Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial

Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life

“…The Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC 2010 ) clinical trial separately showed trends toward a reduced risk of asthma or persistent wheezing in offspring of mothers receiving antenatal vitamin D 3 supplementation, but which did not reach statistical significance due to underpowering. Combined secondary analyses from both cohorts, however, later demonstrated a significant protective effect of antenatal vitamin D supplementation against asthma/recurrent wheeze in the offspring, an effect which was more pronounced in women with higher 25(OH)D levels (>30 ng/mL) at trial entry . Multiple measurements of vitamin D levels during pregnancy and in the first few years of life alongside detailed capture of maternal and offspring vitamin D supplementation in future studies would allow for more detailed subgroup analyses.…”

Dietary supplementation usage by pregnant women in Silesia — population based study

“…journals.viamedica.pl/ginekologia_polska risk of preterm birth and low birth weight in neonates, as well as pre-eclampsia in pregnant women. However, recent data has shown that the impact of low levels of 25-hydroxyvitamin D during pregnancy may also contribute to development of eczema, wheezing and asthma in children [13,14]. Iodine deficiency may lead to hypothyroidism in both mother and child.…”

Ethnic differences in the association between maternal vitamin D status and offspring asthma and wheeze: Findings from the Born in Bradford cohort study

“…Risk factors for low vitamin D levels include dark skin, 3 and ethnic variations in the prevalence of asthma have previously been reported. 4,5 Whilst it is known that rates of both circulating vitamin D levels and childhood asthma differ by ethnicity, to our knowledge, no UK study as previously investigating ethnic differences in the association between maternal vitamin D and offspring asthma. Our aims were to quantify maternal vitamin D levels and the prevalence of asthma and wheeze in a bi-ethnic cohort of UK-born children and to explore the relationship between them.…”