Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: A systematic review and meta-analysis

Misiak, Błażej; Stańczykiewicz, Bartłomiej; Łaczmański, Łukasz; Frydecka, Dorota

doi:10.1016/j.schres.2017.03.031

Cited by 120 publications

(77 citation statements)

References 59 publications

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“…The sensitivity analysis in the study by Misiak and colleagues (Misiak et al, 2017) rendered LDL cholesterol non-significant, which also mirrors our findings.…”

Section: A Note On Versionssupporting

confidence: 89%

“…Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. The study by Błażej Misiak and colleagues (Misiak et al, 2017) provides evidence that antipsychoticnaïve patients with first-episode non-affective psychosis may present with subclinical dyslipidaemia, namely a significantly lower total cholesterol, LDL cholesterol, HDL cholesterol, and higher triglycerides, compared with healthy controls. The authors completed sensitivity analyses to view the effect of confounders they named as age, sex, BMI and smoking status.…”

Section: A Note On Versionsmentioning

confidence: 99%

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Letter to the Editor: Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis

Perry

Singh

2018

Schizophrenia Research

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A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. The study by Błażej Misiak and colleagues (Misiak et al., 2017) provides evidence that antipsychoticnaïve patients with first-episode non-affective psychosis may present with subclinical dyslipidaemia, namely a significantly lower total cholesterol, LDL cholesterol, HDL cholesterol, and higher triglycerides, compared with healthy controls. The authors completed sensitivity analyses to view the effect of confounders they named as age, sex, BMI and smoking status.The findings however are interesting and partly mirror our own meta-analysis (Perry et al., 2016), when we found significantly decreased HDL and total cholesterol in patients with first-episode psychosis compared with healthy matched controls. The sensitivity analysis in the study by Misiak and colleagues (Misiak et al., 2017) rendered LDL cholesterol non-significant, which also mirrors our findings.Our work primarily aimed to view the association between first-episode psychosis and subclinical dysglycaemia, as we hypothesized that intrinsic disease links, possibly with an inflammatory basis, may

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“…The sensitivity analysis in the study by Misiak and colleagues (Misiak et al, 2017) rendered LDL cholesterol non-significant, which also mirrors our findings.…”

Section: A Note On Versionssupporting

confidence: 89%

Section: A Note On Versionsmentioning

confidence: 99%

Letter to the Editor: Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis

Perry

Singh

2018

Schizophrenia Research

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“…[116][117][118][119][120] Lower levels of total cholesterol in MDD patients with SI, compared to non-suicide MDD subjects, have been reported in a recent meta-analysis. 121 Low triglycerides, low levels of low-density lipoprotein (LDL) and low levels of high-density lipoprotein (HDL) are significantly related to suicidality in MDD patients. 122,123 A proposed hypothesis suggested that reduced cholesterol levels may reduce serotonin precursors and modify the functions and viscosity of serotonin receptors and transporters, by increasing one's tendencies towards impulsive, aggressive, and suicidal behaviour.…”

Section: Metabolic Patternmentioning

confidence: 99%

Understanding the Complex of Suicide in Depression: from Research to Clinics

Orsolini

Latini²,

Pompili³

et al. 2020

Psychiatry Investig

197

149

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Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15–17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.Methods A broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of ‘Major Depressive Disorder’ and ‘Suicide’ as following: ((<i>suicide</i> [Title/Abstract]) AND (<i>major depressive disorder</i> [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.Results Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.Conclusion The present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.

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“…Dyslipidaemia has been shown to be associated with first-episode psychosis (Perry et al, 2016, Misiak et al, 2017b, and an abnormal inflammatory response in patients with first-episode psychosis (Russell et al, 2015, Miller et al, 2013. It is therefore possible that our hypothesis may extend to other elements of the metabolic syndrome, and this may warrant future research.…”

Section: Strengths and Limitationsmentioning

confidence: 90%

Associated illness severity in schizophrenia and diabetes mellitus: A systematic review

Perry

Salimkumar

Green

et al. 2017

Psychiatry Research

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(2017) Associated illness severity in schizophrenia and diabetes mellitus : a systematic review. Psychiatry research. Permanent WRAP URL:http://wrap.warwick.ac.uk/89163 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. ResultsEleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results. ConclusionWhilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors' knowledge, this is the first systematic review conducted to address this question.

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Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: A systematic review and meta-analysis

Cited by 120 publications

References 59 publications

Letter to the Editor: Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis

Letter to the Editor: Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis

Understanding the Complex of Suicide in Depression: from Research to Clinics

Associated illness severity in schizophrenia and diabetes mellitus: A systematic review

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