Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

Yurchenko, Anton N.; Girich, Elena V.; Yurchenko, Ekaterina A.

doi:10.3390/md19020088

Cited by 23 publications

(17 citation statements)

References 141 publications

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“…A wide variety of chemical structures of steroids and terpenoids was found in extracts of marine sediments, as well as both contemporary and geologically ancient deposits [29,31,[109][110][111][112][113][114]. Aromatic sterols, triterpenoids, and sulfur-containing compounds have been found in marine sediments and crude oil [31][32][33][34][115][116][117][118][119][120].…”

Section: Sulfur-containing Steroids Derived From Marine and Terrestrial Sourcesmentioning

confidence: 99%

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

et al. 2021

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The review focuses on sulfated steroids that have been isolated from seaweeds, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing steroids and triterpenoids are sourced from sedentary marine coelenterates, plants, marine sediments, crude oil, and other geological deposits. The review presents the pharmacological profile of sulfated steroids, sulfur-containing steroids, and triterpenoids, which is based on data obtained using the PASS program. In addition, several semi-synthetic and synthetic epithio steroids, which represent a rare group of bioactive lipids that have not yet been found in nature, but possess a high level of antitumor activity, were included in this review for the comparative pharmacological characterization of this class of compounds. About 140 steroids and triterpenoids are presented in this review, which demonstrate a wide range of biological activities. Therefore, out of 71 sulfated steroids, thirteen show strong antitumor activity with a confidence level of more than 90%, out of 50 sulfur-containing steroids, only four show strong antitumor activity with a confidence level of more than 93%, and out of eighteen epithio steroids, thirteen steroids show strong antitumor activity with a confidence level of 91% to 97.4%.

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Section: Sulfur-containing Steroids Derived From Marine and Terrestrial Sourcesmentioning

confidence: 99%

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

et al. 2021

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“…The isolated compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) were evaluated for antimicrobial activity against several human-, aquatic-, and plant-pathogenic microbes (Table 4). Compound 4 showed activity against Fusarium graminearum Schw.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…The EtOAc extract was subjected to Silica gel VLC (vacuum liquid chromatography) and fractionated using solvent mixtures of increasing polarity consisting of petroleum ether (PE) and EtOAc (50:1 to 1:1), and subsequently with CH 2 Cl 2 -MeOH (50:1 to 1:1) to yield 11 fractions (Frs. [1][2][3][4][5][6][7][8][9][10][11]. Purification of fraction 6 (15.6 g), performed with CC (Column Chromatography) over Lobar LiChroprep RP-18 with a MeOH-H 2 O gradient (from 1:9 to 10:0), yielded 10 subfractions (fractions 6.1-6.10).…”

Section: Fermentation Extraction and Isolationmentioning

confidence: 99%

“…Deep-sea sediment has proven to be a treasure trove for structurally unique and biologically active secondary metabolites [1]. In the extreme environment of the deep-sea, microorganisms have gradually developed unique metabolic mechanisms out of adaption, thus possessing the great potential to produce natural products with significant biological properties, such as antimicrobial [2,3], cytotoxic [4], and antiviral [5] activities.…”

Section: Introductionmentioning

confidence: 99%

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Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406

Yan

Chi

et al. 2021

Marine Drugs

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Six new metabolites, including a pair of inseparable mixtures of secofumitremorgins A (1a) and B (1b), which differed in the configuration of the nitrogen atom, 29-hydroxyfumiquinazoline C (6), 10R-15-methylpseurotin A (7), 1,4,23-trihydroxy-hopane-22,30-diol (10), and sphingofungin I (11), together with six known compounds (2–5 and 8–9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus fumigatus SD-406. Their structures were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis of the acidic hydrolysate, X-ray crystallographic analysis, J-based configuration analysis, and quantum chemical calculations of ECD, OR, and NMR (with DP4+ probability analysis). Among the compounds, 1a/1b represent a pair of novel scaffolds derived from indole diketopiperazine by cleavage of the amide bond following aromatization to give a pyridine ring. Compounds 1, 4, 6, 7, 10 and 11 showed inhibitory activities against pathogenic bacteria and plant pathogenic fungus, with MIC values ranging from 4 to 64 μg/mL.

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“…Fumosorinone was isolated from the Isaria fumosorosea , and it is a potential medicine for the treatment of type II diabetes and other associated metabolic syndromes [ 20 ]. Diorcinol K, D, and I were isolated from Aspergillus , displaying significant antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus [ 21 ]. Pyrenocine A was produced by Paecilomyces and showed a significant antitrypanosomal activity against Trypanosoma brucei [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites of Purpureocillium lilacinum

Chen

2021

Molecules

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Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to Purpureocillium lilacinum. P. lilacinum are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and having a significant effect on Aphidoidea, Tetranychus cinnbarinus, and Aleyrodidae. At the same time, it produces secondary metabolites with various biological activities such as anticancer, antimicrobial, and insecticidal. This review attempts to provide a comprehensive overview of the secondary metabolites of P. lilacinum, with emphasis on the chemical diversity and biological activity of these secondary metabolites and the biosynthetic pathways, and gives new insight into the secondary metabolites of medical and entomogenous fungi, which is expected to provide a reference for the development of medicine and agrochemicals in the future.

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Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

Cited by 23 publications

References 141 publications

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406

Secondary Metabolites of Purpureocillium lilacinum

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