Evaluation of Corelation between  Salivary Calcium, Alkaline Phosphatase  and Osteoporosis- A Prospective,  Comparative and Observational Study

Saha, Mainak Kanti

doi:10.7860/jcdr/2017/24960.9583

Cited by 11 publications

(12 citation statements)

References 10 publications

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“…ALP is found in cells of the periodontium, such as fibroblasts, neutrophils, and osteoblasts, and is released during their migration to the site of infection (Safkan-Seppala and Ainamo, 1992). In addition, in edentulous, osteoporotic, or osteopenic individuals, the level of salivary ALP was significantly higher when compared to the control group, suggesting that this component may be an indicator of bone metabolism disorders (Saha et al, 2017). In the present study, salivary ALP was associated with pulp stones.…”

Section: Discussionsupporting

confidence: 52%

“…Salivary Ca was not associated with pulp stones. Previously, higher salivary levels of Ca were observed in patients with renal disease (Alpdemir et al, 2018), diabetes (Ladgotra et al, 2016), and osteoporosis and osteopenia (Saha et al, 2017). Caries-free children may also demonstrate increased salivary Ca levels (Pandey et al, 2015).…”

Section: Discussionmentioning

confidence: 94%

“…Such alterations have also been observed in the most prevalent oral diseases, for example, increased total protein (TPT) levels in the presence of dental caries (Pandey et al, 2015) and periodontal disease (Shaila et al, 2013). In the past decades, numerous studies have described, standardized, and validated analyses of salivary organic and inorganic components (Teixeira et al, 2012;Malathi et al, 2013;Shaila et al, 2013;Pandey et al, 2015;Buche et al, 2017;Khozeimeh et al, 2017;Saha et al, 2017;Alpdemir et al, 2018;De et al, 2018;Jeyasree et al, 2018;Riis et al, 2018;Alshahrani et al, 2019). Owing to the detection of serum constituents, saliva has also been used as a tool for diagnosis, monitoring, and management of patients with both oral and systemic diseases (Malamud, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Gabardo

Kublitski

Sette

et al. 2020

Front. Cell Dev. Biol.

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The aim of this study was to analyze the saliva of patients with pulp stones, with sialometric and sialochemical tests. Eighty individuals, aged between18 and 65 years, of both sexes, were investigated. Patients were included in the pulp stone group when radiographic examination was suggestive of pulp stones in at least one permanent tooth, whereas those without this alteration were considered controls. Saliva was collected by stimulation, followed by salivary flowrate (SFR) and pH analysis tests. The organic components, such as urea (URE), glucose (GLU), total proteins (TPTs), alkaline phosphatase, creatinine (CRE), salivary amylase (SAM), and uric acid (URA), and the inorganic components, such as calcium, iron, and phosphorus, were evaluated by colorimetric techniques in an ultraviolet-visible (UV-vis) spectrophotometer. Differences among pulp stones and control groups were compared using Student's t-test, with a significance level of p < 0.05. In both groups prevailed the female. Statistically significant differences between groups were observed for pH (p = 0.027), SFR (p = 0.002), alkaline phosphatase (p = 0.008), and URA (p = 0.005). None of the inorganic components showed significant difference (p > 0.05). In the analyses stratified by sex, difference between groups was observed for pH (p = 0.007) and URA (p = 0.003) in women. In conclusion, sialometric and sialochemical alterations occurred in patients with pulp stones, with significantly higher levels of pH, SFR, alkaline phosphatase, and URA.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Gabardo

Kublitski

Sette

et al. 2020

Front. Cell Dev. Biol.

