Associated illness severity in schizophrenia and diabetes mellitus: A systematic review

Perry, Benjamin Ian; Salimkumar, Dhanya; Green, Daniel; Meakin, Anne; Gibson, Andrew; Mahajan, Deepali; Tahir, Tayyeb A.; Singh, Swaran P.

doi:10.1016/j.psychres.2017.06.027

Cited by 18 publications

(7 citation statements)

References 40 publications

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“…A shared disease process may link dysglycaemia, immune activation and psychotic symptoms. 8,36 Previous work using the same birth cohort has found that childhood IL-6 is longitudinally associated with PEs at age 18 years. 16 We found that IL-6 correlates with markers of dysglycaemia longitudinally.…”

Section: Discussionmentioning

confidence: 99%

Dysglycaemia, Inflammation and Psychosis: Findings From the UK ALSPAC Birth Cohort

Perry

Upthegrove

Thompson

et al. 2018

Schizophrenia Bulletin

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Background: Psychosis is associated with both dysglycaemia and low-grade inflammation, but population-based studies investigating the interplay between these factors are scarce. Aims: (1) To explore the direction of association between markers of dysglycaemia, inflammation and psychotic experiences (PEs); and (2) To explore whether dysglycaemia moderates and/or mediates the association between inflammation and PEs. Method: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were modeled using logistic and linear regression to examine cross-sectional and longitudinal associations between markers of dysglycaemia (ages 9 and 18), interleukin-6 (IL-6) (age 9), and PEs (ages 12 and 18). We tested for an interaction between dysglycaemia and IL-6 on risk of PEs at age 18, and tested whether dysglycaemia mediated the relationship between IL-6 and PEs. Results: Based on 2627 participants, at age 18, insulin resistance (IR) was associated with PEs (adjusted OR = 2.32; 95% CI, 1.37-3.97). IR was associated with IL-6 both crosssectionally and longitudinally. Interaction analyses under a multiplicative model showed that IR moderated the association between IL-6 at age 9 and PEs at age 18 (adjusted OR for interaction term = 2.18; 95% C.I., 1.06-4.49). Mediation analysis did not support a model of IR mediating the relationship between IL-6 and PEs. Implications: IR is associated with PEs in young people even before the onset of clinical psychosis. Metabolic alterations may interact with childhood inflammation to increase risk of PEs. The findings have implications for clinical practice and future research.

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Section: Discussionmentioning

confidence: 99%

Dysglycaemia, Inflammation and Psychosis: Findings From the UK ALSPAC Birth Cohort

Perry

Upthegrove

Thompson

et al. 2018

Schizophrenia Bulletin

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“…There is evidence that a hyperglycaemic state increases blood brain barrier permeability (Hawkins et al, 2007). Thus diabetes is relate to a heightened systemic inflammatory response and increased susceptibility of the inflammatory cytokines to enter the central nervous system (Perry et al, 2017).…”

Section: Type 2 Diabetes Obesity and Inflammationmentioning

confidence: 99%

Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus

Zhao

Yang

Wai

et al. 2018

Critical Reviews in Food Science and Nutrition

133

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Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious public health threat worldwide. It is a severe endocrine metabolic disorder which has the ability to induce serious complications in all kinds of organs. Although the mechanisms of anti-diabetics have been described before, we focus here on the cellular and physiological mechanisms on the modulation of insulin and blood glucose. As obesity and inflammation are intimately associated with the development of T2DM, the possible relationships of them were described. We investigated and discussed the effects of gut microbiota on insulin resistance in human clinical trials and the potential mechanisms and roles whereby gut microbiota improve glucose metabolism. Phytochemicals have historically underlied their effects with therapeutic potential on T2DM, and nowadays still represent an important pool for the identification of novel drug leads. The anti-diabetic effects of natural species that are used in medicines or as nutraceuticals were described.The objective of the present study was to make a systematic review on glucose metabolism in T2DM as well as to explore the relationship between glucose metabolism and natural phytochemicals.

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“…Interestingly, different studies also suggest overlapping mechanisms between psychotic disorders and type 2 diabetes (16) and metabolic comorbidity may manifest at an early stage in psychotic disorders (17). Thus, we hypothesize that inflammatory mechanisms involved in the development of psychotic disorders are also underlying the comorbid metabolic related diseases such as type 2 diabetes in these patients (2,18,19).…”

Section: Introductionmentioning

confidence: 83%

An association between YKL‐40 and type 2 diabetes in psychotic disorders

Dieset

Mørch

Hope

et al. 2018

Acta Psychiatr Scand

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OA. An association between YKL-40 and type 2 diabetes in psychotic disorders.Objective: This study examines if YKL-40 is increased in individuals with psychotic disorders and if elevated YKL-40 levels at baseline is associated with subsequent development of type 2 diabetes. Method: A total of 1383 patients with a diagnosis of schizophrenia or affective psychosis and 799 healthy controls were recruited in the period 2002-2015. Plasma YKL-40 and metabolic risk factors were measured and medication was recorded. Using national registry data, association between baseline risk factors and later development of type 2 diabetes was assessed using Cox proportional hazards models. Results: Plasma YKL-40 was higher in patients vs. healthy controls also after adjusting for metabolic risk factors, with no difference between the schizophrenia and affective psychosis groups. Patients were diagnosed with type 2 diabetes at a significantly younger age. Multivariate Cox regression analyses showed that elevated YKL-40 (hazard ratio (HR) = 5.6, P = 0.001), elevated glucose (HR = 3.6, P = 0.001), and schizophrenia diagnosis (HR = 3.0, P = 0.014) at baseline were associated with subsequent development of type 2 diabetes. Conclusions: Patients with psychotic disorders have at baseline increased levels of YKL-40 beyond the effect of comorbid type 2 diabetes and metabolic risk factors. Elevated YKL-40 level at baseline is associated with later development of type 2 diabetes.

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Associated illness severity in schizophrenia and diabetes mellitus: A systematic review

Cited by 18 publications

References 40 publications

Dysglycaemia, Inflammation and Psychosis: Findings From the UK ALSPAC Birth Cohort

Dysglycaemia, Inflammation and Psychosis: Findings From the UK ALSPAC Birth Cohort

Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus

An association between YKL‐40 and type 2 diabetes in psychotic disorders

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