Antiproliferative effect of synthetic cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against human cancer cell lines

Stiz, Dorimar Serafim; Campos, Adriana; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Corrêa, Rogério; Cechinel‐Filho, Valdir

doi:10.1515/znc-2016-0067

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…Thus, the unreacted thermal stabilizer remained in the polymer has in fact an effect on the antimicrobial activity of the polymer articles during their use. N-Substituted itaconimides are an attractive group of organic compounds possessing broad area of implementations in numerous domains in medicinal and pharmaceutical chemistry due to their significant abilities to be antibacterial, [21] antifungal [22] and antitumor [23] agents. Various 1,3,4-oxadiazoles possess a considerable activity for inhibition of growth of bacteria, [24] fungi.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of the thermal stability of PVC filled with multiwalled carbon nanotubes using new antimicrobic itaconimido aryl 1,3,4‐oxadiazoles

Mohamed

Al‐Harby

2020

Polymer Composites

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A series of PVC films stabilized with novel antimicrobial itaconimido aryl 1,3,4-oxadiazoles (D1'-D4'), at absence or presence of various concentrations of multiwalled carbon nanotubes (MWCNTs), was prepared by a conventional solution casting method. D1'-D4' was prepared via thermal cyclization processes by loss of water for their congruous predecessors itaconimido aryl hydrazides. Elemental analysis and various spectroscopy measurements were used to prove their structures. D1'-D4' have great antimicrobial activities and some of them showed similar or sometimes higher impact than the reference antibiotic. From TG measurements in nitrogen, they have high thermal stabilities and their decomposition temperatures were above 275-310 C in accordance with substituent groups NH 2 and/or OH incorporated into their structures. They have higher thermal stabilizing efficiencies for PVC in comparison with some industrial thermal stabilizers. Inclusion of 0.1-0.5 wt% MWCNTs into PVC films, that were stabilized with D4', enhanced the composites thermal stability. XRD, SEM as well as TEM were used for ascertaining of incorporation and well dispersion of MWCNTs into PVC matrices. Additionally, the efficacy of stabilization has been proven via a decreased rate of color alteration, mechanical properties change and chains cleavage for PVC. The high antimicrobial and thermal characteristics of these stabilizers afford them a great possibility to secure antimicrobial thermally stable PVC composites. Also, improvement of thermal and mechanical properties of PVC stabilized by D4' after its incorporation with MWCNTs afford a great possibility to its application in different fields where their thermal resistance and high tensile strength resistance play a very important role.

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