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“…So, evaluating alkaline phosphatase and other bone turn over markers may help in determining loss of bone mineral density in postmenopausal females 19-21. In another interesting study the researcher found that salivary calcium and alkaline phosphatase are also raised in osteopenic and osteoporotic patients and thus can be used for the diagnosis of underlying bone disorders22 It is important to note that multiple factors affects bone density 23,24. These effects influence bone through complex pathways.…”

Section: Discussionmentioning

confidence: 99%

Alkaline phosphatase is a predictor of Bone Mineral Density in postmenopausal females

Tariq¹,

Tariq

Lone³

et al. 2019

Pak J Med Sci

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Objectives: The study was planned to determine whether serum calcium, phosphate and alkaline phosphatase (ALP) are predictors of bone mineral density (BMD) in postmenopausal non-osteoporotic, osteopenic, and osteoporotic females. Methods: In this cross sectional study, conducted at Shaikh Zayed Hospital, Lahore in the year 2014-2015, postmenopausal females between 50-70 years of age were taken and divided into three groups non-osteoporotic (n=52), osteopenic (n=69) and osteoporotic (n=47). Serum ALP, phosphate and calcium were used in a stepwise multiple regression analysis to predict T-score in these groups. Results: In normal postmenopausal females, the prediction model was statistically significant, F(2, 41) = 6.041, p < 0.05 and showed a T-score variance of 22%. T-score was primarily predicted by higher levels of phosphate and calcium. In postmenopausal osteopenic females, T-score was only predicted by lower levels of ALP. The model was statistically significant, F(1, 59) = 4.995, p < 0.05, and accounted for approximately 7% of the variance of T-score. In postmenopausal osteoporotic females, the prediction model contained no predictors. Conclusion: Our study suggested that calcium and phosphate are the strongest predictors of T-score in postmenopausal normal females, while in postmenopausal osteopenic females ALP was the strongest predictor of T-score. Elevated serum ALP levels may help in determining loss of BMD in postmenopausal females. doi: https://doi.org/10.12669/pjms.35.3.188 How to cite this:Tariq S, Tariq S, Lone KP, Khaliq S. Alkaline phosphatase is a predictor of Bone Mineral Density in postmenopausal females. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.188 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…17 Regarding salivary calcium levels, the present study found a statistically significant greater amount in low BMD patients than in those without bone mineral changes, thus corroborating the findings of other studies that used similar samples, in which salivary calcium levels proved to be significantly higher in patients with bone mineral changes when compared to controls. 18,19,20 Some studies have tried to establish methods for the diagnosis or prognosis of oral diseases using salivary analysis. 8 Calcium is one of the most important salivary electrolytes because of its effective role in bone structures; it is also the most important ion in the composition of this structure; and it plays a significant role in bone regeneration, which is directly related to osteoporosis, a change that may occur as a consequence of reduced absorption of this electrolyte, which may occur in either the bone or saliva.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of oral and salivary parameters in patients with and without loss of bone mass

et al. 2018

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Osteoporosis is an insidious and increasingly prevalent disease that can cause fractures and affect patients' quality of life. The current study comparatively evaluates patients with and without loss of bone mass in terms of salivary calcium, viscosity, and pH. A controlled cross-sectional study was conducted in two groups of 32 postmenopausal women subjected to a bone densitometry scan and later referred for dental management at the Federal University of Minas Gerais, Brazil. The patients were assigned to two groups: Group 1 - patients with low bone mineral density (BMD) and Group 2 - patients without bone mineral changes. The following salivary parameters were evaluated: calcium concentration, flow rate, viscosity, pH, and average total protein. An oral examination was performed for assessment of DMFT variables and tongue coating. Data were analyzed using descriptive and inferential statistics, adopting a p-value < 0.05. The patients' mean age was 60 years (± 7.35). Salivary flow, pH, and viscosity were similar among the groups. Average total protein was 14.8 mg/mL and 19.0 mg/mL in Groups 1 and 2, respectively. Tongue coating and salivary calcium levels were significantly higher in Group 1 (p < 0.001). Salivary calcium is an important screening tool and may eventually be used for the diagnosis of bone mineral changes.

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Evaluation of Corelation between Salivary Calcium, Alkaline Phosphatase and Osteoporosis- A Prospective, Comparative and Observational Study

Abstract: Salivary calcium and alkaline phosphatase are increased significantly in case of osteoporosis and osteopenia. Hence, screening of salivary samples of patients may be an effective indicator for the detection of underlying disorders of bone metabolism.

Cited by 11 publications

References 10 publications

Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Sialometric and Sialochemical Analysis in Individuals With Pulp Stones

Alkaline phosphatase is a predictor of Bone Mineral Density in postmenopausal females

Comparative study of oral and salivary parameters in patients with and without loss of bone mass

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