KARAOKE: Krill oil versus placebo in the treatment of knee osteoarthritis: protocol for a randomised controlled trial

Laslett, Laura L; Antony, Benny; Wluka, A.; Hill, Catherine; March, Lyn; Keen, Helen; Otáhal, Petr; Cicuttini, F.; Jones, Gary L.

doi:10.21203/rs.2.12385/v2

Cited by 1 publication

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“…Other studies [ 19 , 25 ] also confirmed that krill oil had the ability to reduce C-reactive protein levels, which are the markers of systemic inflammation. Oxidative stress and inflammation are the main cause of knee osteoarthritis (OA) pathogenesis and krill oil could not only ameliorate knee pain [ 26 ] but also reduce systemic inflammation of the body caused by OA [ 27 ]. In terms of inflammatory bowel disease (IBD), ω-3 PUFA and astaxanthin in KO also show the significantly anti-inflammatory property in the management with promising results [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Microemulsions Based on Antarctic Krill Oil

et al. 2020

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Antarctic krill oil is high in nutritional value and has biological functions like anti-inflammation and hypolipidemic effects. But it has and unpleasant smell, and unsaturated fatty acids are prone to oxidative deterioration. Its high viscosity and low solubility in water make it difficult for processing. Microemulsion can be a new promising route for development of krill oil product. We determined a formula of krill oil-in-water microemulsion with krill oil: isopropyl myristate = 1:3 as oil phase, Tween 80:Span 80 = 8:2 as surfactant, ethanol as co-surfactant and the mass ratio of surfactant to co-surfactant of 3:1. After screening the formula, we researched several characteristics of the prepared oil-in-water microemulsion, including electrical conductivity, microstructure by transmission electron microscope and cryogenic transmission electron microscope, droplet size analysis, rheological properties, thermal behavior by differential scanning calorimeter and stability against pH, salinity, and storage time.

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