Evaluation of the bioactive extract of actinomyces isolated from the Egyptian environment against aflatoxin B 1 -induce cytotoxicity, genotoxicity and oxidative stress in the liver of rats

El‐Nekeety, Aziza A.; Salman, Asmaa S.; Hathout, Amal S.; Sabry, Bassem A.; Abdel-Aziem, Sekena H.; Hassan, Nabila S.; Abdel-Wahhab, Mosaad A.

doi:10.1016/j.fct.2017.04.024

Cited by 20 publications

(9 citation statements)

References 106 publications

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“…Treatment of TP (300 mg/kg) fairly maintained hepatic chords and clear central vein was recorded without any kupffer cells infiltration. Similar findings were reported by El-Nekeety, 4 Bard and Naeem. 46 The results suggest that 300 mg/kg dose of TP to be effective in managing all the serological, biochemical and histological alterations towards…”

Section: Discussionsupporting

confidence: 91%

“…Its role in development and progression of hepatocellular carcinoma is extensively studied. [4][5] AFB1 itself is not toxic but when it undergoes oxidation via cytochrome 450 enzymes (CYP450) a reactive intermediate species named AFB1-8,9-epoxide (AFBO) is formed, which is responsible for toxicological manifestation. Metabolism of AFB1 generates reactive oxygen species (ROS), accumulation of these free radicals creates a condition of oxidative stress leading to loss of membrane integrity of hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

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Tephrosia purpurea Ameliorates Oxidative and Histological Alterations Induced by Aflatoxin B1 in Rats

Gupte

Rathour

Gupta

et al. 2022

IJPI

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Background: Tephrosia purpurea (TP), commonly known as wild indigo, is traditionally used in treatment of splenomegaly. It is an important ingredient of various Ayurvedic medicines used in treatment of liver diseases. Objectives: Thus, the study was undertaken to investigate the hepatoprotective efficacy of ethanolic extract of TP against Aflatoxin B1 (AFB1) induced liver injury. Materials and Methods: The ethanolic extract of TP was prepared by Soxhlet extraction method. Presence of polyphenols and antioxidant potential were assessed. The antiproliferative activity of extract was tested on HepG2 cells using MTT assay. For in vivo studies female Wistar rats were randomly divided into 6 groups with 6 animals in each. The entire regime was of 33 days. AFB1 was administered at 200 µg/kg dose and TP was administered at three different doses (100, 200 and 300 mg/kg). 24 hr after last treatment the animals were euthanised and liver and blood samples were collected. Results: 45.77± 2.53 µg/ ml IC 50 of extract was seen on HepG2 cells. A significant elevation in serum transaminases, triglycerides (TG) and LPO was seen after AFB1 intoxication. Whereas decline in activities of GSH, SOD, CAT, G6Pase and ATPase were observed. Treatment with different doses of TP restored its activities towards normal indices. Maximum recovery was seen with 300 mg/kg dose of TP. Conclusion: It may be concluded that TP possess hepatoprotective efficacy against AFB1 induced oxidative injury and it may prove to be of clinical use after further studies.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Tephrosia purpurea Ameliorates Oxidative and Histological Alterations Induced by Aflatoxin B1 in Rats

Gupte

Rathour

Gupta

et al. 2022

IJPI

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“…There are four aflatoxins produced naturally, B1, B2, G1, and G2. Aflatoxin B1 (AFB1) is the most common in feed and believed to be the most biologically active form causing cytotoxicity, genotoxicity and oxidative stress (Sweeney and Dobson, 1998); (Vaamonde et al, 2003) and (El-Nekeety et al, 2017). AFB1could be activated by cytochrome P450 (CYP450) into a highly reactive metabolite that reacts with DNA and proteins inducing genotoxicity and cytotoxicity (Cervino et al, 2007) and (Muhammad et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of Chemical and Biological Anti-mycotoxins on Performance, Haematological, Biochemical and Immunological Parameters of Broiler Chickens during Aflatoxicosis

Kilany

Helmi

Fares

et al. 2020

Egyptian Academic Journal of Biological Sciences, F. Toxicology

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The journal of Toxicology and pest control is one of the series issued twice by the Egyptian Academic Journal of Biological Sciences, and is devoted to publication of original papers related to the interaction between insects and their environment. The goal of the journal is to advance the scientific understanding of mechanisms of toxicity. Emphasis will be placed on toxic effects observed at relevant exposures, which have direct impact on safety evaluation and risk assessment. The journal therefore welcomes papers on biology ranging from molecular and cell biology, biochemistry and physiology to ecology and environment, also systematics, microbiology, toxicology, hydrobiology, radiobiology and biotechnology. www.eajbs.eg.net

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“…Fusarium strains are also responsible for banana wilt-disease, one of the most devastating plant diseases known [ 6 , 7 ]. The fungal infection of plants poses an additional danger to humans and livestock as they produce a variety of toxins that contaminate agriculture food products [ 8 , 9 , 10 , 11 , 12 ]. Extensive use of existing fungicides can be harmful to the environment as their accumulation might have adverse effects on other species of fungi, plants, and animals.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

Siupka

Hansen

Schier

et al. 2021

IJMS

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Crop infections by fungi lead to severe losses in food production and pose risks for human health. The increasing resistance of pathogens to fungicides has led to the higher usage of these chemicals, which burdens the environment and highlights the need to find novel natural biocontrol agents. Members of the genus Streptomyces are known to produce a plethora of bioactive compounds. Recently, researchers have turned to extreme and previously unexplored niches in the search for new strains with antimicrobial activities. One such niche are underground coal mine environments. We isolated the new Streptomyces sp. MW-W600-10 strain from coal mine water samples collected at 665 m below ground level. We examined the antifungal activity of the strain against plant pathogens Fusarium culmorum DSM62188 and Nigrospora oryzae roseF7. Furthermore, we analyzed the strain’s biosynthetic potential with the antiSMASH tool. The strain showed inhibitory activity against both fungi strains. Genome mining revealed that it has 39 BGCs, among which 13 did not show similarity to those in databases. Additionally, we examined the activity of the Streptomyces sp. S-2 strain isolated from black soot against F. culmorum DSM62188. These results show that coal-related strains could be a source of novel bioactive compounds. Future studies will elucidate their full biotechnological potential.

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Evaluation of the bioactive extract of actinomyces isolated from the Egyptian environment against aflatoxin B 1 -induce cytotoxicity, genotoxicity and oxidative stress in the liver of rats

Cited by 20 publications

References 106 publications

Tephrosia purpurea Ameliorates Oxidative and Histological Alterations Induced by Aflatoxin B1 in Rats

Tephrosia purpurea Ameliorates Oxidative and Histological Alterations Induced by Aflatoxin B1 in Rats

Effects of Chemical and Biological Anti-mycotoxins on Performance, Haematological, Biochemical and Immunological Parameters of Broiler Chickens during Aflatoxicosis

Antifungal Activity and Biosynthetic Potential of New Streptomyces sp. MW-W600-10 Strain Isolated from Coal Mine Water

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