A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors

Li, Te; Wang, Ning; Zhang, Ting; Zhang, Bin; Puthiyedathu, Sajeevan Thavarool; Joseph, V.; Armstrong, Lorene; He, Shan; Yan, Xiaojun; Naman, C. Benjamin

doi:10.3390/md17090493

Cited by 34 publications

(28 citation statements)

References 137 publications

(172 reference statements)

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“…31 Natural products from plants and animals exhibit high efficiency, low toxicity and other benefits. 32 It is widely reported that BA is cytotoxic to various types of human cancer cells. [28][29][30] In the present study, we assessed the antitumour effect of BA on human GC cells in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress

Chen

Liu

et al. 2020

Cell Biochemistry & Function

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Gastric cancer (GC) is one of the most prevalent types of malignancies. Betulinic acid (BA) is a natural pentacyclic triterpene with a lupine structure. However, to the best of our knowledge, there is no research study on the anti-tumour and anti-metastasis effect of BA on GC. In this study, we assessed the anti-cancer effect of BA on human GC cells in vitro and in vivo. We first investigated the cytotoxicity and antiproliferation effect of BA on GC cells of SNU-16 and NCI-N87. The results indicated that BA had significant cytotoxic and inhibitory effects on GC cells in a dose-and time-dependent manner. To further study the cytotoxic action of BA on GC cells, we assessed the apoptotic induction effect of BA on SNU-16 cells and found that BA distinctly induced apoptosis in SNU-16 cells. In addition, BA inhibited the migratory and invasive abilities of SNU-16 cells. Western-blot analysis revealed that BA suppressed the migration and invasion of GC cells by impairing epithelialmesenchymal transition progression. Furthermore, in vivo experiments showed that BA could delay tumour growth and inhibit pulmonary metastasis, which is consistent with the results of in vitro studies. Overall, we evaluated the anti-cancer effect of BA on human GC cells in vivo and in vitro, and the present study provides new evidence on the use of BA as a potential anti-cancer drug for GC treatment. Significance of the study: BA significantly suppressed proliferation and triggered apoptosis in GC cells. Additionally, BA remarkably inhibited migration and invasion of GC cells by impairing the epithelial-mesenchymal transition signalling pathway. It is worth noting that BA drastically retarded tumour growth in the xenograft mouse model of GC. Our results indicated that BA can be considered a candidate drug for GC therapy.

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Section: Discussionmentioning

confidence: 99%

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress

Chen

Liu

et al. 2020

Cell Biochemistry & Function

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“…However, most of these inhibitory molecules are natural products, and many are of marine origin. The latest findings in this field were recently reviewed and cover novel described compounds from 2014 onwards [17]. It seems as though marine habitats and their organisms bear a number of structural diverse molecules that act as kinase inhibitors.…”

Section: Enzyme Inhibitors From Marine Organismsmentioning

confidence: 99%

A Perspective on Enzyme Inhibitors from Marine Organisms

Tischler

2020

Marine Drugs

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Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments. This is, and will be, a promising source for candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques were introduced into the field, and it has become easier to actually prospect for natural products, such as enzyme inhibitors. These novel compounds then need to be characterized and evaluated in comparison to well-known representatives. A number of current research projects target the exploitation of marine organisms and thus the corresponding diversity of metabolites. These are often encountered as potential drugs or biological active compounds. Among these, the class of enzyme inhibitors is an important group of compounds. There is room for new discoveries, and some more recent discoveries are highlighted herein.

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“…Almost all sirtuin activators described to date target Sirt1. Furthermore, marine natural products have been shown to be an interesting source of kinase as well as proteasome inhibitors for cancer and neurodegenerative diseases [ 44 , 45 , 46 , 47 ]. Salinosporamide A, isolated from marine actinomycete Salinispora tropica , is one of the most potent proteasome inhibitors and is currently undergoing clinical trials for cancers [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process

Hassane¹,

Fouillaud²,

Goff

et al. 2020

Microorganisms

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Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the Proteobacteria phylum was the most abundant. In addition, 30 isolates from S. hapalia were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera Bacillus, Micromonospora, Rhodoccocus, Salinispora, Aspergillus, Chaetomium, Nigrospora and unidentified genera related to the family Thermoactinomycetaceae. Crude extracts from selected microbial cultures were found to be active against seven clinically relevant targets (elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome). These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive compounds.

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A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors

Cited by 34 publications

References 137 publications

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress

A Perspective on Enzyme Inhibitors from Marine Organisms

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process

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