Factors associated with health-related quality of life in Peruvian patients with systemic lupus erythematosus

Abstract

Objective In this paper, we aim to define factors associated with health-related quality of life (HRQoL) in Mestizo patients with systemic lupus erythematosus (SLE). Methods We evaluated patients with SLE from Peru's two largest hospitals between October 2012 and July 2015 to ascertain HRQoL. Using a standard protocol, we incorporated demographic characteristics, clinical manifestations and treatment in our analysis. HRQoL was measured with the LupusQoL, disease activity was ascertained with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and damage was appraised with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). The associations between the LupusQoL and these variables were examined using linear regression models. Model selection was based on backward elimination. Results A total of 277 patients fit the inclusion criterion. Of these, 254 (91.7%) were female, the median (interquartile range, IQR) age at diagnosis was 41.5 (33.8-51.8) years, disease duration was 6.5 (2.7-11.3) years. The HRQoL domains most affected were the following: burden to others, fatigue, and intimate relationships. Through multivariate analysis, we determined that older age at diagnosis, higher disease activity, damage, and immunosuppressive drug use were negatively associated with HRQoL. Further, we found that higher socioeconomic status, disease duration, and antimalarial use were positively associated with HRQoL. Conclusion Age at diagnosis, disease activity, damage, and use of immunosuppressive drugs were negatively associated with HRQoL; high socioeconomic status, disease duration, and use of antimalarials were positively associated with HRQoL.

The relations of quality of life in patients with lupus erythematosus: Regression models versus qualitative comparative analysis

“…Based on the obtained results, hypothesis one can be partially accepted. A younger age is related to higher levels of QL, as suggested by previous studies (Elera‐Fitzcarrald et al., ). About the influence of sex on the QL (H1), there does not seem to be any empirical evidence to support such a hypothesis.…”

“…Based on the existing literature, it was hypothesized that women (Jolly et al., ; Vasquez et al., ) and older people (Elera‐Fitzcarrald et al., ) have a lower QL (H1) that a longer time to diagnosis or a longer time with lupus have a negative effect on the QL (H2) (Batalla et al., ) and that SLE patients have a lower QL compared with CLE patients (H3) (Reis et al., ).…”

“…Despite these differences, the influence of sex continues to be an aspect of interest, as other studies suggest not to be differences amongst men and women (Jolly et al., ). Another relevant aspect is the age of the patient and some studies have observed a lower QL in young people (Glinac, Matovic, Saric, & Bratovcic, ; Vasquez et al., ), while other studies suggest that the older the patient is, the greater is the number of associated complications they will have, which has a negative impact on the QL (Elera‐Fitzcarrald, Alva, Gamboa‐Cardenas, & Mora‐Trujillo, ). Although the QL of patients with chronic diseases may be influenced by sex or age, studies in patients with lupus are scarce and inconclusive (Elera‐Fitzcarrald et al., ; Jolly et al., ).…”

“…Another relevant aspect is the age of the patient and some studies have observed a lower QL in young people (Glinac, Matovic, Saric, & Bratovcic, ; Vasquez et al., ), while other studies suggest that the older the patient is, the greater is the number of associated complications they will have, which has a negative impact on the QL (Elera‐Fitzcarrald, Alva, Gamboa‐Cardenas, & Mora‐Trujillo, ). Although the QL of patients with chronic diseases may be influenced by sex or age, studies in patients with lupus are scarce and inconclusive (Elera‐Fitzcarrald et al., ; Jolly et al., ). Due to the contradiction between authors and the fact that the socio‐demographic variables most studied by the different disciplines—both psychology and nursing—have been sex and age, it is recommended to study their influence on QL in greater depth.…”

Factors Influencing Health-Related Quality of Life in Patients With Systemic Lupus Erythematosus

“…Так, у молодых пациенток с поражением кожи отмечалось самое низкое КЖСЗ, которое сочеталось с депрессией. В то же время другие авторы сообщают, что у пациентов с СКВ старше 40 лет КЖСЗ по всем шкалам было значительно ниже, чем в более молодом возрасте [16,17].…”