Paracoccidioidomycosis (PCM) is a rare fungal infection in the world, but endemic and acquired exclusively in Latin America, with the highest prevalence in South America and Brazil, particularly. Changes in oral cavity are common and constitute the first clinical manifestation in many patients. The aim of this study was to describe the prevalence of oral PCM and analyse the profile of the disease and patients. Retrospective research, consisting of information present in the medical records in the period 1998-2015, whose histopathological diagnosis was oral PCM. Fifty-five oral PCM cases were confirmed. Of these patients, 90.9% were males and 9.1% were females. The average age was 49.66 years and the most reported occupation was rural workers. The painful symptomatology was present in 61.82% of patients. Erythematous lesions were predominant in 73% of them. In single lesions (22 cases), the most common locations were jugal mucosa and tongue. In multiple involvement (30 cases), the most affected regions were lips, jugal mucosa and alveolar ridge. Epidemiology of PCM, was similar to several other studies, especially in Brazil. This is the most important fungal infection in Latin America and the recognition of oral lesions is extremely important, as is often the first and in many cases the only manifestation of the disease.

Aim: To determine the prevalence of radiationinduced oral mucositis (OM) and associated factors. Patients and Methods: A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)]. Results: Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06). Conclusion: Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer.Oral mucositis (OM) is one of the most significant and common complications of radio/chemotherapy for the treatment of head and neck cancer (1-3). The pathogenesis of OM is complex and related to xerostomia, which is a consequence of the impairment of the salivary glands caused by radiation. OM may occur during or after treatment, the debilitating adverse effects of which include severe pain as well as difficulties in eating and performing oral hygiene, thereby compromising quality of life and potentially leading to suspension of cancer treatment, which increases the risk of death (4, 5).Data on the prevalence of radiation-induced OM in patients submitted to treatment for head and neck cancer are scarce in the literature and reveal considerable variation (6, 7). Recent studies have focused more on the different methods of cancer treatment rather than the causes of OM and associated factors (8,9).The oral regions most affected by OM are the floor of the mouth, lateral edge of the tongue, buccal mucosa and soft palate (10). Erythema is the initial manifestation, followed by the development of desquamative white plaques, which ulcerate, causing considerable pain. Poor oral hygiene and an absence of clinical follow-up before and during radiotherapy may aggravate the problem (8).An in-depth investigation of OM would provide information for better clinical management of this complication, contributing to its prevention and improving the quality of life of patients (9, 10). Thus, the aim of the present study was to investigate the prevalence of radiationinduced OM and report its associated factors.

Inherited factor VII (FVII) deficiency is the most common among the rare bleeding disorders. It is transmitted as an autosomal recessive inheritance, due to mutations in the FVII gene (F7). Molecular studies of FVII deficiency are rare in non-Caucasian populations. The aim of the study was to evaluate the molecular basis behind low levels of FVII activity (FVII:C) levels in a cohort of Brazilian patients. A total of 34 patients with low FVII levels were clinically evaluated and submitted to laboratory tests, among these, prothrombin time and FVII:C, with different thromboplastins. All exons and intron/exon boundaries of F7 were amplified and sequenced. A total of 14 genetic alterations were identified, of which six were described previously, c.1091G>A, c.1151C>T, c.-323_-313insCCTATATCCT, c.285G>A, c.525C>T, c.1238G>A and eight (54.0%) and eight were new, c.128G>A, c.252C>T, c.348G>A, c.417G>A, c.426G>A, c.745_747delGTG, c.843G>A and c.805+52C>T. In addition to the mutation c.1091G>A, known as FVII Padua, the mutation c.1151C>T also presented discrepant FVII:C levels when tested with human and rabbit brain thromboplastin. There was no association between phenotype and genotype. Most of the identified genetic alterations found were polymorphisms. Low levels of FVII:C in this population were mostly related to polymorphisms in F7 and associated with a mild clinical phenotype. Mutation c.1151C>T was associated with discrepant levels of FVII:C using different thromboplastins, such as reported with FVII Padua.

RESUMOObjetivo: Analisar o perfil das internações de crianças e adolescentes com fraturas do crânio e ossos da face na região Nordeste, Brasil, no período de 2008 a 2010. Material e Métodos: Utilizou-se uma abordagem indutiva com procedimento comparativo-descritivo e técnica de documentação indireta. Os dados foram obtidos mediante consulta aos sítios do DATASUS para os anos de 2008 a 2010, nas faixas etárias de 0 a 19 anos, considerando as informações disponíveis para cada estado da região nordeste, sendo analisados descritivamente por meio de frequências absolutas e percentuais. Resultados: No ano de 2008, obteve-se um valor total de 1.418 notificações, com maior prevalência do gênero masculino (77,36%) e faixa etária mais acometida a de 15 a 19 anos, sendo a Bahia o estado com número mais expressivo de internações (n=274; 17,42%). No ano de 2010, foram registradas 1.352 internações, evidenciando-se maior envolvimento do gênero masculino (79,66%) e da faixa etária de 15 a 19 anos, constatando-se que o Ceará apresentou valores mais elevados de internação (n=301; 22,26%). Conclusão: Houve uma maior ocorrência de fraturas em indivíduos do sexo masculino e a faixa etária mais acometida foi a de 15 a 19 anos. Os estados da Bahia e do Ceará apresentaram o maior número de internações, já os estados de Sergipe e do Maranhão foram os menos acometidos no período estudado. DESCRITORESEpidemiologia. Fraturas Maxilomandibulares. Fraturas Cranianas.

