Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment

Wang, Benlin; Li, Haoyuan; Yao, Qingyu; Zhang, Yulin; Zhu, Xiaodong; Xia, Tongliang; Wang, Jian; Li, Gang; Li, Xingang; Ni, Shilei

doi:10.1016/j.biopha.2016.08.033

Cited by 36 publications

(17 citation statements)

References 26 publications

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“…The characteristic adsorption peaks of PDLLA at 1750 cm −1 , which were attributed to a strong C=O peak in carboxylic acid and carbonyl moieties; the band at 1089 and 1180 cm −1 was assigned to C-O stretching vibration bands. The bands at 1451 and 1381 cm −1 corresponded to the C-H scissor bending vibrations [32,33]. Compared with the spectrum of PDLLA/nHA composite fibrous membranes, seen from Figure 5b,c, the specific adsorption peaks of PO4 3− at 1033, 603 and 564 cm −1 were found [32].…”

Section: Ftir Of Pdlla/nha Composite Fibrous Membranementioning

confidence: 93%

Electrospun Porous PDLLA Fiber Membrane Coated with nHA

Qiang

Zhang²,

Feng³

et al. 2018

Applied Sciences

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Featured Application: The PDLLA/nHA composite fibrous membrane has potential application value as scaffold material in tissue engineering.Abstract: Porous poly-D, L-lactic acid (PDLLA) electrospinning fiber membrane was prepared, and nano-hydroxyapatite (nHA) was adsorbed and wrapped into it during the unique shrinking process of the PDLLA fiber membrane to fabricate the PDLLA/nHA composite membrane scaffold for tissue engineering. Compare with the composite fibers prepared by blend electrospinning, most of nHA particles are observed to distribute on the surface of new type composite fibers, which could significantly improve the water wettability and induce the cellular adherence. FTIR analysis indicated that the PDLLA/nHA composite fibrous membrane was formed by physical adsorption. The combination was probed by scanning electron microscope, thermo-gravimetric, water contact angle and mechanical property analysis. It was proved that the nHA particles' content and distribution, surface wettability, modulus and tensile strength of PDLLA/nHA composite fibrous membrane were influenced by the concentration of nHA dispersion and pores on the PDLLA fiber surface. The 10.6 wt % PDLLA/nHA composite fibrous membrane exhibits a more balanced tensile strength (3.28 MPa) and surface wettability (with a water contact angle of 0 • ) of the composite mats. Scanning electron microscope and confocal laser scanning microscopy images of chondrocyte proliferation further showed that the composite scaffold is non-toxic. The adherence and proliferation of chondrocytes on the 10.6 wt % PDLLA/nHA fibrous membrane was significantly improved, compared with PDLLA mat. The 10.6 wt % PDLLA/nHA composite fibrous membrane has potential application value as scaffold material in tissue engineering.

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Section: Ftir Of Pdlla/nha Composite Fibrous Membranementioning

confidence: 93%

Electrospun Porous PDLLA Fiber Membrane Coated with nHA

Qiang

Zhang²,

Feng³

et al. 2018

Applied Sciences

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“…The drug in the ber membrane could be delivered in a targeted manner to the site of the tumor. 102 The surface modication of electrospun nano-bers with specic functional groups can achieve targeted capture of circulating tumor cells (CTCs), and the capture efficiency depends on the size and morphology of the nanobers.…”

Section: Drug Controlled Releasementioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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“…Due to their exceptional properties, it has been shown that electrospun nanofibers and their nanomats/nanowebs have potential use in various application areas in biotechnology, membranes/filters, food, agriculture, sensor, energy etc, (Aytac et al, 2015Noruzi, 2016;Sahay et al, 2012;Uyar and Kny, 2017). Electrospun nanofibers could also be used for drug delivery systems for targeted delivery and/or for inhibition of drug adverse side effects with controlled release (Aytac et al, 2015;Mendes et al, 2016;Wang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Polymer-free electrospun nanofibers from sulfobutyl ether 7 -beta-cyclodextrin (SBE 7 -β-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole

Yıldız

Çelebioğlu

Uyar

2017

International Journal of Pharmaceutics

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In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether-beta-cyclodextrin (SBE-β-CD, Captisol), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE-β-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE-β-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650±290nm for sulfisoxazole/SBE-β-CD-IC NF and 890±415nm for pure SBE-β-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE-β-CD in sulfisoxazole/SBE-β-CD-IC NF sample was confirmed by H NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE-β-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems.

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Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment

Cited by 36 publications

References 26 publications

Electrospun Porous PDLLA Fiber Membrane Coated with nHA

Electrospun Porous PDLLA Fiber Membrane Coated with nHA

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Polymer-free electrospun nanofibers from sulfobutyl ether 7 -beta-cyclodextrin (SBE 7 -β-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole

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