Effects of Chemical and Biological Anti-mycotoxins on Performance, Haematological, Biochemical and Immunological Parameters of Broiler Chickens during Aflatoxicosis

Kilany, Omnia; Helmi, Rania Abdou; Fares, Ibrahim; Mahmoud, Mostafa

doi:10.21608/eajbsf.2020.84488

Cited by 5 publications

(8 citation statements)

References 76 publications

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“…There was also a shortage of platelets in all treatments compared to the control, while platelets increased after treatments. These results are in agreement with those by Kilany et al [34] and Tarabees et al [35]. The histological examinations of the colon and spleen demonstrated that the Piroxicam drug had a severe effect on them.…”

Section: Discussionsupporting

confidence: 93%

Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis

Khattab

Darwish

Othman

et al. 2022

Biol Trace Elem Res

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Selenium-enriched Lactobacillus plantarum and Bifidobacterium longum mutants were used as a protector against Piroxicam-induced ulcerative colitis (UC). In this study, 32 BALB/c male mice were distributed to four groups: the control group, the Piroxicam group which was given 0.8 mg Piroxicam, SP and SB groups which were given 0.8 mg Piroxicam, and plus Lactobacillus plantarum and Bifidobacterium longum selenium-enriched mutants, respectively. Bodyweight; serum content of IgG, IgM, TNF-α, IL-2, IL-6, and IL-10; CBC; myeloperoxidase enzyme activity; histopathological examination of colon and spleen; and expression of TNF-α, IL-2, IL-6, and IL-10 genes in colon and spleen with qRT-PCR were determined. Bodyweight was found to reduce in the Piroxicam group and then recovery in the SB group. Serum content of IgG, IL-2, and IL-10 reduced in the Piroxicam group, whereas IgG, TNF-α, and IL-6 increased in the Piroxicam group in comparison to the other groups. Myeloperoxidase activity witnessed a significant increase in the Piroxicam group compared with the other groups. No significant differences were observed between all groups in measurements of red cells, hemoglobin, neutrophil, monocyte, eosinophil, and basophil in blood. Meanwhile, the white blood cells and platelets recorded the highest and lowest value, respectively, in the Piroxicam group. The colon of the Piroxicam group showed a noticeably massive infiltration of inflammatory cells in the lamina propria. These inflammations were mildly reduced in the SP group, while the reduction in the SB group was significant. In the Piroxicam group, splenic parenchyma saw an increase in the number of melanomacrophages, while hypertrophic plasma cells were observed in the SP group. The spleen of the SB group exhibits a nearly normal form. TNF-α and IL-6 genes had significantly upregulated in the colon of the Piroxicam group compared to the control group, while they were significantly downregulated in the SB group. In contrast, IL-2 and IL-10 genes had upregulated in the colon of the SB group compared to the control groups, while they had downregulated in the Piroxicam group. The expression of these genes had not recorded significant differences between all groups in the spleen. Therefore, this study recommends Bifidobacterium longum selenium-enriched mutants as anti-inflammatory and immunomodulatory supplements.

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Section: Discussionsupporting

confidence: 93%

Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis

Khattab

Darwish

Othman

et al. 2022

Biol Trace Elem Res

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“…Hepatic sections from broiler group after receiving Synertox ® showed fibrous tissue proliferation infiltrated with mixed leukocytes and few leukocytic cells infiltration around central vein. These findings were in the line with kilany et al (38) who reported that liver treated with product similar to Synertox ® showed portal and interstitial leucocytic aggregation in hepatic cells.…”

Section: Efficacy Of T-nil Plus® and Synertox® On Chickensupporting

confidence: 91%

“…Renal sections from broiler group after receiving Synertox ® showed congested interstitial blood vessels and mild interstitial edema. These results were relatively similar to those of kilany et al (38) who reported that kidney treated with product similar to Synertox ® showed acute cell swelling of renal tubules and congestion. Duodenal sections from broiler treated groups (G2, G3) showed desquamated villous epithelium due to the increase in lymphocyte populations due to the anti-inflammatory role of the tested agents in the duodenum, these results were in accordance with those of Awadin et al (73)…”

