“…γ-glutamyltranspeptidase (γ-GGT; EC 2.3.2.2), an over-expression enzyme associated with the growth and progression of ovarian, liver, colon and breast cancer compared to normal tissue (De Young et al, 1978 ; Shinozuka et al, 1979 ; Rao et al, 1986 ), plays important roles in many physiological and pathological processes (Pompella et al, 2006 ; Strasak et al, 2010 ), which is regarded as an important target for analysis and imaging in vitro or in vivo (Li et al, 2015b , 2016c ; Wang et al, 2015 , 2017b ; Park et al, 2016a , b ; Zhang et al, 2016a , b ; Liu et al, 2018 ). However, rarely related fluorescent probe could be qualified for the identification tumor by tracking the activity of γ-GGT enzyme in vivo (Urano et al, 2011 ), especially for NIR emission property, possessing good performances of avoiding auto-fluorescence and deeper tissue penetration (Gu et al, 2016a ).…”