Electrospun Porous PDLLA Fiber Membrane Coated with nHA

Abstract

Featured Application: The PDLLA/nHA composite fibrous membrane has potential application value as scaffold material in tissue engineering.Abstract: Porous poly-D, L-lactic acid (PDLLA) electrospinning fiber membrane was prepared, and nano-hydroxyapatite (nHA) was adsorbed and wrapped into it during the unique shrinking process of the PDLLA fiber membrane to fabricate the PDLLA/nHA composite membrane scaffold for tissue engineering. Compare with the composite fibers prepared by blend electrospinning, most of nHA particles are observed to distribute on the surface of new type composite fibers, which could significantly improve the water wettability and induce the cellular adherence. FTIR analysis indicated that the PDLLA/nHA composite fibrous membrane was formed by physical adsorption. The combination was probed by scanning electron microscope, thermo-gravimetric, water contact angle and mechanical property analysis. It was proved that the nHA particles' content and distribution, surface wettability, modulus and tensile strength of PDLLA/nHA composite fibrous membrane were influenced by the concentration of nHA dispersion and pores on the PDLLA fiber surface. The 10.6 wt % PDLLA/nHA composite fibrous membrane exhibits a more balanced tensile strength (3.28 MPa) and surface wettability (with a water contact angle of 0 • ) of the composite mats. Scanning electron microscope and confocal laser scanning microscopy images of chondrocyte proliferation further showed that the composite scaffold is non-toxic. The adherence and proliferation of chondrocytes on the 10.6 wt % PDLLA/nHA fibrous membrane was significantly improved, compared with PDLLA mat. The 10.6 wt % PDLLA/nHA composite fibrous membrane has potential application value as scaffold material in tissue engineering.

Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration

“…The water contact angle (WCA) was highest for untreated PDLLA (123.1° ± 2.1°), followed by PDLLA/PLGA, and the lowest contact angle (106.9° ± 2.4°) was measured for untreated PLGA (see Figure 9), which is in agreement with literature reports [67,68,69]. Surface modification with electrosprayed nHA caused only a slightly lower contact angle values in comparison with untreated samples.…”

Biomimetic, mussel-inspired surface modification of 3D-printed biodegradable polylactic acid scaffolds with nano-hydroxyapatite for bone tissue engineering

“…However, the presence of residual organic solvents (e.g., chloroform and dichloromethane) resulted in harmful effects on cells and tissues ( Chakraborty et al, 2018 ; Gayer et al, 2019 ). More importantly, the surface of scaffolds was not ideally functionalized since most of the nHA particles are entrapped in the PLA matrix, resulting in limited hydrophilicity, cell recruitment, and osteo-stimulating effects ( Qiang et al, 2018 ; Liu et al, 2020 ).…”