Cholecystectomy with gallbladder bed cautery might be sufficient for T1bN0M0 neuroendocrine carcinoma of gallbladders

Liu, Wei; Chen, Weijie; He, Xiaodong; Qu, Qiang; Hong, Tao; Li, Binglu

doi:10.1097/md.0000000000008778

Cited by 15 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the presence of lymph node metastasis around the gallbladder and retroperitoneum is difficult to distinguish from the other gallbladder tumors (30). Imaging examinations provide significant results only when used at an early stage and then provide aid in establishing a treatment plan (31).…”

Section: Diagnosismentioning

confidence: 99%

Neuroendocrine tumors of the gallbladder (Review)

et al. 2020

View full text Add to dashboard Cite

A gallbladder neuroendocrine neoplasm (GB-NEN) is a unique heterogeneous neoplasm, originating from neuroendocrine cells and able to secrete peptides as its neurotransmitter. Among all the neuroendocrine tumors (NETs), the GB-NEN prevalence is 0.5%, which accounts for ~2.1% of all gallbladder tumors. The current study aimed to present an up-to-date review of the clinical features, diagnosis and treatment of NETs of the gallbladder. A systematic literature search was performed in order to identify all relevant studies published. Thus far, the etiology and pathogenesis of GB-NEN remains unclear. Moreover, an ambiguous clinical manifestation exists as observed during laboratory examinations. As GB-NEN is a rare gallbladder lesion and is seldom seen in clinical practice, there is a limited availability of review reports, and it is therefore often considered only as a case study. It is difficult to distinguish GB-NEN from other gallbladder diseases using imaging diagnostic techniques. Although chemotherapy treatment provides prolonged progression-free survival, surgery is considered the best option. Thus, to overcome the inherent risks or shortfalls of traditional surgery; early detection, diagnosis and treatment of GB-NEN are required to improve patient longevity.

show abstract

Section: Diagnosismentioning

confidence: 99%

Neuroendocrine tumors of the gallbladder (Review)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Compared with conventional laparotomy, our department found that laparoscopic surgery for gallbladder carcinomas may provide comparable perioperative outcomes and it is helpful for less intraoperative bleeding, shorter postoperative days of oral diet recovery and hospital stays [6]. In the study performed by Liu et al, all three patients with GB-NEC at T1bN0M0 stage underwent laparoscopic cholecystectomy with gallbladder bed cautery, and no recurrences were found during the at least 26.0 months' follow-up without any postoperative chemotherapy or radiotherapy (Table 3) [7]. However, there are few reports discussing laparoscopic surgery for GB-NECs at advanced stages.…”

Section: Discussionmentioning

confidence: 96%

Laparoscopic Surgery for Gallbladder Neuroendocrine Carcinoma: a Case Series and Literature Review

et al. 2021

View full text Add to dashboard Cite

Background: Gallbladder neuroendocrine carcinomas (GB-NECs) are a group of rare and heterogeneous neoplasms. There are few reports regarding laparoscopic surgery for GB-NEC cases diagnosed at advanced stage.Case presentation: Three patients, two females and one male, were admitted to our hospital. Two patients had the chief complaint of upper quadrant pain and one patient was found to have gallbladder occupation during a routine health checkup. No patient complained jaundice, weight loss, or carcinoid syndrome-related symptoms including diarrhea, edema, flushing and wheezing. Contrast-enhanced computed tomography (CT) examination showed local wall thickening of the gallbladder. In addition, one patient showed focal liver parenchymal invasion, and none of the three patients' preoperative imaging examination revealed lymph nodes (LNs) metastases. All three patients underwent laparoscopic radical cholecystectomy according to intraoperative frozen pathological examination, and they were diagnosed as GB-NEC based on postoperative pathology and immunohistochemistry. TNM stages of these patients were A (T3N0M0), B (T3N1M0) and B (T3N2M0), respectively. Chromogranin A (CgA) and synaptophysin (Syn) were positive in all cases. No patient encountered postoperative bleeding, bile leakage, abdominal abscess, gastrointestinal stulas or pulmonary complication. Two patients underwent postoperative chemotherapy with two cycles and seven cycles of etoposide plus cisplatin, respectively. Another patient did not receive postoperative chemotherapy due to his poor general condition. The overall survival time of three patients was 4.6 months, 16.8 months and 8.5 months, respectively. All three patients presented with liver and/or bile duct recurrence after surgery with the tumor-free survival time of 2.3 months, 3.3 months and 3.0 months, respectively.Conclusion: Laparoscopic surgery may be considered as a potential treatment for advanced GB-NEC in selected patients.However, further studies are needed to investigate the tumor-free survival bene t of laparoscopic surgery, and whether expanding the resection scope could reduce postoperative recurrence.

show abstract

“…[ 21 ] It has been reported that simple cholecystectomy is enough for in situ GB-NENs and those of T1N0M0 stage. [ 4 ] In the study performed by Liu et al, [ 22 ] all 3 GB-NEC patients who were in T1bN0M0 stage underwent laparoscopic cholecystectomy with gallbladder bed cautery, and no recurrences were found without any chemotherapy or radiotherapy during the follow-up period of at least 26 months. For those who are diagnosed at more advanced stage without distant metastasis, radical cholecystectomy is the preferred treatment if it is available.…”

Section: Discussionmentioning

confidence: 99%

Gallbladder neuroendocrine carcinoma

et al. 2020

View full text Add to dashboard Cite

Gallbladder neuroendocrine carcinoma (GB-NEC) is a group of rare and heterogeneous neoplasms and there are few reports at present. We analyzed the clinical and pathological features of 7 patients with GB-NEC who were admitted to Zhejiang Provincial People's Hospital from January 2011 to October 2019. The median age of 7 patients was 58 years with male to female ratio of 1:2.5. Right upper quadrant discomfort was the main complaint and no patients presented carcinoid syndrome-related symptoms. In contrast-enhanced computed tomography (CT) examination, 5 of 6 patients showed well-defined margin and continuous thin line-like contrast enhancement on the mucosa. Among the patients with liver metastases before surgery, 66.7% of patients were cancer antigen 125 (CA-125) positive, and among the patients presented with liver metastases during follow-up period, all patients were CA-125 positive. All patients with elevated CA-125 did not have ascites, ovarian carcinoma, peritoneal carcinoma, and endometrial carcinoma. According to postoperative pathological report, 1 patient was stage IIIA, and the other 6 patients were stage IVB. Six patients underwent surgery, and 1 patient just underwent liver biopsy. Two patients underwent laparoscopic radical cholecystectomy, and neither of them encountered serious complications after surgery with the overall survival time of 4.6 and 16.8 months, respectively. Compared with the patients without chemotherapy, 3 patients postoperatively treated with chemotherapy lived longer. The median survival of all 7 patients was 4.6 months and the 1-, 2-year survival rates were 14.29%, 0%. Surgical resection, including laparoscopic radical cholecystectomy, is feasible for the treatment of advanced GB-NEC in selected patients and has the advantages of prolonging survival in combination with chemotherapy. The elevation of CA-125 can be utilized as an important predictor of poor prognosis, while more investigations are necessary to confirm it.

show abstract

Cholecystectomy with gallbladder bed cautery might be sufficient for T1bN0M0 neuroendocrine carcinoma of gallbladders

Cited by 15 publications

References 10 publications

Neuroendocrine tumors of the gallbladder (Review)

Neuroendocrine tumors of the gallbladder (Review)

Laparoscopic Surgery for Gallbladder Neuroendocrine Carcinoma: a Case Series and Literature Review

Gallbladder neuroendocrine carcinoma

Contact Info

Product

Resources

About