An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry

Zhang, Yiding; Ai, Wanpeng; Bai, Yu; Zhou, Ying‐Lin; Zhang, Xin‐Xiang; Liu, Huwei

doi:10.1007/s00216-016-9822-3

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…The LOD ( S / N = 3) for analysis of l -alanine was calculated to be 0.84 pmol, which is lower than the LOD obtained from volume DBDI (3.5 pmol) . Also, the LOD for metronidazole was determined to be 0.18 pmol (also expressed as 0.09 μmol/L), which is lower than the LOD (0.15 mmol/L) for DBDI . These results demonstrate that SDDBDI-MS with the advantage of high-efficiency ion transmission is a very sensitive method.…”

Section: Resultsmentioning

confidence: 63%

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Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry

Zou

Jiang

et al. 2017

Anal. Chem.

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A variant of dielectric-barrier discharge named surface desorption dielectric-barrier discharge ionization (SDDBDI) mass spectrometry was developed for high-efficiency ion transmission and high spatial resolution imaging. In SDDBDI, a tungsten nanotip and the inlet of the mass spectrometer are used as electrodes, and a piece of coverslip is used as a sample plate as well as an insulating dielectric barrier, which simplifies the configuration of instrument and thus the operation. Different from volume dielectric-barrier discharge (VDBD), the microdischarges are generated on the surface at SDDBDI, and therefore the plasma density is extremely high. Analyte ions are guided directly into the MS inlet without any deflection. This configuration significantly improves the ion transmission efficiency and thus the sensitivity. The dependence of sensitivity and spatial resolution of the SDDBDI on the operation parameters were systematically investigated. The application of SDDBDI was successfully demonstrated by analysis of multiple species including amino acids, pharmaceuticals, putative cancer biomarkers, and mixtures of both fatty acids and hormones. Limits of detection (S/N = 3) were determined to be 0.84 and 0.18 pmol, respectively, for the analysis of l-alanine and metronidazole. A spatial resolution of 22 μm was obtained for the analysis of an imprinted cyclophosphamide pattern, and imaging of a "T" character was successfully demonstrated under ambient conditions. These results indicate that SDDBDI has high-efficiency ion transmission, high sensitivity, and high spatial resolution, which render it a potential tool for mass spectrometry imaging.

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Section: Resultsmentioning

confidence: 63%

“…19 Also, the LOD for metronidazole was determined to be 0.18 pmol (also expressed as 0.09 μmol/L), which is lower than the LOD (0.15 mmol/L) for DBDI. 27 These results demonstrate that SDDBDI-MS with the advantage of highefficiency ion transmission is a very sensitive method.…”

Section: ■ Results and Discussionmentioning

confidence: 78%

Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry

Zou

Jiang

et al. 2017

Anal. Chem.

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“…Zhang et al. developed a CE‐MS interface based on dielectric barrier discharge ionization, separating a mixture of metronidazole and acetaminophen solutions in a proof‐of‐concept study .…”

Section: Instrumentation Interfacing Methodologymentioning

confidence: 99%

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

et al. 2018

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Capillary electrophoresis (CE) offers fast and high‐resolution separation of charged analytes from small injection volumes. Coupled to mass spectrometry (MS), it represents a powerful analytical technique providing (exact) mass information and enables molecular characterization based on fragmentation. Although hyphenation of CE and MS is not straightforward, much emphasis has been placed on enabling efficient ionization and user‐friendly coupling. Though several interfaces are now commercially available, research on more efficient and robust interfacing with nano‐electrospray ionization (ESI), matrix‐assisted laser desorption/ionization (MALDI) and inductively coupled plasma mass spectrometry (ICP) continues with considerable results. At the same time, CE‐MS has been used in many fields, predominantly for the analysis of proteins, peptides and metabolites. This review belongs to a series of regularly published articles, summarizing 248 articles covering the time between June 2016 and May 2018. Latest developments on hyphenation of CE with MS as well as instrumental developments such as two‐dimensional separation systems with MS detection are mentioned. Furthermore, applications of various CE‐modes including capillary zone electrophoresis (CZE), nonaqueous capillary electrophoresis (NACE), capillary gel electrophoresis (CGE) and capillary isoelectric focusing (CIEF) coupled to MS in biological, pharmaceutical and environmental research are summarized.

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“…By a similar set up, CE was also coupled to DBDI-MS recently. 52 A sheathless coupling of CE with MS was realized by an ambient ion source, miniFAPA. 53 The outlet of the CE capillary coated with silver paint was inserted into a T-junction, inside which a nebulizer gas was used to vaporize the effluent of CE.…”

Section: Capillary Electrophoresismentioning

confidence: 99%

Online coupling techniques in ambient mass spectrometry

Zhang

et al. 2016

Analyst

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Since ambient mass spectrometry (AMS) has been proven to have low matrix effects and high salt tolerance, great efforts have been made for online coupling of several analytical techniques with AMS. These analytical techniques include gas chromatography (GC), liquid chromatography (LC), capillary electrophoresis (CE), surface plasmon resonance (SPR), and electrochemistry flow cells. Various ambient ionization sources, represented by desorption electrospray ionization (DESI) and direct analysis in real time (DART), have been utilized as interfaces for the online coupling techniques. Herein, we summarized the advances in these online coupling methods. Close attention has been paid to different interface setups for coupling, as well as limits of detection, tolerance to different matrices, and applications of these new coupling techniques.

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An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry

Cited by 16 publications

References 19 publications

Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry

Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

Online coupling techniques in ambient mass spectrometry

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