Validation of an Argentine version of Lupus Quality of Life questionnaire

Escobar, Mariana; Yacuzzi, Maria S; Martínez, Rachael N.; Lucero, Luciana González; Bellomio, Verónica; Santana, Mirta; Galindo, L. M.; Mayer, Miroslav; Barreira, Juan Carlos; Sarano, Judith; Gómez, Graciela; Collado, María Victoria; Martínez, Agustín; Orozco, María Celeste; Betancur, G; Pra, Fernando Dal; Sánchez, Angel; Juárez, Vicente; Lucero, Eleonora

doi:10.1177/0961203316660202

Cited by 13 publications

(7 citation statements)

References 25 publications

(50 reference statements)

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“…Furthermore, a cohort study of 182 French patients with SLE showed that the French version of LupusQoL was significantly lower only for physical health, pain, and intimate relationship in patients with SLEDAI >4 [ 30 ]. Conversely, no significant differences in any domains of an Argentine version of LupusQoL were observed between 147 patients with a SLEDAI score of <4 and ≥4 [ 31 ]. The heterogeneity of the findings from the abovementioned studies might be explained by differences in ethnic composition, cultural setting, and healthcare infrastructure, which could affect the perception of HRQoL in patients with SLE [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life

Lai

Chang

et al. 2021

JCM

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Background and Aim: The aim of this study was to compare the correlation of a recently developed systemic lupus erythematosus disease activity score (SLE-DAS) with the SLE disease activity index 2000 (SLEDAI-2K) with the Lupus Quality of Life questionnaire (LupusQoL) in Taiwanese patients with SLE. Methods: A cross-sectional study was conducted in a regional teaching hospital in Taiwan from April to August 2019. Adult patients with a clinician-confirmed diagnosis of SLE based on the 1997 American College of Rheumatology revised criteria or the 2012 Systemic Lupus International Collaborating Clinics Classification Criteria were recruited. SLE disease activity was measured with both SLEDAI-2K and SLE-DAS. Disease-specific quality of life was assessed using the LupusQoL. Results: Of the 333 patients with SLE in this study, 90.4% were female and 40% were between the ages of 20 and 39 years. The median SLEDAI-2K score was 4.00 (interquartile range [IQR] 2.00–7.50) and the median SLE-DAS score was 2.08 (IQR 1.12–8.24) in our patients with SLE. After adjusting for sex and age intervals, both SLEDAI-2k and SLE-DAS were significantly and inversely associated with all eight domains of LupusQoL. The magnitudes of the mean absolute error, root mean square error, Akaike Information Criterion, Bayesian Information Criterion, and coefficient of determination were comparable between SLEDAI-2K and SLE-DAS. Conclusions: There were no clear differences in the use of SLE-DAS over SLEDAI-2K in assessing HRQoL in patients with SLE. We suggest that, in this aspect, both SLEDAI-2K and SLE-DAS are effective tools for measuring disease activity in patients with SLE.

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Section: Discussionmentioning

confidence: 99%

A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life

Lai

Chang

et al. 2021

JCM

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“…Comparatively, in Argentina, LupusQoL was associated neither with disease activity nor with damage. 18…”

Section: Introductionmentioning

confidence: 99%

“…Comparatively, in Argentina, LupusQoL was associated neither with disease activity nor with damage. 18 Research regarding the factors associated with HRQoL in Latin American patients with SLE remains limited. In order to address this knowledge gap toward the goal of improving management and care, we conducted this study in order to define factors associated with HRQoL in predominantly Mestizo patients with SLE using a disease-specific tool for HRQoL (LupusQoL).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with health-related quality of life in Peruvian patients with systemic lupus erythematosus

