Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing

Alavarse, Alex Carvalho; Silva, Fernanda Waitman de Oliveira; Colque, Jandir Telleria; Silva, Viviam Moura da; Prieto, Tatiane; Venâncio, Everaldo C.; Bonvent, Jean-Jacques

doi:10.1016/j.msec.2017.03.199

Cited by 269 publications

(135 citation statements)

References 86 publications

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“…The main appeal of electrospinning, aside from the simplicity of the equipment required, is the tunability of the method, allowing the generation of fibers from as small as tens of nanometers to several micrometers with a wide array of morphologies. In biomedical applications, recent work has utilized electrospun polycaprolactone/gelatin composite materials for guided bone regeneration, drug delivery in soft tissue, and wound dressings based on biodegradable polymers such as polyetherimide, polylactic acid, and others . In electrochemistry, electrospun materials are being employed in a range of devices, such as lithium‐ion battery separators .…”

Section: Introductionmentioning

confidence: 99%

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Kok

Jervis

Brett

et al. 2018

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Electrospun custom made flow battery electrodes are imaged in 3D using X-ray computed tomography. A variety of computational methods and simulations are applied to the images to determine properties including the porosity, fiber size, and pore size distributions as well as the material permeability and flow distributions. The simulations are performed on materials before and after carbonization to determine the effect it has in the internal microstructure and material properties. It is found that the deposited fiber size is constantly changing throughout the electrospinning process. The results also show that the surfaces of the fibrous material are the most severely altered during carbonization and that the rest of the material remained intact. Pressure driven flow is modeled using the lattice Boltzmann method and excellent agreement with experimental results is found. The simulations coupled with the material analysis also demonstrate the highly heterogeneous nature of the flow. Most of the flow is concentrated to regions with high porosity while regions with low porosity shield other pores and starve them of flow. The importance of imaging these materials in 3D is highlighted throughout.

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Section: Introductionmentioning

confidence: 99%

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Kok

Jervis

Brett

et al. 2018

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“…However, the inhibition zone was recorded using GG+TiO 2 -NRs films at 10±0.35 mm, 12±0.06 mm, 11±0.06 mm, and 10±0.38 mm against S. aureus, Strep., E. coli, and P. aeruginosa which is comparable with penicillin control sample ( Table 1). Good antibacterial activity by GG+TiO 2 -NRs films was due to the presence of TiO 2 nanostructures which is promoted the ROS (reactive oxygen species) generation, release of metal ion, malfunction of membrane system, and internalization of nanoparticles 23 . With the present of UV light, the TiO 2 -NRs that were incorporated into GG films produced ROS species (eg.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Characterization of Antibacterial Titanium Dioxide Nanorods Incorporating Gellan Gum Films

Razali¹,

Ismail²,

Amin³

2019

J Pure Appl Microbiol

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The aim of this work was to develop bionanocomposite films based biopolymer GG and TiO 2 -NRs for active food packaging. The TiO 2 -NRs were incorporated as antimicrobials agent into GG via solvent casting method. The films appearance was have 94 % of transparency. SEM micrographs indicate that the TiO 2 -NRs were successfully incorporated and attached to the surface of developed GG films. FTIR results revealed the interaction between TiO 2 -NRs and hydroxyl group of GG polymer. XRD results showed the crystalline peaks of TiO 2 -NRs and amorphous peaks of GG+TiO 2 -NRs films. The thermal stability of GG films were increasing by incorporation of TiO 2 -NRs materials. The GG+TiO 2 -NRs films showed good antibacterial activity against Gram-positive (Staphylococcus aureus (S. aureus) and Streptococcus (strep.)) and Gram-negative (Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa)) and potentially used as antibacterial packaging films.

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“…Both sides of the samples were sterilized under UV light for 30 min. To extract potential cytotoxic residues, the sterile samples were incubated with MSCs culture medium at 37 °C for 24 h with an extraction ratio of 1 cm 2 mL −1 . After the incubation period, the hydrogel samples were removed and the incubated media with samples were diluted twofold in fresh MSCs culture medium.…”

Section: Methodsmentioning

confidence: 99%

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Bal‐Öztürk

Karal-Yılmaz

Akgüner

et al. 2019

J of Applied Polymer Sci

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In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze‐drying technique. Genipin was used as a crosslinker. The prepared chitosan‐based sponges were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy—energy‐dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge‐like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like‐nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.

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Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing

Cited by 269 publications

References 86 publications

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Fabrication and Characterization of Antibacterial Titanium Dioxide Nanorods Incorporating Gellan Gum Films

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

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