Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis

Wang, Xia; Cicuttini, Flavia Maria; Jin, Xingzhong; Wluka, Anita E.; Han, Weiyu; Zhu, Zhaohua; Blizzard, Leigh; Antony, Benny; Winzenberg, Tania; Jones, Graeme; Ding, Changhai

doi:10.1016/j.joca.2017.02.804

Cited by 54 publications

(48 citation statements)

References 44 publications

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“…There were more OMERACT‐OARSI (Outcome Measures in Rheumatology Clinical trials – Osteoarthritis Research Society International) responders in the vitamin D group than the placebo group (35% vs . 25%, P = 0.029) and vitamin D supplementation reduced the progression of bone marrow lesions and effusion‐synovitis volume . Again, the clinical significance of a 2 mL difference in the volume of effusion‐synovitis compared to placebo is unknown.…”

Section: Clinical Trials Of Vitamin D In Oamentioning

confidence: 99%

Vitamin D and osteoarthritis: disparity between observational studies and clinical trials

Antony

Ding

2017

Int J Rheum Dis

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Section: Clinical Trials Of Vitamin D In Oamentioning

confidence: 99%

Vitamin D and osteoarthritis: disparity between observational studies and clinical trials

Antony

Ding

2017

Int J Rheum Dis

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“…Manual segmentation is considered to be an accurate and reliable method for the assessment of synovitis on CE‐MRI, and effusion‐synovitis on noncontrast enhanced MRI, with intraobserver agreement up to 0.94 and 0.97 . Manual segmentation is, however, time‐consuming for the measurement of synovitis and can take between 45 to 120 min per case .…”

Section: Discussionmentioning

confidence: 99%

“…Manual segmentation is considered to be an accurate and reliable method for the assessment of synovitis on CE-MRI, and effusion-synovitis on noncontrast enhanced MRI, with intraobserver agreement up to 0.94 6 and 0.97. 22 Manual segmentation is, however, time-consuming for the measurement of synovitis and can take between 45 to 120 min per case. 10,11 The timings of STV assessment using our approach are comparable to previous studies that have examined the use of semiautomated segmentation software in knee OA.…”

Section: Discussionmentioning

confidence: 99%

Measurement of synovial tissue volume in knee osteoarthritis using a semiautomated MRI‐based quantitative approach

Perry

Gait

O’Neill

et al. 2019

Magnetic Resonance in Med

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Purpose Synovitis is common in knee osteoarthritis and is associated with both knee pain and progression of disease. Semiautomated methods have been developed for quantitative assessment of structure in knee osteoarthritis. Our aims were to apply a novel semiautomated assessment method using 3D active appearance modeling for the quantification of synovial tissue volume (STV) and to compare its performance with conventional manual segmentation. Methods Thirty‐two sagittal T 1 ‐weighted fat‐suppressed contrast‐enhanced MRIs were assessed for STV by a single observer using 1) manual segmentation and 2) a semiautomated approach. We compared the STV analysis using the semiautomated and manual segmentation methods, including the time taken to complete the assessments. We also examined the reliability of STV assessment using the semiautomated method in a subset of 12 patients who had participated in a clinical trial of vitamin D therapy in knee osteoarthritis. Results There was no significant difference in STV using the semiautomated quantitative method compared to manual segmentation, mean difference = 207.2 mm 3 (95% confidence interval −895.2 to 1309.7). The semiautomated method was significantly quicker than manual segmentation (18 vs. 71 min). For the semiautomated method, intraobserver agreement was excellent (intraclass correlation coefficient (3,1) = 0.99) and interobserver agreement was very good (intraclass correlation coefficient (3,1) = 0.83). Conclusion We describe the application of a semiautomated method that is accurate, reliable, and quicker than manual segmentation for assessment of STV. The method may help increase efficiency of image assessment in large imaging studies and may also assist investigation of treatment efficacy in knee osteoarthritis.

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“…Effusion-synovitis volume will be measured using a semiautomated segmentation method according . Effusion-synovitis volume was highly correlated with effusion-synovitis score (rho 1⁄4 0.77, P < 0.01 for total, rho 1⁄4 0.91, P < 0.01 for suprapatellar pouch, and rho 1⁄4 0.77, P < 0.01 for central portion) [45].…”

Section: Knee Effusion-synovitismentioning

confidence: 93%

KARAOKE: Krill oil versus placebo in the treatment of knee osteoarthritis: protocol for a randomised controlled trial

Laslett

Antony

Wluka

et al. 2019

Preprint

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Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis

Abstract: This highly reproducible effusion-synovitis volume measurement could be a promising outcome measure in OA trials. Vitamin D supplementation could retard the progression of effusion-synovitis which can potentially benefit people with an inflammatory OA phenotype.

Cited by 54 publications

References 44 publications

Vitamin D and osteoarthritis: disparity between observational studies and clinical trials

Vitamin D and osteoarthritis: disparity between observational studies and clinical trials

Measurement of synovial tissue volume in knee osteoarthritis using a semiautomated MRI‐based quantitative approach

KARAOKE: Krill oil versus placebo in the treatment of knee osteoarthritis: protocol for a randomised controlled trial

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