Elera-Fitzcarrald

Alva

Gamboa-Cárdenas

et al. 2018

Lupus

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Objective In this paper, we aim to define factors associated with health-related quality of life (HRQoL) in Mestizo patients with systemic lupus erythematosus (SLE). Methods We evaluated patients with SLE from Peru's two largest hospitals between October 2012 and July 2015 to ascertain HRQoL. Using a standard protocol, we incorporated demographic characteristics, clinical manifestations and treatment in our analysis. HRQoL was measured with the LupusQoL, disease activity was ascertained with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and damage was appraised with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). The associations between the LupusQoL and these variables were examined using linear regression models. Model selection was based on backward elimination. Results A total of 277 patients fit the inclusion criterion. Of these, 254 (91.7%) were female, the median (interquartile range, IQR) age at diagnosis was 41.5 (33.8-51.8) years, disease duration was 6.5 (2.7-11.3) years. The HRQoL domains most affected were the following: burden to others, fatigue, and intimate relationships. Through multivariate analysis, we determined that older age at diagnosis, higher disease activity, damage, and immunosuppressive drug use were negatively associated with HRQoL. Further, we found that higher socioeconomic status, disease duration, and antimalarial use were positively associated with HRQoL. Conclusion Age at diagnosis, disease activity, damage, and use of immunosuppressive drugs were negatively associated with HRQoL; high socioeconomic status, disease duration, and use of antimalarials were positively associated with HRQoL.

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“…It has been adapted and validated in different languages including Spanish. 21 It contains 34 items grouped into eight domains: physical health, pain, planning, intimate relationships, burden to others, emotional health, body image, and fatigue. The total score ranges from 0 (worst QoL) to 100 (best QoL).…”

Section: Slaqmentioning

confidence: 99%

Validation and adaptation of the Spanish version of the systemic lupus activity questionnaire (S-SLAQ) in an Argentinean population

Catoggio

Muñoz

Moral

et al. 2021

Lupus

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Objectives To validate the systemic lupus activity questionnaire (SLAQ) in Spanish language. Methods The SLAQ questionnaire was translated and adapted in Spanish. Consecutive SLE patients from 8 centers in Argentina were included. A rheumatologist completed a Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2K, and a physician’s assessment. Reliability was assessed by internal consistency (Cronbach’s alpha), stability by test–retest reliability (intraclass correlation coefficient), and construct validity by evaluating the correlation with clinically relevant scores. Sensitivity and specificity for clinically significant disease activity (SLEDAI ≥6) of different S-SLAQ cut-off points were evaluated. Results We included 97 patients ((93% female, mean age: 40 years (SD14.7)). Internal consistency was excellent (Cronbach’s alpha = 0.84, p < 0.001), and the intraclass correlation coefficient was 0.95 ( p < 0.001). Mean score of S-SLAQ was 8.2 (SD 7.31). Correlation of S-SLAQ was moderate with Patient NRS (r= 0.63 p< 0.001), weak with SLAM-no lab ( r = 0.42, p <0.001) and SLAM ( r = 0.38, p < 0.0001), and very weak with SLEDAI-2K ( r = 0.15, p =0.1394). Using the S-SLAQ cutoff of five points, the sensitivity was 72.2% and specificity was 37.9%, for clinically significant disease activity. Conclusions The S-SLAQ showed good validity and reliability. A good correlation, similar to the original instrument, was observed with patient´s global disease activity. No correlation was found between S-SLAQ and gold standard disease activity measures like SLEDAI-2K and SLAM. The S-SLAQ cutoff point of 5 showed a good sensitivity to identify the active SLE population and therefore could be an appropriate screening instrument for disease activity in clinical and epidemiological studies.

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Validation of an Argentine version of Lupus Quality of Life questionnaire

Abstract: The Argentine version of LupusQoL is a valid, reliable and reproducible instrument to assess quality of life. In this study, cut-off points that allow the classification of patients regarding whether they have good or bad quality of life are established for the first time.

Cited by 13 publications

References 25 publications

A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life

A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life

Factors associated with health-related quality of life in Peruvian patients with systemic lupus erythematosus

Validation and adaptation of the Spanish version of the systemic lupus activity questionnaire (S-SLAQ) in an Argentinean population

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