Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus <i>Stachybotrys</i> sp. KCB13F013

Kim, Jong Won; Ko, Sung‐Kyun; Kim, Hye-Min; Kim, Gun-Hee; Son, Sangkeun; Kim, Gil Soo; Hwang, Gwi Ja; Jeon, Eun Soo; Shin, Kee‐Sun; Ryoo, In‐Ja; Hong, Young-Shick; Oh, Hyuncheol; Lee, Kyung Ho; Soung, Nak-Kyun; Hashizume, Daisuke; Nogawa, Toshihiko; Takahashi, Shunji; Kim, Bo Yeon; Osada, Hiroyuki; Jang, Jae‐Hyuk; Ahn, Jong Seog

doi:10.1021/acs.jnatprod.6b00641

Cited by 29 publications

(17 citation statements)

References 31 publications

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“…KCB13F013 (Wi Island, South Korea, the Yellow Sea). Stachybotrysin exhibited an inhibitory effect on osteoclast differentiation in bone marrow macrophage cells via suppressing the RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1 [135].…”

Section: Discussionmentioning

confidence: 96%

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

2021

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Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their relationships are competitive. This results in wide variety of secondary metabolites produced by marine sediment-derived fungi both for environmental adaptation and for interspecies interactions. Earlier marine fungal metabolites were investigated mainly for their antibacterial and antifungal activities, but now also as anticancer and cytoprotective drug candidates. This review aims to describe low-molecular-weight secondary metabolites of marine sediment-derived fungi in the context of their biological activity and covers research articles published between January 2016 and November 2020.

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Section: Discussionmentioning

confidence: 96%

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

2021

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“…In 2016, Jong Won Kim et al reported the discovery of stachybotrysin ( 29 , Figure 11), which was isolated from the marine fungus Stachybotrys sp. KCB13F013 and found to inhibit the RANKL-induced activation of p-ERK, p-JNK and p-p38 MAPK [50]. The kinase inhibition activities of compound 28 and 29 were determined by Western blot analyses.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors

Wang

Zhang

et al. 2019

Marine Drugs

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Protein kinases are validated drug targets for a number of therapeutic areas, as kinase deregulation is known to play an essential role in many disease states. Many investigated protein kinase inhibitors are natural product small molecules or their derivatives. Many marine-derived natural products from various marine sources, such as bacteria and cyanobacteria, fungi, animals, algae, soft corals, sponges, etc. have been found to have potent kinase inhibitory activity, or desirable pharmacophores for further development. This review covers the new compounds reported from the beginning of 2014 through the middle of 2019 as having been isolated from marine organisms and having potential therapeutic applications due to kinase inhibitory and associated bioactivities. Moreover, some existing clinical drugs based on marine-derived natural product scaffolds are also discussed.

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“…terpenoid scalaradial (250) [275]; fungus Stachybotrys sp. KCB13F013 meroterpenoid stachybotrysin (251) [276]; soft coral Clavularia sp. terpenoid stolonidiol (252) [277]; cyanobacterium Lyngbya sp.…”

Section: Marine Compounds With Miscellaneous Mechanisms Of Actionmentioning

confidence: 99%

“…pyrroloiminoquinone alkaloid discorhabdin L (275) [297]; sponge Dysidea sp. polybrominated diphenyl ether 3,4,5-tribromo-2-(2 ,4 -dibromophenoxy)-phenol (276) [298]; sponge Dysidea sp. tetracyclic meroterpene dysiherbol A (277) [299]; sand dollar Scaphechinus mirabilis aminonaphtho-quinone echinamine B (278) [300]; sponge derived fungus Stachylidium sp.…”

Section: Marine Compounds With Miscellaneous Mechanisms Of Actionmentioning

confidence: 99%

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2021

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The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

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Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013

Cited by 29 publications

References 31 publications

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

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