Identification of 10 transcripts of FREP in penaeid shrimp Litopenaeus vannamei

Hou, Fujun; Gao, Tengteng; Liu, Tao; Jia, Zhiying; Liu, Yongjie; Sun, Chengbo; Liu, Xiaolin

doi:10.1016/j.fsi.2016.09.032

Cited by 10 publications

(2 citation statements)

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“…Further, the FBG domain of P. japonicus could bind to PAMPs such as PGN, LPS and VP28 of WSSV, eliciting multidimensional PRR functions 212 . In P. vannamei , 10 transcripts of FREP were isolated with conserved FBG domains at the C‐terminus that were shown to agglutinate V. harveyi in the presence of Ca 2+ ions facilitating its clearance in vivo 213,214 . A FREP with lectin specificity has also been characterized from P. monodon binding to N‐acetyl sugars in a Ca 2+ ‐dependent manner with strong agglutination and weak binding properties against Pseudomonas aeruginosa and V. parahaemolyticus , respectively 215 .…”

Section: Prrs In Crustaceansmentioning

confidence: 99%

“…212 In P. vannamei, 10 transcripts of FREP were isolated with conserved FBG domains at the C-terminus that were shown to agglutinate V. harveyi in the presence of Ca 2+ ions facilitating its clearance in vivo. 213,214 A FREP with lectin specificity has also been characterized from P. monodon binding to N-acetyl sugars in a Ca 2+ -dependent manner with strong agglutination and weak binding properties against Pseudomonas aeruginosa and V. parahaemolyticus, respectively. 215 The antibacterial immunity of P. japonicus requires the participation of FREP2 as impairing its activity led to a reduction in the phagocytosis function of haemocytes.…”

Section: Fibrinogen-related Proteinsmentioning

confidence: 99%

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The role of pattern recognition receptors in crustacean innate immunity

Patnaik

Baliarsingh

Sarkar³

et al. 2023

Reviews in Aquaculture

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Crustacean species are among the most valued seafood with socioeconomic and ecological implications in the global fisheries sector. Microbial infections to the farming stock due to continued expansion and aquaculture puts global crustacean production at risk. Understanding and reviewing the complex innate immune system of crustaceans would be pivotal in formulating informed decisions for the control and management of epidemic diseases, thus making the global crustacean aquaculture industry sustainable. Under the purview of innate immunity in crustaceans, pattern recognition receptors (PRRs) represent the sensors capable of discriminating non‐self pathogenic modules and invoking the activation of immune responses. The immunity to infections can be manifested at cellular (via phagocytosis, apoptosis, nodulation and encapsulation) and humoral (effected by prophenoloxidase cascade, lectins, antimicrobial proteins) levels leading to the elimination of pathogens or subversion of the pathogenic implications. In this review, we discuss the participatory role of 12 types of PRRs identified from crustacean species with an exhaustive focus on structural and functional specificities in binding to pathogens and possible execution of the immune activity. Moreover, we have elaborated on the PRRs‐associated or possible signalling cascades (Toll‐NFκB, IMD‐NFκB and JAK‐STAT) in crustacean species that could bridge our understanding of the resistance or susceptibility of the host to varied pathogenic infections thus providing clues to the regulatory mechanisms involved in pathogenesis of infectious diseases and mechanisms of immunity.

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Section: Prrs In Crustaceansmentioning

confidence: 99%