Oral candidiasis: A retrospective study of 276 Brazilian patients

Meira, Henrique Côrtes; Oliveira, Bruna Mascarenhas De; Pereira, Igor Figueiredo; Naves, Marcelo Drummond; Mesquita, Ricardo Alves; Santos, Vagner Rodrigues

doi:10.4103/jomfp.jomfp_77_16

Cited by 8 publications

(3 citation statements)

References 18 publications

(20 reference statements)

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“…to mount pathogenicity that consequently trails to candidiasis progressively (Akpan and Morgan, 2002;Millsop and Fazel, 2016). Among various forms of candidiasis, oral candidiasis is depicted to be the most common human fungal infection, specifically in the early and later life (Abu-Elteen and Abu-Alteen, 1998;Meira et al, 2017;Rath, 2017). C. albicans is the predominantly encountered species in oral candidiasis patients, irrespective of the denture status (Muadcheingka and Tantivitayakul, 2015).…”

Section: Introductionmentioning

confidence: 99%

Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans

Priya

Pandian

2020

Front. Microbiol.

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Candida albicans is the primary etiological agent associated with the pathogenesis of candidiasis. Unrestricted growth of C. albicans in the oral cavity may lead to oral candidiasis, which can progress to systemic infections in worst scenarios. Biofilm of C. albicans encompasses yeast and hyphal forms, where hyphal formation and yeast to hyphal morphological transitions are contemplated as the key virulence elements. Current clinical repercussions necessitate the identification of therapeutic agent that can limit the biofilm formation and escalating the susceptibility of C. albicans to immune system and conventional antifungals. In the present study, a plant-derived alkaloid molecule, piperine, was investigated for the antibiofilm and antihyphal activities against C. albicans. Piperine demonstrated a concentration-dependent antibiofilm activity without exerting negative impact on growth and metabolic activity. Inhibition in the hyphal development was witnessed through confocal laser-scanning microscopy and scanning electron microscopy. Interestingly, piperine displayed a tremendous potential to inhibit the virulence-associated colony morphologies, such as filamentation and wrinkling. Furthermore, piperine regulated morphological transitions between yeast and hyphal forms by inhibiting hyphal extension and swapping hyphal phase to yeast forms yet under filamentation-inducing circumstances. Remarkably, piperinechallenged C. albicans exhibited low potential for spontaneous antibiofilm resistance development. In addition, piperine effectively reduced in vivo colonization and prolonged survival of C. albicans-infected Caenorhabditis elegans, thereby expounding the distinct antivirulent potential. Transcriptomic analysis revealed piperine significantly downregulating the expression of several biofilm related and hyphal-specific genes (ALS3, HWP1, EFG1, CPH1, etc.). Furthermore, no acute toxicity was observed in the HBECs and nematodes exposed to piperine. Altogether, results from this study reveals the potential of piperine to inhibit biofilm and hyphal morphogenesis, and its in vivo efficacy and innocuous nature to HBECs suggests that piperine may be considered as a potential candidate for the treatment of biofilm-associated C. albicans infection, especially for oral candidiasis.

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Section: Introductionmentioning

confidence: 99%

Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans

Priya

Pandian

2020

Front. Microbiol.

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“…Meira et al . [ 15 ] reported involvement of palate in 52.9% and tongue in 43.4% patients. Roy et al .…”

Section: Discussionmentioning

confidence: 99%

Oral mucosal lesions - A study of 369 cases

Jain

Mahajan

Rathi

et al. 2023

Indian Dermatol Online J

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Background: Diagnosing and treating oral cavity lesions is a challenging task for most of the clinicians due to similar symptoms and clinical appearances. Frequently, histopathology and immunohistochemistry aid in making the diagnosis. Objectives: The objectives were to describe the clinical features, and histopathological features and systemic association in patients with oral mucosal lesions (OML). Materials and Methods: A cross-sectional descriptive study was undertaken at a tertiary care centre in patients with OML. A total of 369 cases with OML were included in the study. Results: Males constituted 61.78% of the cases. History of habits such as tobacco, gutka chewing, smoking, and alcohol was given by 32.25%, 29.81%, 26.56%, and 11.38% of cases, respectively. Common symptoms were soreness, burning sensation, oral pain and ulcers. Both oral and cutaneous involvement was seen in 17.89% of cases. Oral lichen planus (oral LP) constituted largest group of patients (21.96%) wherein reticulate type was the most frequent type and buccal mucosa was the commonest site. Oral carcinomas constituted 20.33% of cases followed by infective etiology (11.92%), vesiculobullous group of diseases (10.30%), aphthous stomatitis (8.94%), premalignant lesions (7.05%) such as leukoplakia (3.80%) and submucous fibrosis (2.44%). Histopathology was done in 209 cases. Clinico-histopathological correlation was seen in oral LP (90.27%), oral pemphigus (82.35%), and malignancies (98.66%). Conclusion: Oral LP formed the largest group of cases followed by Oral squamous cell carcinoma (SCC). Several rare conditions, such as Melkersson–Rosenthal syndrome and blue rubber bleb nevus syndrome were also a part of the study. Thorough clinical and histopathological examination in this diverse group of diseases clinches the diagnosis.

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“…Besides the role of Candida species, other age‐related local and systemic factors, including oral mucosal erosion, suppressed immunity, decreased salivary flow rate, and insufficient vitamin intake, play contributing parts in the development of candidiasis. In fact, oral candidiasis reflects microenvironmental and immunological variations [137] and mainly affects adults and older adults, irrespective of skin color and gender [138].…”

Section: Oral Candidiasismentioning

confidence: 99%

Interactions between systemic diseases and oral microbiota shifts in the aging community: A narrative review

Mosaddad,

Mahootchi,

Safari

et al. 2023

J Basic Microbiol

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As a gateway to general health and a diverse microbial habitat, the oral cavity is colonized by numerous microorganisms such as bacteria, fungi, viruses, and archaea. Oral microbiota plays an essential role in preserving oral health. Besides, the oral cavity also significantly contributes to systemic health. Physiological aging influences all body systems, including the oral microbial inhabitants. The cited effect can cause diseases by forming dysbiotic communities. Since it has been demonstrated that microbial dysbiosis could disturb the symbiosis state between the host and the resident microorganism, shifting the condition toward a more pathogenic one, this study investigated how the oral microbial shifts in aging could associate with the development or progression of systemic diseases in older adults. The current study focused on the interactions between variations in the oral microbiome and prevalent diseases in older adults, including diabetes mellitus, Sjögren's syndrome, rheumatoid arthritis, pulmonary diseases, cardiovascular diseases, oral candidiasis, Parkinson's disease, Alzheimer's disease, and glaucoma. Underlying diseases can dynamically modify the oral ecology and the composition of its resident oral microbiome. Clinical, experimental, and epidemiological research suggests the associations of systemic disorders with bacteremia and inflammation after oral microbial changes in older adults.

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Oral candidiasis: A retrospective study of 276 Brazilian patients

Cited by 8 publications

References 18 publications

Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans

Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans

Oral mucosal lesions - A study of 369 cases

Interactions between systemic diseases and oral microbiota shifts in the aging community: A narrative review

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