Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Huyut, Zübeyir; Şekeroğlu, Mehmet Ramazan; Hakan, Hamit; Balahoroğlu, Ragıp; Çokluk, Erdem

doi:10.5505/ejm.2018.94834

Cited by 2 publications

(3 citation statements)

References 33 publications

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“…The scale bar is 100 µm for all images. The stars show that the immunoreactivity is more pronounced than the arrowheads and arrows (Huyut et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

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Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

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Testicular dysfunction is one of the serious side effects of cytotoxic chemotherapy. It has been reported that low sexual function and quality of life and infertility concerns associated with gonadal insufficiency in young patients are related to psychosocial distress (Levi et al., 2015). Doxorubicin (DOX, brand name Adriamycin), which is one of the most important cornerstones of many chemotherapeutic protocols, is an anticancer drug selected in the treatment of many chemo-responsive tumours from ovarian, breast, liver and lung cancer and lymphomas. However, DOX can cause severe dose-dependent toxicity for other nontarget tissues, including testicular tissues (e.g. reduced testicular weight; Nishi et al., 2018). Studies have reported that DOX toxicity causes testicular damage and apoptosis and adversely affects reproductive function (Kopalli et al., 2016; Nowrouzi et al., 2019). In addition, DOX has been reported to increase oxidative stress by reducing antioxidant capacity in testicular tissue (Uyeturk et al., 2014). Does DOX cause testicular toxicity by only increasing oxidative stress and apoptosis? Or does DOX have an effect on testicular

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“…The scale bar is 100 µm for all images. The stars show that the immunoreactivity is more pronounced than the arrowheads and arrows (Huyut et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

“…CoQ10, also known as ubiquinone and widely used as a food supplement, is an energising antioxidant and mitochondrial membrane component. CoQ10 is a component of the seminal fluid and increases sperm function (Huyut et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

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“…Other antioxidants, including uric acid, resveratrol, or quercetin, have also been studied to improve quality of stored RBCs. However, these antioxidants have not been included in commercial RBC additive solution formulations, yet [38][39][40] . Unlike the RBC additive solutions, antioxidants have been featured in various commercially available storage mediums 41 .…”

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confidence: 99%

Extended supercooled storage of red blood cells

Isiksacan,

William,

Senturk

et al. 2024

Commun Biol

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Red blood cell (RBC) transfusions facilitate many life-saving acute and chronic interventions. Transfusions are enabled through the gold-standard hypothermic storage of RBCs. Today, the demand for RBC units is unfulfilled, partially due to the limited storage time, 6 weeks, in hypothermic storage. This time limit stems from high metabolism-driven storage lesions at +1-6 °C. A recent and promising alternative to hypothermic storage is the supercooled storage of RBCs at subzero temperatures, pioneered by our group. Here, we report on long-term supercooled storage of human RBCs at physiological hematocrit levels for up to 23 weeks. Specifically, we assess hypothermic RBC additive solutions for their ability to sustain supercooled storage. We find that a commercially formulated next-generation solution (Erythro-Sol 5) enables the best storage performance and can form the basis for further improvements to supercooled storage. Our analyses indicate that oxidative stress is a prominent time- and temperature-dependent injury during supercooled storage. Thus, we report on improved supercooled storage of RBCs at −5 °C by supplementing Erythro-Sol 5 with the exogenous antioxidants, resveratrol, serotonin, melatonin, and Trolox. Overall, this study shows the long-term preservation potential of supercooled storage of RBCs and establishes a foundation for further improvement toward clinical translation.

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Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Cited by 2 publications

References 33 publications

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Extended supercooled storage of red blood cells

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