Erratum to: The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach

Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies

“…After 48 weeks of treatment with EGCG or a placebo, it was demonstrated that this compound has an effect on disease progression in patients with MSA. These findings concluded that EGCG is capable of modifying the structure of toxic α-syn in the oligomeric state, interfering with the core of many protein disease mechanisms. , …”

“…These findings concluded that EGCG is capable of modifying the structure of toxic α-syn in the oligomeric state, interfering with the core of many protein disease mechanisms. 129,130 During a pilot study, 15 patients between 50 and 80 years old were assigned to drink three cups of green tea daily for 3 months. To assess PD-related disability, a series of rating tools were used to gauge the course of PD in patients (UPDRS, H & Y, S & E, PDQ-39).…”

The Potential Toxic Side Effects of Flavonoids

“…A randomized, double-blind clinical trial in Germany demonstrated that two patients in the group treated with epigallocatechin gallate had to remove from the experiment because of hepatotoxicity. The doses of more than 1200 mg intake daily may be used with caution (Levin et al, 2019). EGCG was overall well tolerated in the other 45 patients, these inconsistent results revealed that genetic and/or lifestyle factors may play an important role in susceptibility to EGCG-mediated hepatotoxicity.…”

“…Though many data have also confirmed that flavonoids have exhibited significant liver-protection and renal-protection properties in vitro and in vivo (Kandemir et al, 2020;Levin et al, 2019;Levin et al, 2016;Papackova et al, 2018), few studies also showed the potential hepatotoxicity and nephrotoxicity with epigallocatechin gallate (EGCG) intake (James et al, 2015;Lambert et al, 2010;Levin et al, 2019;Levin et al, 2016). The underlying mechanism of flavonoids is not clear but could be proposed that the transitory intake results in oxidative stress leading to liver and kidney injury under high-dose conditions.…”

Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration

“…For example, some preclinical studies have shown that a 200 mg/kg/day of ethylacetate extract of grape fruits, enriched in various catechins including EGCG, can reduce toxic A1-42 protein deposition in the brain and improve cognitive functions in an animal model of AD [161]. Additionally, 100-300 mg/kg/day of EGCG prior to rotenone daily injections prevented the development of Parkinsonism-like symptoms in rats, through a reduction of neuroinflammation and lipid peroxidation and the stimulation of metabolic activity in the brain, along with increased catecholamine concentrations in the corpus striatum [162]. These studies and others, reviewed in [91], clearly highlight the need for high daily EGCG doses to achieve any significant therapeutic effect, based on the chemical instability of EGCG, its extensive metabolism and its low bioavailability.…”