Introduction: Treatments with dental surgery seek to displace tooth to the correct position within the dental arch. Objective:To report a clinical case that took advantage of an unerupted third molar. Case history: A male patient, 18 years of age, was referred by his dentist to evaluate the third molars. The clinical exam revealed no visible lower third molars. The computed tomography (CT) exam showed the presence of a supernumerary tooth in the region of the mandibular ramus, on the left side, and impaction of the third molar, which was causing root resorption on the second molar, thus making it impossible to remain in the buccal cavity. The preferred option, therefore, was to remove both second molar and the supernumerary tooth, in addition to attaching a device to the third molar during surgery for further traction. Results: After 12 months, the third molar reached the proper position. Conclusion: When a mandibular second permanent molar shows an atypical root resorption, an impacted third molar can effectively substitute the tooth by using an appropriate orthodontic-surgical approach.

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Background:Although oral candidiasis (OC) is a very common fungal infection of oral cavity, clinical features of affected patients and their demographic profile are not well documented.Objective:The objective of the study was to assess the demographic profile of patients diagnosed with OC and its clinical features in an import Brazilian center of oral and maxillofacial pathology.Materials and Methods:A retrospective study consisted of 276 patients diagnosed with OC by cytopathology Periodic Acid-Schiff (PAS) staining, during the period of 20 years. The variables related to patients were gender, age and skin color. Regarding infection, the data collected were location, color, symptoms, early manifestation, or recurrent and associated factors.Results:Male and female were equally affected, and the median age was 43 years. The majority of lesions were of primitive origin, asymptomatic and affecting only one site of oral cavity. The most affected site was the palate followed by tongue. More than a half of the patients (56.2%) had red lesions. The main associated factors related were the use of removable prostheses, bone marrow transplantation and AIDS.Conclusions:OC affects predominantly adults and elderly, without difference between sex and skin color. Although clinical findings are crucial, cytopathology tests are important complementary examinations to reach a definitive diagnosis. PAS staining seems to be more used in cases of erythematous candidiasis since white lesions are easier to diagnose clinically.

a b s t r a c tAdenomatoid odontogenic tumor (AOT) is a rare odontogenic tumor with limited growth and usually associated with an unerupted permanent tooth. It is a benign lesion, with a low rate of recurrence after surgical treatment. This is a case report of an 11-year-old female with an asymptomatic tumor growth on the maxilla and palatal displacement of the lateral incisor. A unilocular lesion surrounding the coronal impacted right upper canine and the displacement of premolars were observed radiographically. After incisional biopsy, the tumor was diagnosed as AOT. The enucleation of the lesion and the removal of the impacted canine was performed. Four months later, the patient had not shown any signs of recurrence and was referred for orthodontic treatment. New surgical procedure was performed to remove the gums that covered the premolars to promote their eruption. Five years later, the premolars are in position in the dental arch and there are no signs of recurrence of the lesion. (Rev Port Estomatol Med Dent Cir Maxilofac. 2017;58(2):126-131) © 2017 Sociedade Portuguesa de Estomatologia e Medicina Dentária. Published by SPEMD. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). rev port estomatol med dent cir maxilofac. 2017;58(2): 126-131 r e s u m o Tratamento cirúrgico de Tumor Odontogénico Adenomatóide: Acompanhamento de 5 anos Palavras-chave: Tumor odontogênico adenomatóide Dente impactado Tumores odontogênicos Cirurgia oral O tumor odontogênico adenomatóide (TOA) é um tumor raro com crescimento limitado egeralmente associado a um dente permanente não erupcionado. É uma lesão benigna, com baixa taxa de recorrência após tratamento cirúrgico. Relato de caso de uma menina de 11 anos de idade com crescimento tumoral assintomático na maxila e deslocamento palatino do incisivo lateral. Radiograficamente, foi observada uma lesão unilocular em torno da coroa do canino superior direito impactado e deslocamento dos pré-molares. Após a biópsia inci-sional, o tumor foi diagnosticado como TOA. A enucleação da lesão e do canino impactado foi realizada. Quatro meses depois, o paciente não apresentou sinais de recorrência e foi encaminhado para tratamento ortodôntico. Um novo procedimento cirúrgico foi realizado para remover a gengiva que cobria os pré-molares para promover sua erupção. Após cinco anos, os pré-molares encontram-se em posição no arco dentário e não existem sinais de recorrência da lesão. (Rev Port Estomatol Med Dent Cir Maxilofac. 2017;58(2):126-131)