“…Aging is often accompanied by an irreversible decline in physiological function, especially metabolic function. The age‐associated metabolic phenotype, including decreased energy expenditure, increased fat mass accumulation, and insulin sensitivity deterioration (Guillory et al, ), can ultimately lead to age‐associated metabolic dysfunction, which correlates closely with several disease, such as type 2 diabetes (Lin et al, ), fatty liver (Gong, Tas, Yakar, & Muzumdar, ; Sheedfar et al, ), cardiovascular diseases (Dou et al, ), neurodegenerative diseases (Martocchia et al, ), and cancer (Topuz et al, ). Thus, exploring the underlying mechanisms of the age‐associated metabolic phenotype and developing drugs to treat aging‐associated metabolic dysfunction are of paramount importance.…”