Effects of Qingshen Granules on the Oxidative Stress‐NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats

Jin, Hua; Wang, Yiping; Wang, Dong; Zhang, Lei

doi:10.1155/2018/4761925

Cited by 18 publications

(14 citation statements)

References 26 publications

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“…The activation of NF-ĸB usually promotes the expression of pro-inflammatory markers and apoptosis. The increased production of the inflammatory markers such as TNFα further activates NF-ĸB leading to prolonged and persistent inflammatory response [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…NF-ĸB, a pivotal inflammatory factor is activated in the podocytes, mesangial cells and tubular cells [ 10 ]. Increased expression and activation of NF-ĸB in these cells results in the production of pro-inflammatory factors and eventually apoptosis [ 47 ]. Decreased apoptosis was reported in NFκB tubular epithelial-specific knockout mice due to less activation of NFκB and reduced chemokine expression [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

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Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Alabi

Brooks

Oguntibeju

2021

Plants

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Kidney disease in diabetes is one of the common microvascular complications of diabetes mellitus implicated in end-stage renal failure. This study explored the ability of Anchomanes difformis to ameliorate kidney and pancreatic damage in type 2 diabetes mellitus using male Wistar rats. Two weeks of fructose (10%) administration followed by streptozotocin (40 mg/kg) were used to induce type 2 diabetes. Leaf extract (aqueous) of Anchomanes difformis (200 mg and 400 mg/kgBW) was administered orally for six weeks. Body weights were monitored, urea and creatinine were measured. Interleukins (IL)-1β, IL-6, IL-10, IL-18, and TNFα were measured in the kidney lysate. CAT, SOD, ORAC, FRAP, and MDA levels were also evaluated in the kidney. Transcription factors (Nrf2 and NF-ĸB/p65) and apoptotic markers (Bcl2 and caspase 3) were investigated in the kidney. Histological sections of the pancreas and kidney tissues were examined for any visible pathology. Supplementation with Anchomanesdifformis enhanced antioxidant status, modulated inflammatory response, and reduced apoptosis in the kidney. It also restored the kidney and pancreatic histoarchitecture of the treated diabetic rats. The pathophysiology associated with diabetic nephropathy and pancreatic damage showcase the importance of exploring the use of antidiabetic, nephroprotective agents such as Anchomanes difformis to kidney damage in type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Alabi

Brooks

Oguntibeju

2021

Plants

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“…The study conducted by Jin and his colleagues has demonstrated that the oxidative stress/NF- κ B signal pathway contributed to the formation of unilateral ureteral obstruction renal interstitial fibrosis [ 52 ]. Under hypoxic environment, excessive ROS can activate the NF/ κ B signaling pathway and then promote the expression of HIF-1 α [ 53 ].…”

Section: Contribution Of Oxidative Stress To Hif-1-mediated Profibrotic Changesmentioning

confidence: 99%

Contribution of Oxidative Stress to HIF‐1‐Mediated Profibrotic Changes during the Kidney Damage

Zhang

Wang

2021

Oxidative Medicine and Cellular Longevity

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Hypoxia and oxidative stress are the common causes of various types of kidney injury. During recent years, the studies on hypoxia inducible factor- (HIF-) 1 attract more and more attention, which can not only mediate hypoxia adaptation but also contribute to profibrotic changes. Through analyzing related literatures, we found that oxidative stress can regulate the expression and activity of HIF-1α through some signaling molecules, such as prolyl hydroxylase domain-containing protein (PHD), PI-3K, and microRNA. And oxidative stress can take part in inflammation, epithelial-mesenchymal transition, and extracellular matrix deposition mediated by HIF-1 via interacting with classical NF-κB and TGF-β signaling pathways. Therefore, based on previous literatures, this review summarizes the contribution of oxidative stress to HIF-1-mediated profibrotic changes during the kidney damage, in order to further understand the role of oxidative stress in renal fibrosis.

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“…Glomerular edema results from obstruction in the renal tubules (Zayed et al, 2018), evident by the presence of edematous epithelial lining, intra-tubular cellular debris and intra-tubular hyaline casts in the renal tubules. Redox disturbance is a main causative factor in renal obstruction by hindering fluid outflow (Jin et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of curcumin on the kidney of diclofenac sodium-challenged mice: apoptotic, redox potential and histopathological outcomes

Ragab

Abd-Elkareem

Khalil

et al. 2022

JoBAZ

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Background The renal burden imposed by diclofenac sodium (DS) remedy is a significant concern and limits the extension in its clinical application. Curcumin (Cur) can be used as a promising natural phytochemical in rescuing chemotherapy-associated renal dysfunction owing to its redox stabilizing and cytoprotective nature. Thus, the current experiment aims to highlight the possible ameliorative impact of Cur on DS-induced renal damage and its mediating mechanisms in adult male mice. Methods A total number of eighteen healthy adult mice of the male sex were classified into 3 groups for 21 days. The first group served as a control, whereas the second one received DS at 10 mg/kg body weight by intraperitoneal route of administration daily during the last 14 days of the experiment. The third group was supplemented with Cur at 100 mg/kg body weight during the entire duration of the intervention in conjunction with the DS burden. At the end of the experimental protocol, kidney functions, redox parameters, histopathological investigation and TUNEL assay were performed. Results Cur succeeded in restoring the typical histomorphometric features and reducing the apoptosis in the kidney. The redox disturbances in the kidney of DS-challenged mice rebalanced were manifested by normalizing the level of renal reduced glutathione and immunostaining of glutathione reductase and superoxide dismutase 2. No marked alteration in plasma urea level in the DS group could be noticed compared to the control. Nevertheless, an obvious reduction in plasma urea level was observed in the DS+Cur group relative to the control and DS groups. The comparison between all experimental groups revealed the absence of significant difference in plasma creatinine and renal lipid peroxide levels. Conclusions Cur might exert its renoprotective action through its cytoprotective, anti-apoptotic and antioxidant characteristics. The findings of this study shed light on using natural phytochemicals to alleviate the adverse influences of chemotherapies.

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Effects of Qingshen Granules on the Oxidative Stress‐NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats

Cited by 18 publications

References 26 publications

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes

Contribution of Oxidative Stress to HIF‐1‐Mediated Profibrotic Changes during the Kidney Damage

Protective effect of curcumin on the kidney of diclofenac sodium-challenged mice: apoptotic, redox potential and histopathological outcomes

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