Construction of near infrared light triggered nanodumbbell for cancer photodynamic therapy

Hou, Beibei; Zheng, Bin; Yang, Wenjun; Dong, Chunhong; Wang, Hanjie

doi:10.1016/j.jcis.2017.01.053

Cited by 28 publications

(11 citation statements)

References 33 publications

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“…The peptide-labeled nanoparticles showed a lower cytotoxicity and increased the cellular uptake. At the same time they were efficient killing the cancer cells after light irradiation [75].…”

Section: Carriers Based On Lipidsmentioning

confidence: 90%

The Dark Side: Photosensitizer Prodrugs

2019

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Photodynamic therapy (PDT) and photodiagnosis (PD) are essential approaches in the field of biophotonics. Ideally, both modalities require the selective sensitization of the targeted disease in order to avoid undesired phenomena such as the destruction of healthy tissue, skin photosensitization, or mistaken diagnosis. To a large extent, the occurrence of these incidents can be attributed to “background” accumulation in non-target tissue. Therefore, an ideal photoactive compound should be optically silent in the absence of disease, but bright in its presence. Such requirements can be fulfilled using innovative prodrug strategies targeting disease-associated alterations. Here we will summarize the elaboration, characterization, and evaluation of approaches using polymeric photosensitizer prodrugs, nanoparticles, micelles, and porphysomes. Finally, we will discuss the use of 5-aminolevulinc acid and its derivatives that are selectively transformed in neoplastic cells into photoactive protoporphyrin IX.

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Section: Carriers Based On Lipidsmentioning

confidence: 90%

The Dark Side: Photosensitizer Prodrugs

2019

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“…Short synthetic peptides, such as Arg-Gly-Asp (RGD) [22,23,24], Arg-Glu-Asp-Val (REDV) [25,26,27,28,29,30], and Cys-Ala-Gly (CAG) [31,32], can adhere to ECs and exhibit advantages for rapid endothelialization of biomaterial surfaces [33,34]. The RGD peptide has been widely used as a cell identification site [35,36].…”

Section: Introductionmentioning

confidence: 99%

CAGW Peptide Modified Biodegradable Cationic Copolymer for Effective Gene Delivery

Duo

Wang

et al. 2017

Polymers

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In recent years, gene therapy has become a promising technology to enhance endothelialization of artificial vascular grafts. The ideal gene therapy requires a gene carrier with low cytotoxicity and high transfection efficiency. In this paper, we prepared a biodegradable cationic copolymer poly(d,l-lactide-co-glycolide)-graft-PEI (PLGA-g-PEI), grafted Cys-Ala-Gly-Trp (CAGW) peptide onto this copolymer via the thiol-ene Click-reaction, and then prepared micelles by a self-assembly method. pEGFP-ZNF580 plasmids (pDNA) were condensed by these micelles via electrostatic interaction to form gene complexes. The CAGW peptide enables these gene complexes with special recognition for endothelial cells, which could enhance their transfection. As a gene carrier system, the PLGA-g-PEI-g-CAGW/pDNA gene complexes were evaluated and the results showed that they had suitable diameter and zeta potential for cellular uptake, and exhibited low cytotoxicity and high transfection efficiency for EA.hy926 cells.

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“…The results of ROS production test and PDT test in Hela cells suggested that this nanodumbbell could provide a new NIR diagnosis and treatment nanoplatform. 125 In 2017, Wang et al linked a water-soluble NIR NPs NaYF 4 :Yb 3þ , Tm 3þ to NH 2 -terminated PAMAM dendrimers (G 4 ) and chlorine6 (Ce6) by a layer-by-layer absorption method. 126 The singlet oxygen is generated by Ce6, and the accumulation of singlet oxygen in human breast cancer cells can be regulated by changing the excitation time.…”

Section: Treatmentmentioning

confidence: 99%

“…Cell imaging and photodynamic therapy based on upconverting technologyZnPc loaded-UCN@lipid@PS NPsCell imaging PDTCell killed A schematic illustration shows applications of the triple-layer nanoparticles as NIR remote controlled-release nanocarriers for cell imaging and photodynamic therapy. Reproduced with permission from Hou et al125 Copyright 2017 Elsevier.…”

mentioning

confidence: 99%

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

et al. 2020

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Rare earth-doped nanoparticles have been widely used in disease diagnosis, drug delivery, tumor therapy, and bioimaging. Among various bioimaging methods, the fluorescence imaging technology based on the rare earth-doped nanoparticles can visually display the cell activity and lesion evolution in living animals, which is a powerful tool in biological technology and has being widely applied in medical and biological fields. Especially in the band of near infrared (700–1700 nm), the emissions show the characteristics of deep penetration due to low absorption, low photon scattering, and low autofluorescence interference. Furthermore, the rare earth-doped nanoparticles can be endowed with the water solubility, biocompatibility, drug-loading ability, and the targeting ability for different tumors by surface functionalization. This confirms its potential in the cancer diagnosis and treatment. In this review, we summarized the recent progress in the application of rare earth-doped nanoparticles in the field of bioimaging and tumor treatment. The luminescent mechanism, properties, and structure design were also discussed.

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Construction of near infrared light triggered nanodumbbell for cancer photodynamic therapy

Cited by 28 publications

References 33 publications

The Dark Side: Photosensitizer Prodrugs

The Dark Side: Photosensitizer Prodrugs

CAGW Peptide Modified Biodegradable Cationic Copolymer for Effective Gene Delivery

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

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