Fuzheng Huayu Formula (扶正化瘀方) prevents rat renal interstitial fibrosis induced by HgCl2 via antioxidative stress and down-regulation of nuclear factor-kappa B activity

Yuan, Jianmin; Yue, Tao; Wang, Qinglan; Shen, Li; Liu, Chenghai

doi:10.1007/s11655-016-2540-z

Cited by 14 publications

(8 citation statements)

References 26 publications

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“…Hydroxyproline is used for the estimation of the collagen content, considering that collagen contained 12.7% hydroxyproline by weight [27]. Our results were parallel to those of Yuan et al [28] who concluded that renal and liver fibrosis are induced by HgCl 2 , demonstrated by a significant elevation (p ≤ 0.001) of the hydroxyproline content in liver and kidney tissues compared to control. Consequently, treatment with DPPD significantly attenuated hydroxyproline and collagen deposition (p ≤ 0.001) in animals [19].…”

Section: Discussionsupporting

confidence: 88%

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Nabil

Elshemy

Asem

et al. 2020

Journal of Toxicology

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Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, and tissue damage. Oxidative stress is caused by an imbalance between free radicals’ production and cellular antioxidant defense systems. In the present study, we investigated the effect of N N′-diphenyl-1, 4-phenylenediamine (DPPD) antioxidant activity against mercury chloride- (HgCl2-) induced renal and hepatic toxicity. Thirty adult female Sprague Dawley rats were divided into three equal groups: the first group was injected with saline only and served as a control, the second group was injected with HgCl2, and the third group received DPPD + HgCl2 rats injected with HgCl2 without treatment showing a significant increase in alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and uric acids compared to control. Moreover, the second group showed a significant reduction in the activity of the antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH)) in addition to a marked increase in the malondialdehyde (MDA) content, histopathological alterations, collagen deposition, CD8%, CD4%, and TGF-β% in kidney and liver tissues compared with the control group. Treatment with DPPD showed significant recovery (p≤0.001) in all previous parameters and histopathological examination. In conclusion, we suggested that DPPD may have a promising antioxidant capacity, gives it the applicability to be used as a prophylactic agent against mercury-induced hepatorenal cytotoxicity in the future.

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Section: Discussionsupporting

confidence: 88%

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Nabil

Elshemy

Asem

et al. 2020

Journal of Toxicology

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“…Recent studies have shown that oxidative stress is one of the important causes of kidney damage, especially of tubulointerstitial fibrosis [ 24 ]. The increase of oxidative stress reaction products (mainly ROS) may play a very important role in the tubulointerstitial lesions in UUO rats; the inhibition of oxidative stress can alleviate the RIF process [ 25 ]. ROS not only can directly play a role in cytotoxicity, but also can be used as a signal molecule to regulate the expression of some related genes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Qingshen Granules on the Oxidative Stress‐NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats

Jin

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Background. The activation of NF-kappa B (NF/kB) signaling pathway plays an important role in the process of epithelial-mesenchymal transition (EMT) and renal interstitial fibrosis (RIF) in renal tubules. The process of oxidative stress reaction in kidney is via excessive reactive oxygen species (ROS) production to activate NF/kB signaling pathway. Qingshen Granule (QSG) is an effective Chinese formula utilized to treat chronic renal failure. Previous studies confirmed that QSG could inhibit RIF in unilateral ureteral obstruction (UUO) rats. In this study, we used UUO rats to investigate the effects of QSG on oxidative stress and the activation of NF/kB signaling. Seventy male Sprague-Dawley (SD) rats were randomly divided into a sham group, UUO model group, Qingshen Granules (QSG) high-dose, medium-dose, and low-dose groups, PDTC group, and candesartan group (10 rats in each group). Our study demonstrated that oxidative stress-NF/kB signal pathway contributed to the formation of UUO renal interstitial fibrosis. QSG may protect against RIF by inhibiting the oxidative stress-NF/kB signal pathway, reducing inflammation, and improving renal tubular EMT.

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“…Therefore, tonifying kidney-qi, including invigorating kidney-yang and nourishing kidney-yin, is the main consideration in clinical practice. Yougui pill, a yang-tonic prescription, is used for the empirical treatment of renal fibrosis [39] and Fuzheng huayu formula is a SFDA approved anti-fibrotic medicine in China, which can not only activate blood and remove stasis, but also nourish yin [40].…”

Section: Suggested Mechanismsmentioning

confidence: 99%

“…Decreased NF-κB levels has been reported to attenuate renal injury and inflammation in different animal models of CKD [70,71]. Therefore, antiinflammation agents are attractive therapeutic target for attenuating the inflammatory process, such as Fuzheng Huayu Formula [40].…”

Section: Suggested Mechanismsmentioning

confidence: 99%

Chinese Herbal Formulas and Renal Fibrosis: An Overview

Shen

Wang

Rahman

et al. 2018

CPD

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All forms of chronic kidney disease (CKD) eventually lead to renal fibrosis irrespective of its origin. It is generally characterized by an excessive accumulation and deposition of extracellular matrix (ECM) and to date, no ideal treatment has been established. Bian-Zheng-Lun-Zhi (syndrome differentiation and treatment), a classic feature of traditional Chinese Medicine (TCM), is a unique method used to diagnose and treat the pathology of a disease. Zheng (syndrome) is used to demonstrate the nature of a disease completely in an extensive and specific manner. Chinese herbal formulas are determined according to TCM theory and this review highlights these formulas and suggests a possible mechanism for their use in the treatment of renal fibrosis.

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Fuzheng Huayu Formula (扶正化瘀方) prevents rat renal interstitial fibrosis induced by HgCl2 via antioxidative stress and down-regulation of nuclear factor-kappa B activity

Cited by 14 publications

References 26 publications

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Effects of Qingshen Granules on the Oxidative Stress‐NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats

Chinese Herbal Formulas and Renal Fibrosis: An Overview

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