Analysis of Lipoprotein Subfractions in 920 Patients With and Without Type 2 Diabetes

Zhao, Xiaoyan; Zhang, Huiwen; Zhang, Yan; Li, Sha; Xu, Rui‐Xia; Sun, Jing; Zhu, Cheng‐Gang; Wu, Na‐Qiong; Gao, Ying; Guo, Yuan‐Lin; Li, Geng; Dong, Qian; Li, Jianjun

doi:10.1016/j.hlc.2016.10.020

Cited by 14 publications

(14 citation statements)

References 21 publications

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“…Although we found that LDL size and large LDL particles were inversely associated with risk of T2D development, we did not nd a strong association between small LDL particles and incident T2D. Hence, a smaller LDL size may be associated more robustly with T2D development [9,10,23,25,33] than absolute concentrations of small LDLP. In comparison, of conventional (apo)lipoprotein and lipid measures, the plasma triglyceride concentration was the only variable that was associated with incident T2D in multivariable analysis in the whole study population at risk.…”

Section: Discussioncontrasting

confidence: 74%

“…Mean TRL and LDL size were calculated using the weighted averages derived from the sum of the diameters of each subfraction. Estimated ranges of particle diameter for the TRL and LDL subfractions were as follows: very large TRLP, 90-240 nm; large TRLP, 50-89 nm; medium TRLP, 37-49 nm; small TRLP, [30][31][32][33][34][35][36]…”

Section: Clinical and Laboratory Measurementmentioning

confidence: 99%

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Triglyceride-Rich Lipoprotein and LDL Particle Subfractions and Their Association With Incident Type 2 Diabetes: The PREVEND Study.

Sokooti

Flores‐Guerrero

Heerspink

et al. 2021

Preprint

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Background: Triglyceride-rich lipoproteins particles (TRLP) and low density lipoprotein particles (LDLP) vary in size. Their association with β-cell function is not well described. We determined associations of TRLP and LDLP subfractions with β-cell function, and evaluated their associations with incident T2D in the general population.Methods: We included 4818 subjects of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study without T2D at baseline. TRLP and LDLP subfraction concentrations and their average sizes were measured using the LP4 algorithm of the Vantera nuclear magnetic resonance platform. HOMA-IR was used as measure of insulin resistance. HOMA-β was used as a proxy of β-cell function.Results: In subjects without T2D at baseline, very large TRLP, large LDLP and LDL size were inversely associated with HOMA-β, whereas large TRLP, medium TRLP and TRL size were positively associated with HOMA-β taking account of HOMA-IR. During a median follow-up of 7.3 years, 263 individuals developed T2D. In multivariable-adjusted Cox regression models, higher concentrations of total, very large, large, and very small TRLP and TRL size were associated with an increased T2D risk after adjustment for relevant covariates, including age, sex, BMI, HDL-C, HOMA-β, and HOMA-IR. On the contrary, higher concentrations of large LDLP and LDL size were associated with a lower risk of developing T2D.Conclusions: Specific TRL and LDL particle characteristics are associated with β-cell function taking account of HOMA-IR. Moreover, TRL and LDL particle characteristics are differently associated with incident T2D, even when taking account of HOMA-β and HOMA-IR.

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Section: Discussioncontrasting

confidence: 74%

Section: Clinical and Laboratory Measurementmentioning

confidence: 99%

Triglyceride-Rich Lipoprotein and LDL Particle Subfractions and Their Association With Incident Type 2 Diabetes: The PREVEND Study.

Sokooti

Flores‐Guerrero

Heerspink

et al. 2021

Preprint

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“…Similar to SAXS and DLS results, the LDL size analyzed by Lipoprint system did not show differences between groups during follow-up time. Xhao et al 45 described that DM2 patients have smaller LDL size than non-DM2 individuals. Regarding that in our study all groups had DM2, however, in their study, the control patients were non-diabetic.…”

Section: Resultsmentioning

confidence: 99%

Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

Lotfollahi

Mello

Costa

et al. 2020

Sci Rep

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The aim of this study was to investigate the effects of 6-months consumption of green-banana biomass on the LDL particle functionality in subjects with type 2 diabetes. Subjects (n = 39, mean age 65 years old) of both sexes with diabetes (HbA1c ≥ 6·5%) were randomized to receive nutritional support plus green-banana biomass (40 g) (n = 21) or diet alone (n = 18) for 6-months. Non-linear optical responses of LDL solutions from these participants were studied by Z-scan technique. UV–visible spectrophotometer was used to measure the absorbance of the LDL samples. Small Angle X-ray Scattering and Dynamic Light Scattering experiments were used to look for any structural changes in LDL samples and to determine their size distribution. The Lipoprint test was used to determine the LDL sub-fractions in terms of distribution and size. Consumption of green-banana biomass, reduced total- ( p = 0.010), non-HDL-cholesterol ( p = 0.043), glucose ( p = 0.028) and HbA1c ( p = 0.0007), and also improved the protection of the LDL particle against oxidation, by the increase in carotenoids content in the particles ( p = 0.007). This higher protection against modifications may decrease the risk of developing cardiovascular disease. These benefits of the green-banana biomass encourage the use of resistant starches with potential clinical applications in individuals with pre-diabetes and diabetes.

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“…An analysis of lipoprotein subfractions in 920 patients with and without type 2 diabetes confirmed the increase in concentration and size of smaller LDL particles. 121 …”

Section: Triglyceride and Cholesterol Absorption In Diabetesmentioning

confidence: 99%

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Tomkin¹,

Owens²

2017

DMSO

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Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the relationship among the disturbances in glucose, lipid, and bile salt metabolic pathways that occur in diabetes. In particular, excess nutrient intake and starvation have major metabolic effects, which have allowed us new insights into the disturbance that occurs in diabetes. Metabolic regulators such as the forkhead transcription factors, the farnesyl X transcription factors, and the fibroblast growth factors have become important players in our understanding of the dysregulation of metabolism in diabetes and overnutrition. The disturbed regulation of lipoprotein metabolism in both the intestine and the liver has been more clearly defined over the past few years, and the atherogenicity of the triglyceride-rich lipoproteins, and – in tandem – low levels of high-density lipoproteins, is seen now as very important. New information on the apolipoproteins that control lipoprotein lipase activity has been obtained. This is an exciting time in the battle to defeat diabetic atherosclerosis.

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Analysis of Lipoprotein Subfractions in 920 Patients With and Without Type 2 Diabetes

Cited by 14 publications

References 21 publications

Triglyceride-Rich Lipoprotein and LDL Particle Subfractions and Their Association With Incident Type 2 Diabetes: The PREVEND Study.

Triglyceride-Rich Lipoprotein and LDL Particle Subfractions and Their Association With Incident Type 2 Diabetes: The PREVEND Study.

Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

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