Measuring Oxidative DNA Damage With 8-Hydroxy-2’-Deoxyguanosine Levels in Patients With Laryngeal Cancer

Mazlumoglu, Muhammet Recai; Özkan, Özalkan; Hakan, Hamit; Özyıldırım, Ercan; Bingöl, Fatih; Yörük, Özgür; Kuduban, Ozan

doi:10.1177/0003489416675873

Cited by 17 publications

(15 citation statements)

References 31 publications

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“…Increased levels of DNA by-products expressed during oxidative stress such as 8-OHdG have been demonstrated in various tumors. [8][9][10]16] Kumar et al [10] found saliva 8-OHdG levels 1.6-fold higher in patients with SCC of the head and neck then in control subjects. Kaur et al [17] compared saliva 8-OHdG levels between patients with oral precancerous lesions, cancer and a control group of healthy age-and gender-matched individuals.…”

Section: Discussionmentioning

confidence: 99%

“…It is reported to be increased with different cancers. [8][9][10] Lipid peroxidation caused by free radicals is an important pathological process involving the oxidation of polyunsaturated fatty acids in biological membranes. [11] Oxidative stress through lipid peroxidation is considered to play an important role in the development of multiple diseases including carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

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An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Çetin¹,

Düzenli²,

Berköz³

et al. 2020

ENT Updates

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Objective: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F 2α (8-iso-PGF 2α) are indicators of oxidative stress in the human body. The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF 2α levels in patients with larynx carcinoma and to compare them with healthy controls. Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELI-SA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF 2α levels. TNM stages of the patients were recorded from the patient records in the study group. Results: 8-OHdG and 8-iso-PGF 2α levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group. Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF 2α levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Çetin¹,

Düzenli²,

Berköz³

et al. 2020

ENT Updates

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show abstract

“…Because of a possible increase in 8-OHDG levels in stored blood can cause gene mutations and false protein coding after blood transfusion, it is important to prevent injury in the DNA bases. Increasing oxidative stress and decreasing antioxidant capacity due to storage time (3,9,15,17,26), especially OH . radicals, can lead to DNA oxidation by damaging nuclear proteins and DNA (9).…”

Section: Discussionmentioning

confidence: 99%

“…Increasing oxidative stress and decreasing antioxidant capacity due to storage time (3,9,15,17,26), especially OH . radicals, can lead to DNA oxidation by damaging nuclear proteins and DNA (9). Because of a possible increase in 8-OHDG levels in stored blood can cause gene mutations and false protein coding after blood transfusion, it is important to prevent injury in the DNA bases (41).…”

Section: Discussionmentioning

confidence: 99%

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Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Huyut¹,

Şekeroğlu²,

Hakan³

et al. 2018

Eastern J Med

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Identification of novel factors that affect the onset of idiopathic chronic pancreatitis: The role for microRNA‐323b‐5p

Sun¹,

Liu

An³

et al. 2022

The Journal of Gene Medicine

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Background The c.194+2 T>C variant of serine protease inhibitor Kazal type 1 (SPINK1) is a known genetic risk factor found in Chinese patients with idiopathic chronic pancreatitis (ICP), but the early‐onset mechanisms of ICP are still unclear. Methods Complementary experimental approaches were used to pursue other potential pathologies in the present study. The serum level of SPINK1 of ICP patients in the Han population in China was detected and verified by an enzyme‐linked immunosorbent assay. Next, differentially expressed proteins and microRNAs from plasma samples of early‐onset and late‐onset ICP patients were screened by proteomic analysis and microarray, respectively. Results Combined with these advanced methods, the data strongly suggest that the regulatory effects of microRNAs were involved in the early‐onset mechanism of the ICP by in vitro experiments. There was no significant difference in the plasma SPINK1 expression between the early‐onset ICP and the late‐onset patients. However, the expression of plasma glutathione peroxidase (GPx3) in early‐onset ICP patients was markedly lower than that in late‐onset ICP patients, although the level of hsa‐miR‐323b‐5p was lower in late‐onset patients compared to the early‐onset ICP group. In vitro experiments confirmed that hsa‐miR‐323b‐5p could increase apoptosis in caerulein‐treated pancreatic acinar cells and inhibit the expression of GPx3. Conclusions The up‐regulated hsa‐miR‐323b‐5p might play a crucial role in the early‐onset mechanisms of ICP by diminishing the antioxidant activity through the down‐regulation of GPx3.

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Measuring Oxidative DNA Damage With 8-Hydroxy-2’-Deoxyguanosine Levels in Patients With Laryngeal Cancer

Cited by 17 publications

References 31 publications

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Identification of novel factors that affect the onset of idiopathic chronic pancreatitis: The role for microRNA‐323b‐5p

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