design and applied a phenomenological and hermeneutical approach. We conducted in-depth, semistructured interviews with 20 patients with metastatic GIST in long-term clinical remission. The gathered data were interpreted using a thematic analysis. Results. Living with metastatic GIST, as well as the side effects of the required medication, led to changes that limited the participants’ daily life. They expressed how tiredness, impaired memory, and physical challenges were among the detrimental impacts of the disease on their family life, vocational life, social life, and leisure time. Adjustments were necessary to ensure they had sufficient energy to cope with the practical and relational aspects of everyday life. Feelings of uncertainty stemming from drug resistance, disease progression, and the possibility of early death were also experienced as challenging. Half the participants stated that it was difficult to keep negative mental health issues at bay, and all of them considered the time spent waiting for their scheduled follow-up scan to be burdensome. Conclusions. It is important to focus increased attention on how the daily practical and psychosocial life of patients with chronic cancer, including metastatic GIST, is affected by their disease. Doing so might provide health-care workers with clues regarding how best to guide and support such patients throughout their emotional journey and, therefore, to improve their quality of life. As new medical treatments can also prolong survival and induce long-term clinical remission in relation to several other forms of metastatic cancer, the findings concerning GIST reported in this study might have widespread implications.

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Internet‐assisted cognitive behavioral intervention for targeted therapy–related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial

Cited by 27 publications

References 22 publications

Effectiveness of eHealth interventions for cancer‐related pain, fatigue, and sleep disorders in cancer survivors: A systematic review and meta‐analysis of randomized controlled trials

Effectiveness of eHealth interventions for cancer‐related pain, fatigue, and sleep disorders in cancer survivors: A systematic review and meta‐analysis of randomized controlled trials

A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocol

Striving towards Normality in Daily Life: A Qualitative Study of Patients Living with Metastatic Gastrointestinal Stromal Tumour in Long-Term Clinical Remission

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