Pancreatic Cancer Incidence and Lethality Rates in Brazil

Souza, Lucila Marieta Perrotta de; Moreira, Jessica P.L.; Fogaça, Homero Soares; Luiz, Ronir Raggio; Souza, Heitor

doi:10.1097/mpa.0000000000000791

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Interestingly, other studies had already identified South and Southeast Brazil as regions with higher frequencies of cancer cases (34,35). Similar to recent ecological studies from our group pertaining to gastric cancer (18) and pancreatic cancer (19), the hospitalization rates were higher in the South and Southeast regions, whereas in the North and Northeast regions, the rates were the lowest in the country. Here, the highest rates of EC were observed in areas of greater economic development, which also have a higher HDI and lower social vulnerability indices (SVIs).…”

Section: Discussionsupporting

confidence: 88%

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Geographic distribution and time trends of esophageal cancer in Brazil from 2005 to 2015

et al. 2019

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The purpose of the present study was to investigate the geographical distribution and time trends of the incidence and lethality of esophageal cancer (EC) in Brazil. The present study conducted an ecological study of EC using records from January 2005 to December 2015 in the Health Informatics Department of the Brazilian Ministry of Health (DATASUS) registry. In addition to demographical data on the population, EC incidence and lethality rates were estimated from hospitalizations and in-hospital mortalities and were adjusted by total available hospital beds. The adjusted EC rates per 100,000 increased from 9.1 in 2005 to 12.1 in 2015. The prevalence among males increased from 69 to 78%, while the female rates remained stable over the same period. Although EC was the most common in South and Southeast Brazil, the rates increased proportionately more in the other regions of the country, especially among males. Geographical analysis revealed higher rates of EC in more urbanized areas, with a coast-to-inland gradient. While rates increased in people older than 50 years, they decreased among people below this age. However, the lethality rates remained stable and high during the study period, overlapping with hospital admission rates. The recent increasing trend in the EC incidence, with shifts from the south towards the north and from more urbanized towards rural areas, suggests that environmental factors are crucial in EC pathogenesis. The concentration of EC in South Brazil may reflect the presence of major environmental factors in association with a possible genetic predisposition. The unchanging high mortality associated with EC in the rapidly aging population suggests that EC will continue to impose a significant social and economic burden in the future.

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Section: Discussionsupporting

confidence: 88%

“…Data source. The study methods have been described in similar previous studies from our group elsewhere (18,19). Data from the Health Informatics Department of the Brazilian Ministry of Health (DATASUS) (http://www2.datasus.gov.…”

Section: Methodsmentioning

confidence: 99%

Geographic distribution and time trends of esophageal cancer in Brazil from 2005 to 2015

et al. 2019

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“…Previous epidemiological studies performed in developed countries have demonstrated a significant increase in the incidence of pancreatic cancer . Similarly, data from government‐sponsored databases in Brazil point to a nearly twofold increase in the incidence of pancreatic cancer over the last decade . While this may stem from improvements in our country’s notification systems, the upward trends in the number of new pancreatic cancer cases seen in our institution ratify the findings of population‐based studies.…”

Section: Discussionsupporting

confidence: 85%

“…Also, they may underestimate the consequences of the disease in the studied populations, even in small countries with organized cancer databases . In Brazil, there is limited information on the epidemiological burden of pancreatic cancer and national cancer databases sponsored by the government suffer from significant problems, such as underreporting of incident cases and deaths . Therefore, other sources of information should be explored to better understand the population of patients treated for pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinico‐pathological features and survival of patients with malignant exocrine pancreatic neoplasms: The AC Camargo Cancer Center experience

Jesus

Camandaroba

Donadio

et al. 2018

Journal of Surgical Oncology

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Background: Pancreatic cancer plays an important role in cancer-related mortality.Few studies have been performed in Brazil to characterize patients affected by this disease. We aimed to describe the clinico-pathological characteristics and the survival of patients with pancreatic cancer seen at AC Camargo Cancer Center (ACCCC). Methods:We included patients ≥ 18-year old, with a histologically confirmed diagnosis of exocrine pancreatic cancer, that attended at least one visit at ACCCC from 2008 to 2016. Results:The study included 739 patients. Median age at diagnosis was 64 years. Most patients were male. About 5% presented a family history of pancreatic cancer. A total of 40% had diabetes and 51.4% presented with ECOG performance status 1. Tumors most often arose in the pancreatic head and roughly half of the patients had metastatic disease at presentation. Median overall survival of patients with potentially resectable disease submitted to surgery at ACCCC was 35.4 months.Median overall survival times of patients with the unresectable and metastatic disease were 14.1 and 9.3 months, respectively. Conclusions:The features of our population match those of studies done in developed countries. We believe multicentric data from patients with pancreatic cancer in Brazil could enable more effective preventive and therapeutic approaches to the disease. K E Y W O R D S cancer, epidemiology, features, outcomes, pancreas 1 | INTRODUCTION Pancreatic cancer represents an important cause of cancer-related morbidity and mortality. In 2015, pancreatic cancer was ranked 13thin cancer incidence worldwide. 1 In the same year, it was the 7th most common cause of cancer-related death, with 412 000 estimated deaths. Moreover, studies performed in developed countries have shown an upward trend in both incidence and mortality rates, and it J Surg Oncol. 2019;119:71-78.wileyonlinelibrary.com/journal/jso

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“…7 The number of hospitalizations due to pancreatic cancer (not the incidence rate) within the Brazilian National Health System doubled from 2005 to 2012 for both sexes, from 2.4/100,000 to 4.5/100,000, with the highest increase in the states of the northeastern region. 8 The importance of this demonstration of the increase in the burden of pancreatic cancer is that there are no detectable risk factors for this neoplasm. 9 People with pancreatic cancer have not benefited from recent improvements in overall survival relating to genetic profiling ("precision medicine"), 10 and no screening tool has been proven to be effective for early diagnosis of pancreatic cancer.…”

mentioning

confidence: 98%

The burden of pancreatic cancer is rising in Brazil

Lotufo

2019

Sao Paulo Med. J.

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Pancreatic Cancer Incidence and Lethality Rates in Brazil

Cited by 17 publications

References 22 publications

Geographic distribution and time trends of esophageal cancer in Brazil from 2005 to 2015

Geographic distribution and time trends of esophageal cancer in Brazil from 2005 to 2015

Clinico‐pathological features and survival of patients with malignant exocrine pancreatic neoplasms: The AC Camargo Cancer Center experience

The burden of pancreatic cancer is rising in Brazil

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