Clinicopathological characteristics of biliary neuroendocrine neoplasms: a multicenter study

Lee, Kyong Joo; Cho, Jae Hee; Lee, Sang Hyub; Lee, Kwang Hyuk; Park, Byung Kyu; Woo, Sang Myung; Ryu, Ji Kon; Lee, Jong Kyun; Kim, Yeon Suk; Kim, Jae Woo; Lee, Woojin

doi:10.1080/00365521.2016.1261938

Cited by 26 publications

(30 citation statements)

References 24 publications

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“…12,14,20 Some studies found more female patients in their cohorts, 10,12,20 however, other studies including ours showed no clear female tendency. 11,13,14 Most of the cases in our study had no specific clinical presentation, in accordance with most previous literatures, [12][13][14] however, functional neuroendocrine tumors of gallbladder were also reported, including causing hyperinsulinemia, paraneoplastic sensory neuropathy and Cushing's syndrome. [23][24][25] Since no specific characteristics can be used to identify GB-NEC, all 15 cases were treated as patients with gallbladder adenocarcinoma in the beginning.…”

Section: Discussionsupporting

confidence: 90%

“…4,9,19 Due to its rarity, studies of GB-NEC are mostly case reports and only a few studies were single-center researches with small samples. 11,[13][14][15]20 Therefore, the data to evaluate the clinicopathological characteristics are limited. In our study, 15 patients with GB-NEC from two well-known tertiary medical centers were included, which makes it one of the largest series of GB-NEC in China.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, once diagnosed, extensive surgery and careful follow-up are mandatory and radical surgical resection is thought to be the relatively optimal treatment while medical therapy will be favorable in high grade metastatic carcinomas. [10][11][12][13] However, current treatment strategies cannot prevent patients from poor prognosis and overall survival time varied from 4 to 13.7 months, 11,14,15 which was significantly worse than gallbladder adenocarcinoma (GB-ADC), the most common carcinoma of gallbladder. In this report, we introduced and analyzed 15 patients with gallbladder neuroendocrine carcinoma (GB-NEC) treated in two tertiary medical centers in The People's Republic of China between 2009 and 2015, then we compared them with patients of GB-ADC using a propensity score analysis and discussed their clinicopathological features and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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<p>Clinical Analysis of 15 Cases of Gallbladder Neuroendocrine Carcinoma and Comparison with Gallbladder Adenocarcinoma Using a Propensity Score Matching</p>

Yan¹,

Wang²,

Xiao³

et al. 2020

CMAR

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This study aimed to investigate the clinicopathological features and prognosis of gallbladder neuroendocrine carcinoma (GB-NEC). Patients and Methods: Fifteen patients with GB-NEC and 171 patients with gallbladder adenocarcinoma (GB-ADC) treated in two tertiary medical centers between 2009 and 2015 were included. The clinicopathological features and prognostic risk factors of GB-NEC were analyzed retrospectively. A propensity score matching in a 1:2 ratio was used to compare the prognosis of GB-NEC and GB-ADC. Results: For patients with GB-NEC, the median age of patients was 58.4 years (range 26-75), with a M:F ratio of 7:8. Based on 2010 WHO classification, ten cases were pathologically confirmed as NECs and five cases as MANECs. For TNM staging, eleven patients were stage III or above; while for Nevin staging, seven patients were stage IVor above. The 1-, 2-, and 3-year overall survival (OS) of GB-NEC were 60.0%, 38.8% and 31.1%, respectively, and the median survival time was 20.4 months. Patients with lymph node metastasis had significantly shorter survival than those without (OS: 10.4 vs 26.0 months, p<0.05). Accordingly, patients of Nevin stage III had better OS than those of Nevin stage IV (p<0.05), but other potential risk factors including gender, age, clinical symptoms, TNM stage, histopathologic subtype and treatment showed no significance. After the propensity score matching, the baseline variables had no significant difference between 15 patients with GB-NEC and 30 patients with GB-ADC, survival analysis showed GB-NEC had worse prognosis (3-year overall survival rate: 31.1% vs 63.8%, p<0.01). Conclusion: Nevin staging helps classify patients of GB-NEC with different prognosis and the lymph node metastasis is a strong negative prognostic factor for OS. The propensity score analysis revealed even with the similar stage and treatment, GB-NEC still had worse OS than GB-ADC.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Clinical Analysis of 15 Cases of Gallbladder Neuroendocrine Carcinoma and Comparison with Gallbladder Adenocarcinoma Using a Propensity Score Matching</p>