Section: Efficacy Of T-nil Plus® and Synertox® On Chickensupporting

confidence: 91%

Pharmacological effect of T-NilPlus® and Synertox®, commercial anti-mycotoxins, on broiler chickens in Egypt

et al. 2022

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The present study was carried out to investigate the potential ameliorative effect of two commercial anti-mycotoxins, containing Saccharomyces cerevisiae cell wall as prebiotic (T-Nil Plus®) and Bacillus subtilis as probiotic (Synertox®) on performance and some biochemical parameters of broilers. One hundred and twenty chicks one day old chicks were divided into 3 equal groups. 1st group was served as control, 2nd group was given T-Nil Plus®. The 3rd group was given Synertox®. Chicken’s performance was estimated. Serum samples obtained from each group for biochemical analysis. Tissues samples were collected for histopathological examination. The obtained results revealed that, T-Nil plus® induced a marked reduction in body weight gain and an elevation in Feed consumption, moreover, a marked elevation in, alanine aminotransferase (ALT), creatinine and malondialdehyde (MDA) and a marked reduction in aspartate aminotransferase (AST) was detected. While Synertox® caused a significant decrease in body weight, body weight gain and no change in feed conversion rate (FCR) and a marked elevation in ALT, creatinine and a marked reduction in AST and nitric oxide (NO) and it caused a significant reduction in serum glucose level of the birds. In conclusion, Synertox® induced a powerful effect comparing to T-Nil Plus®, as it induces a good FCR and increases the response of the birds against oxidative stress.

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“…The elevated serum level of creatinine in this investigation demonstrated aflatoxin's nephrotoxicity. An early sign of aflatoxicosis was this rise in creatinine levels (Kilany et al, 2020). HSCAS and SC substantively (p<0.05) improved serum biochemical items, signifying that they were successful in warding off AFB1 by inhibiting its adverse influence by raising serum conesituents (Attia et al, 2013;.…”

Section: Discussionmentioning

confidence: 88%

Potential of Protective Effect of Hydrated Sodium Calcium Aluminosilicate and Saccharomyces cerevisiae against Dietary Aflatoxicosis in Broiler Chicks

Hassan¹,

Abou-shehema²,

Zayed³

et al. 2022

JAHP

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This study investigated the defensive effect of dietary Hydrated sodium calcium aluminosilicate (HSCAS) (0.5%) and Saccharomyces cerevisiae (SC) (0.1%) on the preclusion of aflatoxin-B1 (AFB1) toxicity in broiler chicken during 1 -42 days of age. Eight hundred broiler chicks were arbitrarily assigned for 8 treatments of 5 replicates (each contained 20 chicks). On the other hand, chickens were offered the basal dietas Negative Control (NC, group 1); the other three groups 2, 3, and 4 were fed NC supplemented with 0.5% HSCAS, SC and HSCAS plus SC respectively, group 5 chicks were fed a basal diet contaminated with 1ppm AFB1 as Positive Control (PC), the other three groups 6, 7 and 8 were fed PC supplemented with 0.5% HSCAS, SC, and HSCAS plus SC respectively. Results exhibited that broiler chicks fed with a PC diet showed significantly (P<0.05) a worse feed conversion ratio and inferior daily body weight during the experimental period. Furthermore, AFB1 toxicity at 1mg dose significantly (P<0.05) increased creatinine, uric acid concentrations, alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities and significantly (P<0.05) reduced the antibody titer against sheep red blood cells (SRBC), total protein, albumin values in broilers serum compared with ngative control. Aflatoxins supplementation significantly (P<0.05) increased malondialdehyde values in liver and significantly (P<0.05) diminished the reduced glutathione (GSH), glutathione S-transferase (GST). In addition to, dissemination of aflatoxin residue in broilers liver was detected. Nevertheless, dietary addition of HSCAS and SC, in separate and combined forms, alleviated the above-mentioned alterations. The combination of HSCAS with SC was more efficient than having them in a separate form.

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Effects of Chemical and Biological Anti-mycotoxins on Performance, Haematological, Biochemical and Immunological Parameters of Broiler Chickens during Aflatoxicosis

Cited by 5 publications

References 76 publications

Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis

Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis

Pharmacological effect of T-NilPlus® and Synertox®, commercial anti-mycotoxins, on broiler chickens in Egypt

Potential of Protective Effect of Hydrated Sodium Calcium Aluminosilicate and Saccharomyces cerevisiae against Dietary Aflatoxicosis in Broiler Chicks

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