Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Nabil, Ahmed; Elshemy, Mohamed M.; Asem, Medhat; Gomaa, Heba F.

doi:10.1155/2020/4127284

Cited by 14 publications

(20 citation statements)

References 34 publications

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“…Mercury (Hg) is a persistent bio-accumulative toxic heavy metal with unique physicochemical properties of public health concern since their natural and anthropogenic diffusions still induce high risk to human and environmental health (Bjørklund et al, 2017). Mercury is present in the environment (Nabil et al, 2020) in different forms; inorganic mercury, organic mercury, and metallic or elemental mercuric compounds (Park and Zheng, 2012). It is an extremely toxic element that quickly disturbs the cardiovascular and nervous systems.…”

Section: Introductionmentioning

confidence: 99%

Toxicological effects of thimerosal on rat kidney: a histological and biochemical study

et al. 2023

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Thimerosal is an organomercurial compound, which is used in the preparation of intramuscular immunoglobulin, antivenoms, tattoo inks, skin test antigens, nasal products, ophthalmic drops, and vaccines as a preservative. In most of animal species and humans, the kidney is one of the main sites for mercurial compounds deposition and target organs for toxicity. So, the current research was intended to assess the thimerosal induced nephrotoxicity in male rats. Twenty-four adult male albino rats were categorized into four groups. The first group was a control group. Rats of Group-II, Group-III, and Group-IV were administered with 0.5µg/kg, 10µg/kg, and 50µg/kg of thimerosal once a day, respectively. Thimerosal administration significantly decreased the activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), glutathione reductase (GR), glutathione (GSH), and protein content while increased the thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (H2O2) levels dose-dependently. Blood urea nitrogen (BUN), creatinine, urobilinogen, urinary proteins, kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) levels were substantially increased. In contrast, urinary albumin and creatinine clearance was reduced dose-dependently in thimerosal treated groups. The results demonstrated that thimerosal significantly increased the inflammation indicators including nuclear factor kappaB (NF-κB), tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) levels and cyclooxygenase-2 (COX-2) activities, DNA and histopathological damages dose-dependently. So, the present findings ascertained that thimerosal exerted nephrotoxicity in male albino rats.

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Section: Introductionmentioning

confidence: 99%

Toxicological effects of thimerosal on rat kidney: a histological and biochemical study

et al. 2023

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“…(2017) ; Elblehi et al. (2019) and Nabil et al.. (2020) have reported that mercuric chloride causes a significant elevation in AST, ALT, urea and creatinine levels and induction of hepatorenal dysfunction. The higher urea and creatinine levels reflect progressive renal insufficiency in rats treated with mercuric chloride ( Oriquat et al., 2012 ).…”

Section: Discussionmentioning

confidence: 98%

“…Mercury is one of the most serious environmental pollutants ( Mesquita et al., 2016 ; Nabil et al., 2020 ), which can be found in water, air and soil. There are several sources of mercury exposure, including dental amalgam fillings ( Bengtsson and Hylander, 2017 ), seafood ( Dadar et al., 2016 ; Kuras et al., 2017 ), vaccines ( Mitkus et al., 2014 ) and energy-saving light bulbs ( Bjorklund et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…Many trials have been done for attenuating mercuric chloride toxicity using vitamin E ( Al-Attar, 2011 ), vitamin E in combination with vitamin C ( Muthu and Krishnamoorthy, 2012 ), sodium selenite ( Celikoglu et al., 2015 ), Lactobacillus ( Alhusaini et al., 2021 ). Other studies include zinc alone ( Fukino et al., 2009 ; Oliveira et al., 2014 ), Scorpion venom alone ( Salman et al., 2016 ) and others ( Cappelletti et al., 2019 ; Nabil et al., 2020 ). None of these materials prove complete protection against mercury toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin E and zinc chloride supplement

Shalan

2022

Heliyon

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“…Liver is considered the major target for numerous toxicants such as lead. Environmental and occupational exposure to lead can result in many changes in the architecture of the liver [48]. Autopsy reports of humans exposed to lead indicated that liver is the principal reservoir (33%) of lead, followed by kidneys.…”

Section: Discussionmentioning

confidence: 99%

Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

et al. 2021

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Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone phenolic-rich extracts (MPR and MAPR, respectively) of the N. latifolia fruit (NLF) on lead acetate-induced liver and kidney damaged were assessed in Wistar rats. The antioxidant activities of both phenolic-rich extracts of NLF were also carried out using standard methods. Seven groups of Wistar rats comprising of 5 rats each were used for the study and 1000 mg/kg body weight (bw.) of lead acetate solution was administered orally to the 6 groups of animals to induce liver and kidney damage. The high and low dosages of 300 and of 150 mg/kg body weight (bw.) of both MPR and MAPR were administered orally to four groups for 14 days along positive (100 mg/kg bw. of silymarin), negative (treated with the placebo) and naïve control (non-induced). The percentage DPPH radical scavenging activities, ferric reducing antioxidant power and percentage inhibition of lipid peroxidation show high antioxidants activities dose-dependently. Furthermore, administration of lead acetate significantly (p > 0.05) reduces the weight gain and elevates the liver and kidney relative weight as well as their respective damage biomarkers with distortions in their histologies. However, treatment with MPR and MAPR resulted in significant (p < 0.05) improve in the percentage body weight gain, relative liver and kidney weight as well as restoration of the activities of the liver and kidney functions biomarkers of the treated animals. Likewise, lesser hepatic and renal cells injury were also observed in the treated groups with MAPR being more active at high dosage which significantly (p < 0.05) compared well with normal group. Hence, the phenolics content of the N. latifolia fruit can be exploited further for drug development for the management kidney and liver damage arise from lead-induced toxicity.

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Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Cited by 14 publications

References 34 publications

Toxicological effects of thimerosal on rat kidney: a histological and biochemical study

Toxicological effects of thimerosal on rat kidney: a histological and biochemical study

Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin E and zinc chloride supplement

Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

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