Yan¹,

Wang²,

Xiao³

et al. 2020

CMAR

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“…A multicenter study assessed the clinicopathological features, therapeutic approaches, and prognosis of as much as 43 biliary NET patients, but the optimal treatment and prognoses were still not well established. [ 5 ] The treatment of the NEC referred to the treatment of gallbladder cancers in clinical practice. However, for the stage of T 1b N 0 M 0 gallbladder cancer, there are also many controversies about the surgical strategy.…”

Section: Discussionmentioning

confidence: 99%

Cholecystectomy with gallbladder bed cautery might be sufficient for T1bN0M0 neuroendocrine carcinoma of gallbladders

Liu

Chen

et al. 2017

Medicine

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Introduction:Neuroendocrine carcinoma was a rare kind tumor in gallbladders. So far, there is no consensus of treatment of the gallbladder neuroendocrine carcinoma.Case presentation:Three patients, 1 male and 2 females, were admitted in our hospital because of right upper quadrant pain. No one complained fever, jaundice, weight loss, or carcinoid syndrome-related symptoms such as diarrhea, flushing, edema, and wheezing. The MRI detected the broad base of gallbladder tumors. However, they refused any radical surgery. We performed a laparoscopic cholecystectomy with gallbladder bed cautery. The pathology results showed that 2 cases were mixed neuroendocrine carcinoma (NECs), and 1 case was a simple NEC. Chromogranin A and synaptophysin were positive in all cases. The pathological TNM stages of all patients were in the T1bN0M0 stage. The range of Ki-67 was from 40% to 80%. During the at least 26 months’ follow-up, there is no case with the recurrence of the carcinoma without any chemotherapy or radiotherapy.Conclusions:Cholecystectomy with gallbladder bed cautery might be enough for treatment of T1bN0M0 gallbladder neuroendocrine carcinoma.

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“…50-70% of neuroendocrine neoplasms of the ampulla of Vater are well-differentiated NENs (G1 and G2), unlike neuroendocrine neoplasms of the gallbladder, 90-100% of which are neuroendocrine cancers (G3) [15,16].…”

Section: Neuroendocrine Neoplasms Of the Duodenummentioning

confidence: 99%

Nowotwory neuroendokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma (zasady postępowania rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Lipiński¹,

Rydzewska²,

Fołtyn³

et al. 2017

Endokrynologia Polska

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Clinicopathological characteristics of biliary neuroendocrine neoplasms: a multicenter study

Abstract: The 2010 World Health Organization classification of neuroendocrine carcinoma G3 was the only factor related to poor prognosis in patients with biliary neuroendocrine neoplasms.

Cited by 26 publications

References 24 publications

<p>Clinical Analysis of 15 Cases of Gallbladder Neuroendocrine Carcinoma and Comparison with Gallbladder Adenocarcinoma Using a Propensity Score Matching</p>

<p>Clinical Analysis of 15 Cases of Gallbladder Neuroendocrine Carcinoma and Comparison with Gallbladder Adenocarcinoma Using a Propensity Score Matching</p>

Cholecystectomy with gallbladder bed cautery might be sufficient for T1bN0M0 neuroendocrine carcinoma of gallbladders

Nowotwory neuroendokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma (zasady postępowania rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

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